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Study Type - Diagnosis (cohort) Level of Evidence 2a What's known on the subject? and What does the study add? Positron emission tomography/computed tomography (PET/CT) with choline and fluoride for the detection of metastases in patients with prostate cancer have each been evaluated, with mixed results. Choline PET/CT has been evaluated against pelvic lymphadenectomy, generally with a low sensiti
Pregnant women often have questions concerning fetal effects of drugs but reliable information intended for them is limited. This study investigated how pregnant women perceive and value the scientific resource Drugs and Birth Defects (www.janusinfo.se/fosterpaverkan) and compared their opinions to those of health care professionals.
A decade has passed since the first human embryonic stem cell (hESC) line was established, providing immense hope in curing diseases by cell replacement therapy. For instance, in the pancreas, the insulin-producing β-cells are damaged in diabetes patients, and a successful replacement of those cells could provide a cure. These cells can be replaced by organ donation, but owing to a profound scarci
OBJECTIVE: To estimate the accuracy of endometrial thickness measurement in the detection of endometrial cancer among women with postmenopausal bleeding with individual patient data using different meta-analytic strategies. DATA SOURCES: Original data sets of studies detected after reviewing the included studies of three previous reviews on this subject. An additional literature search of publishe
Eae5 in rats was originally identified in two F-2 intercrosses, (DA x BN) and (E3 X DA), displaying linkage to CNS inflammation and disease severity in experimental autoimmune encephalomyelitis (EAE), respectively. This region overlaps with an arthritis locus, Pia4, which was also identified in the (E3 X DA) cross. Two congenic strains, BN.DA-Eae5 and BN.DA-Eae5.R1, encompassing the previously des
In 2012, the Greater Mekong Sub-region (GMS), an initiative launched by the Asian Development Bank (ADB) to promote regional integration and development between six mainland Southeast Asian countries, will reach its twentieth anniversary. Throughout the past twenty years, the GMS has been considered as highly successful, in comparison with other regional initiatives, in improving connectivity, com
We have constructed a novel neural network architecture called CWE-LSTM (concatenated word-emoji bidirectional long short-term memory) for classify- ing emotions in Twitter conversations. The architecture is based on a combina- tion of word and emoji embeddings with domain specificity in Twitter data. Its performance is compared to a current state of the art natural language process- ing model fro
This study aims to discourage error-prone intuitive thinking in decision-making for proactive adaptation to disaster risk and climate change and to encourage the realisation of well-founded proactive adaptation measures by developing a decision support tool for Swedish municipal preparedness coordinators. Using a design research methodology, the researchers interviewed preparedness coordinators fr
This thesis examines the development Forest Green Rovers has undergone since their current owner and Chairman joined the club. With a clear vision and agenda, the aim was to over time transform the club into something greater than just sporting achievements. For nearly fifteen years, the club's management has been dedicated to embedding sustainability in all aspects of the club's operation
To promote sustainable manufacturing and lower industrial emissions, GE HealthCare is constantly assessing new approaches to improve their production processes. As a global manufacturer of contrast media, their potential for positive societal impact is significant. In addition to sustainability, a pharmaceutical production process is required to deliver products of high purity. This means that the
Next-generation sequencing (NGS) has transformed the study of antibody repertoires by enabling high-throughput, in-depth analysis of immune diversity and antigen-driven selection. When paired with in vitro display technologies, NGS offers unparalleled resolution in characterizing antibody libraries, but also presents substantial computational challenges due to the highly variable nature of antibod
The Million Homes Programme, launched in Sweden during the 1960s, resulted in the construction of over one million homes to address a national housing shortage. A majority of the houses consist of linear block buildings, many of which now require renovation. Moreover, climate change and increasing energy demands have put pressure on the building sector to reduce emissions and improve energy perfor
Fire safety design for complex buildings often relies on the Performance-based Design approach which assesses the margin of safety by comparing Available Safe Egress Time with Required Safe Egress Time. However, most current modelling tools often operate independently or at most with one-way coupling. This potentially reduces the accuracy of fire safety assessments by failing to capture dynamic in
This thesis was developed in partnership with SCM Group, a leading Italian manufacturer of material-cutting machinery operating an extensive international network of production sites and clients. Because of the magnitude of its operations, SCM’s technical support teams manage a large volume of support tickets-records submitted by clients on a daily bases: structured reports documenting machine fai
Metasurfaces are two-dimensional arrays of sub-wavelength structures often arranged in a periodic lattice. During recent years, metasurfaces have emerged as one of the most promising platforms to shape electromagnetic waves using compact devices, exhibiting extraordinary control over the light amplitude, polarization and phase. Starting with metallic materials, metasurface research has shifted tow
The rapid expansion of the plant-based beverage sector has increased the demand for high-performance, barista-grade oat drinks that are capable of withstanding the thermal and acidic stresses of coffee applications. This master’s thesis, conducted in collaboration with Cerealiq AB, evaluates the efficacy of six specific enzymatic treatments in modifying the structural and physical properties of oa
The rapid public adoption of large language models (LLMs) has transformed written communication and creative production, while simultaneously creating growing concerns regarding authenticity, misinformation, and the preservation of human authorship. As AI-generated literary content becomes increasingly sophisticated, the ability to reliably distinguish machine-generated prose from authentic human
Peptide therapeutics offer advantages in specificity and affinity, yet the potential propensity to self-associate and aggregate poses a challenge for the development of stable oral formulations. This master’s thesis evaluates the utility of the fluorescent dye Thioflavin T as a structural probe to monitor the aggregation of glucagon-like peptide-1 receptor agonists, specifically Liraglutide and Se
Bioenergy is the largest energy source in the Swedish energy system, where it consists mainly of domestic forest-based biomass in the form of residues and by-products. Today, there is a general discussion about the need for changes in national forest management policies and new European Union (EU) directives and regulations for forestry and bioenergy to better fulfil biodiversity and climate targe
Reliable ankle torque measurements are important in rehabilitation, where strength assessments are used to evaluate recovery and guide treatment. Isokinetic dynamometers, such as the Biodex system, are commonly used to provide controlled measurements of joint torque. However, these measurements rely on the ankle being held in a stable and reproducible position. Mechanical play in the ankle-attachm
