Filetype
BACKGROUND: Chemotherapy drug distribution varies greatly among individual patients. Therefore, we developed an individualised fluorouracil, epirubicin, cyclophosphamide (FEC) regimen to improve outcomes in patients with high-risk early breast cancer. We then did a randomised trial to compare this individually tailored FEC regimen with conventional adjuvant chemotherapy followed by consolidation w
Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 partic
Background: The COVID-19 outbreak has resulted in collision between patients infected with SARS-CoV-2 and those with cancer on different fronts. Patients with cancer have been impacted by deferral, modification, and even cessation of therapy. Adaptive measures to minimize hospital exposure, following the precautionary principle, have been proposed for cancer care during COVID-19 era. We present he
Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines ar
The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated T cells. Antibodies targeting 4-1BB enhance the proliferation and survival of antigen-stimulated T cells in vitro and promote CD8 T cell-dependent anti-tumor immunity in pre-clinical cancer models. We found that T regulatory (Treg) cells infiltrating human or murine tumors expressed high amounts of 4-1BB.
Making it big with nano-crafting Hoppa till huvudinnehåll Vi använder cookies och andra spårningsteknologier för att förbättra användarupplevelsen på vår webbplats, för att visa dig personligt innehåll och riktade annonser och för att analysera vår webbplatstrafik. Läs mer om cookies. Absolut nödvändiga cookies Dessa cookies är nödvändiga för att webbplatsen ska fungera och kan inte stängas av i v
https://www.lth.se/article/making-it-big-with-nano-crafting/ - 2026-07-21
Gene panel sequencing has become a common diagnostic tool for detecting somatically acquired mutations in myeloid neoplasms. However, many panels have restricted content, provide insufficient sensitivity levels, or lack clinically validated workflows. We here describe the development and validation of the Genomic Medicine Sweden myeloid gene panel (GMS-MGP), a capture-based 191 gene panel includin
TP53 is the most frequently mutated gene in human cancer. This gene shows not only loss-of-function mutations but also recurrent missense mutations with gain-of-function activity. We have studied the primary bone malignancy osteosarcoma, which harbours one of the most rearranged genomes of all cancers. This is odd since it primarily affects children and adolescents who have not lived the long life
Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association study on blood IgG subclass levels. Across 4334 adults and 4571 individuals under 18 years, we discover ten new and identify four known variants at five loci
Background: Platelet transfusions are given to preterm infants with severe thrombocytopenia aiming to prevent haemorrhage. The PlaNeT2/MATISSE trial revealed higher rates of mortality and/or major bleeding in preterm infants receiving prophylactic platelet transfusions at a platelet count threshold of 50 × 109/L compared to 25 × 109/L. The extent to which this evidence has been incorporated into c
BACKGROUND: Skin cancer is a prevalent and clinically significant condition, with early and accurate diagnosis being crucial for improved patient outcomes. Dermoscopy and artificial intelligence (AI) hold promise in enhancing diagnostic accuracy. However, the impact of image quality, particularly high dynamic range (HDR) conversion in smartphone images, on diagnostic performance remains poorly und
Pseudouridine synthases (PUSs) catalyze the isomerization of uridine (U)-to-pseudouridine (Ψ) and have emerging roles in development and disease. How PUSs adapt gene expression under stress remains mostly unexplored. We identify an unconventional role for the Ψ "writer" PUS10 impacting intracellular innate immunity. Using Pus10 knockout mice, we uncover cell-intrinsic upregulation of interferon (I
Praktik Holst Wahlgren (004)_edited LTH:s 9:e Pedagogiska Inspirationskonferens, 15 december 2016 Abstract— I detta arbeta vill vi rikta fokus på den yrkesinriktade ingenjörsträningen som infördes för att antal år sedan. Här arbetar studenten på ett företag eller inom någon annan verksamhet under 2 månader. Varje vecka skrivs en reflektion över dragna erfarenheter. Utöver detta gör studenten en sa
https://www.lth.se/fileadmin/lth/genombrottet/konferens2016/32_Holst_Wahlgren.pdf - 2026-06-09
OKTOBER Hejsan kära läsare! Tänk, nu kommer oktobers nummer av månadsbrevet från Modevetenskapliga Studierådet det är ju helt otroligt vad fort det går. Denna månaden har det varit fullt upp med förberedelser inför det modevetenskapliga programmets 10-årsjubileum som nyss gått av stapeln vilket var något alldeles otroligt att få fira. En punkt i utställningen som hörde jubiléet till var att besöka
https://www.kultur.lu.se/fileadmin/user_upload/kultur/Utbildning/Mode_maanadsbrev/Maanadsbrev_Oktober_2022.pdf - 2026-07-20
Språklig profil SPRÅKLIG PROFIL Råd och riktlinjer för hur du ska uttrycka dig i text Språklig profil för Saco-S En språklig profil visar hur du ska uttrycka dig i text. Råden och riktlinjerna gäller alla våra texter, men fokus ligger på texter för vår webbplats. Den språkliga profilen förklarar och visar exempel på ⎯ vilken relation vi vill ha till våra förtroendevalda, medlemmar och övriga målgr
https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/saco-s/mallar-mm/spraklig-profil-for-saco-s.pdf - 2026-07-20
RICHARD BARK Strindberg i Lund En promenad genom staden i författarens fotspår Det finns 90 städer i Sverige, och till den som jag avskyr mest ha makterna dömt mig. Så skriver Strindberg i sin självbiografiska roman Inferno (1897) och han fortsätter: Varför och huru har jag drivits att slå mig ned i denna lilla universitetsstad, beryktad såsom en relegations- eller botgöringsort för Uppsalastudent
https://www.css.lu.se/fileadmin/user_upload/project/css/Rethinking_Scandinavia_-_Resurser/ii.pdf - 2026-07-20
Trump gör presidentvalet till en wrestlingmatch Trump gör presidentvalet till en wrestlingmatch Av Ellen Albertsdóttir - Publicerad den 12 september 2024 Donald Trump har en stark koppling till professionell wrestling, framför allt genom sitt samarbete med World Wrestling Entertainment (WWE). Foto: Hugo Fernandes, CC BY-SA 2.0, via Wikimedia Commons Donald Trumps bakgrund inom amerikansk wrestling
https://www.ctr.lu.se/article/trump-goer-presidentvalet-till-en-wrestlingmatch/ - 2026-07-20
