Filetype
Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes that occur in response to regular exercise. Here, we perform large-scale plasma proteomic profiling in 654 healthy human study participants before and after a supe
Agricultural intensification at field and landscape scales, including increased use of agrochemicals and loss of semi-natural habitats, is a major driver of insect declines and other community changes. Efforts to understand and mitigate these effects have traditionally focused on ecological responses. At the same time, adaptations to pesticide use and habitat fragmentation in both insects and flow
We demonstrate that finite impulse response (FIR) models can be applied to analyze the time evolution of an epidemic with its impact on deaths and healthcare strain. Using time series data for COVID-19-related cases, ICU admissions and deaths from Sweden, the FIR model gives a consistent epidemiological trajectory for a simple delta filter function. This results in a consistent scaling between the
Children's interactions with nature are important mediators of health benefits and future relationships with nature and conservation. However, there are growing concerns that children are becoming disconnected from nature as societal changes make natural environments and their affordances less accessible. There is now a need to explore ways to reconnect children to nature. We evaluated bird feedin
This study assesses the potential benefit of Blue-Green Solutions (BGS), green rooftops, rain gardens, permeable pavements, and bioswales, in Lisbon, Portugal. These proposed mitigation measures are applied using TFM-DYN (Nilsson et al., 2021) to simulate potential fluvial flooding distributions from a 10- and 50-year rain event.Water depth of over 30 centimeters can cause damage to infrastructure
Background & aims: Epidemiological evidence on ultra-processed food (UPF) and cause-specific mortality remains limited and mixed. Molecular mechanisms underlying UPF intake and mortality remain unexplored. This study aimed to evaluate the associations between UPF consumption, metabolic signatures, and all-cause, premature, and cause-specific mortality. Methods: This study included 27670 partic
The European spruce bark beetle is a major disturbance agent in Norway spruce forests in Europe, and with a changing climate it is predicted that damage will increase. To prevent the bark beetle population buildup, and to limit further spread during outbreaks, it is crucial to detect attacked trees early. In this study, we utilize Sentinel-2 data in combination with a risk map, created from geodat
The TFM-DYN model represents a significant advancement from static flow accumulation estimations into dynamic hydrological modeling (Nilsson et al., 2021). It incorporates variable precipitation in time and space as input together with high-resolution topography and includes functions for friction and infiltration to produce results such as water depths, flow velocity, inundated areas, flow pathwa
Background Elevated troponin levels are a sensitive biomarker for cardiac injury. The quick and reliable prediction of troponin elevation for patients with chest pain from readily available ECGs may pose a valuable time-saving diagnostic tool during decision-making concerning this patient population. Methods and results The data used included 15 856 ECGs from patients presenting to the emergency r
Background: The incorporation of artificial intelligence (AI) into point-of-care ultrasound (POCUS) platforms has rapidly increased. The number of B-lines present on lung ultrasound (LUS) serve as a useful tool for the assessment of pulmonary congestion. Interpretation, however, requires experience and therefore AI automation has been pursued. This study aimed to test the agreement between the AI
Lean, premixed, swirl-stabilized flames are widely used in modern Dry Low Emissions gas turbine combustors; however, the turbulent combustion process under those conditions is known to be extremely sensitive and prone to instabilities. Numerical simulations can be a valuable tool in predicting the effects of alternative fuels; however, the sensitivity of the results to different models ought to be
The combustion of conventional Jet A, alongside two alternative jet fuels, C1 and C5, is simulated with Large Eddy Simulations (LES) in a generic single-cup spray combustor during idle and cruise conditions. The spray is modeled using Lagrangian particle tracking and the combustion chemistry of each fuel is modeled by skeletal reaction mechanisms. The volatility and atomizability of each fuel dire
Tropical forests provide essential ecosystem services, playing a critical role in climate regulation, biodiversity conservation, and regional hydrological cycles while also supporting livelihoods. However, they are increasingly threatened by deforestation and land-use change. Accurate land cover (LC) mapping is vital to monitor these changes, but mapping tropical forests is challenging due to comp
BACKGROUND: Atrial fibrillation (AF) is suggested to be associated with venous thromboembolism (VTE) and might thereby play a role in the development of chronic thromboembolic pulmonary hypertension (PH). By elevating left-sided filling pressure and promoting atrial myopathy, AF may also play a role in the development of postcapillary PH. We aimed to investigate the association between AF, with or
Soil protists are increasingly recognized as key players in organic matter turnover, yet their role as direct decomposers (i.e., saprotrophs) remains underexplored compared to that of bacteria and fungi. Here, we synthesize ecological, physiological, and genomic evidence to highlight the potential of protists to actively decompose organic matter and influence soil carbon cycling. We distinguish tw
BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and cardiac transplantation. We report a genome-wide association study and multi-trait analysis of DCM (14,256 cases) and three left ventricular traits (36,203 UK Biobank participants). We identified 80 genomic risk loci and prioritized 62 putative effector genes, including several with rare variant DCM associations (MAP3K7, NEDD4L a
The compositions of alternative jet fuels can vary radically, and the consequences of these differences are a subject of ongoing investigation. Numerical combustion simulations are vital to this research and require chemical reaction mechanisms that efficiently and accurately capture the chemical pathways of combustion. Here, we present the recently developed Z79 collection of small pathway-centri
