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A common type of inhalation medicine uses a dry powder formulation where the active pharmaceutical ingredient (API) is attached on the surface of carrier particles, often in combination with additional components. The spatial distribution of the API on the carrier particle is critical for the release into the lungs and thus for the efficacy of the drug. In this work, we use ToF-SIMS imaging in com

The aim of this chapter is to explore the safety value of implementing Asimov's Laws of Robotics as a future general framework that humans should obey. Asimov formulated laws to make explicit the safeguards of the robots in his stories: (1) A robot may not injure or harm a human being or, through inaction, allow a human being to come to harm; (2) A robot must obey the orders given to it by human b

Purpose of review Breathlessness is a common, distressing and limiting symptom in people with advanced disease, but is challenging to assess as the symptom intensity depends on the level of exertion (symptom stimulus) during the assessment. This review outlines how to use recently developed normative reference equations to evaluate breathlessness responses, accounting for level of exertion, for va

A naturalistic view should make us appreciate the rich possibilities of nature. This naturalistic point of departure, as formulated by Willem B. Drees, invites reflection on the relationship between nature and spirituality. Today, the concept of sustainability occupies a key role in what has come to be the greatest challenge ever that humankind has faced together at the same moment in history. Usu

The construction sector needs to transition toward using bio-based building materials in order to reduce its negative environmental impact. However, it is unclear how exactly such a bio-based future will look like, with different stakeholders in different geographical contexts having different visions of the sector’s future. Based on an extensive collection of expert interviews with stakeholders f

Contact-rich manipulation tasks remain a hard problem in robotics that requires interaction with unstructured environments. Reinforcement Learning (RL) is one potential solution to such problems, as it has been successfully demonstrated on complex continuous control tasks. Nevertheless, current state-of-the-art methods require policy training in simulation to prevent undesired behavior and later d

Objectives: An increased interest in the phenomenon and process of compassion, in both clinical and non-clinical psychological research, has been seen in recent decades. In these contexts, compassion is frequently understood as a felt response to the suffering of others that involves caring and seeing the universal nature of human suffering, as well as an authentic desire to ease the distress. Bas

We outline a framework to study the use of mathematics in physics classrooms. The framework focuses on the relations made between Reality, Theoretical models and Mathematics. In this paper the analyses of one teacher and her 3rd year classes at secondary school are presented. The results show that phenomena in reality are often used as a short prelude to put focus on the relationship theoretical m

Summary Systematic process triage quickens the treatment of the most sick patients Ugeskr Læger 2011;173(40):2490-2493 Systematic process triage is a relatively unknown concept in Denmark. Currently there are no national recommendations regarding triage models for use in the emergency department (ED). Four medium-sized EDs from different regions across the country cooperated in a joint venture to

We present a microchannel-based adaption of density-gradient centrifugation that allows the instantaneous, precise, and repeatable generation of a 1-dimensional mass-density gradient and determination of single-cell densities with integrated mass-density calibration.

Recent decades have seen an increased mobilization of LGBTQ rights in the creation and maintenance of national(ist) identities. One example is how Sweden has been cast as exceptionally progressive with regard to gender equality and LGBTQ rights, in line with earlier notions of ‘Swedish exceptionalism’. Simultaneously, military institutions across a number of countries have attempted to mobilize is

Purpose: The pin fin is applied into a Lamilloy cooling structure which is broadly used in the leading edge region of the modern gas turbine vane. The purpose of this paper is to investigate effects of the layout, diameter and shape of pin fins on the flow structure and heat transfer characteristics in a newly improved Lamilloy structure at the leading edge region of a turbine vane. Design/methodo

Purpose: The purpose of this paper is to numerically study the influence of wall conduction on the heat transfer of supercritical n-decane in the active regenerative cooling channels. Design/methodology/approach: A horizontally placed rectangular pipe with a solid zone and another one without a solid zone were used. A drastic variation of thermo-physical properties was emphatically addressed. Afte

This chapter illustrates how quantum chemical calculations can be used to elucidate structural and functional aspects of tetrapyrrole cofactors, focusing on porphyrins, cobalamins, coenzyme F430, and chlorophyll. A particular emphasis is put on the biochemical significance of axial ligands, which can tune the function of the tetrapyrroles. With the use of quantum chemical calculations, it is possi