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Identification of novel biomarkers for early diagnosis, prognosis, and treatment decision will be instrumental for improving disease outcome for patients suffering from complex diseases, such as cancer and autoimmune disorders. Within personalized medicine, the use of circulating biomarkers will allow clinicians to tailor medical treatment based on individual characteristics of each patient, using

Food security can be defined as stable access to food of good nutritional quality. In Sub Saharan Africa access to food is strongly linked to local food production and the capacity to generate enough calories to sustain the local population. Therefore it is important in these regions to generate not only sufficiently high yields but also to reduce interannual variability in food production. Tradit

If water stays on wood surfaces or is trapped in gaps, the wood is supplied with water for a long period of time and high local moisture contents are reached. This can lead to decay by rot fungi, and it is therefore important to avoid such water traps in order to limit the decay rate. This paper presents two methods: one for determination of duration of surface moisture on wood surfaces and one fo

The rate coefficients for the chemical reactions (species loss rates, quenching excluded) of the refrigerants CH2F2 (HFC-32), CHClF2 (HFC-22) and CH2FCF3 (HFC-134a), and the solvent CH3CCl3 with O(D-1) are determined relative to CH4 + O(D-1) at 298 K. The resulting rates k(CH2F2 + O(D-1)) = (4.78 +/- 1.03) x 10 (11) cm(3) molecule (1) s (1), k(CHClF2 + O(D-1)) = (8.69 +/- 1.72) x 10 (11) cm(3) mol

Eae5 in rats was originally identified in two F-2 intercrosses, (DA x BN) and (E3 X DA), displaying linkage to CNS inflammation and disease severity in experimental autoimmune encephalomyelitis (EAE), respectively. This region overlaps with an arthritis locus, Pia4, which was also identified in the (E3 X DA) cross. Two congenic strains, BN.DA-Eae5 and BN.DA-Eae5.R1, encompassing the previously des

The complete mitochondrial genomes of two reptiles, the common iguana (Iguana iguana) and the caiman (Caiman crocodylus), were sequenced in order to investigate phylogenetic questions of tetrapod evolution. The addition of the two species allows analysis of reptilian relationships using data sets other than those including only fast-evolving species. The crocodilian mitochondrial genomes seem to h

Pressurized liquid extractions were performed on eight sediments in order to investigate if a modified US EPA method (100 degrees C, 100 bar, n-heptane/acetone (1:1), 2 x 5 min) provided exhaustive extractions of polychlorinated biphenyls (PCBs) from sediment, and to study if the extractability of PCBs from the different sediments was affected by characteristics of the sediment. The recovery from

Cocaine- and amphetamine-regulated transcript-derived peptides (CARTp) and corticotropin-releasing factor (CRF) alter feeding and gastrointestinal function after central administration, and the gastric inhibitory effects are mediated through CRF. We hypothesized that dorsal hindbrain effects of CARTp on gastric emptying are mediated by the vagus nerve and that the dorsal vagal complex (DVC) is a s

Coupled cluster methods are compared to multiconfigurational second-order perturbation theory in a study of the high spin d(x)s(2) -> d(x+1)s(1) excitations in first, second, and third row transition metals. Large basis sets of the atomic natural orbital type are used. Scalar relativistic effects are included using the Douglas-Kroll-Hess Hamiltonian. The effect of spin-orbit coupling is demonstrat

Neutral B meson oscillations in the B-s(0) - <(B-s(0))over bar>, and B-d(0) - <(B-d(0))over bar> systems were studied using a sample of about 4.0 million hadronic Z decays recorded by the DELPHI detector between 1992 and 2000. Events with a high transverse momentum lepton were removed and a sample of 770 k events with an inclusively reconstructed vertex was selected. The mass difference between th

Biotinylated negatively charged liposomes as well as membranes were affinity partitioned in an aqueous poly(ethylene glycol)-dextran two-phase system using NeutrAvidin conjugated to dextran as affinity ligand. Both liposomes and membranes redistributed from top to bottom phase upon addition of NeutrAvidin-dextran. The presence of 35-60 mM Li2SO4 was necessary both to force the components into the

A decade has passed since the first human embryonic stem cell (hESC) line was established, providing immense hope in curing diseases by cell replacement therapy. For instance, in the pancreas, the insulin-producing β-cells are damaged in diabetes patients, and a successful replacement of those cells could provide a cure. These cells can be replaced by organ donation, but owing to a profound scarci

OBJECTIVE: To estimate the accuracy of endometrial thickness measurement in the detection of endometrial cancer among women with postmenopausal bleeding with individual patient data using different meta-analytic strategies. DATA SOURCES: Original data sets of studies detected after reviewing the included studies of three previous reviews on this subject. An additional literature search of publishe

Recent contributions to ecological economics and related social sciences indicate that issues such as climate change, resource depletion and environmental degradation cannot be effectively addressed under conditions of continued economic growth. This paper aims at empirically identifying structural potentials and policy challenges for prosperity at scaleswhere economic development remainswithin ec

Purpose – This paper aims to develop a novel micro-ablation system to realise micrometric and well-defined hydrogel structures. To engineer a tissue it is necessary to evaluate several aspects, such as cell-cell and cell-substrate interactions, its micro-architecture and mechanical stimuli that act on it. For this reason, it is important to fabricate a substrate which presents a microtopology simi