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Preeclampsia (PE) is a pregnancy disorder characterized by systemic endothelial damage that leads to long-term cardiovascular complications. The endothelial glycocalyx (EG) covers the luminal surface of endothelium playing a critical role in vascular homeostasis. In this study we aimed to evaluate EG thickness and blood pressure (BP) trends in women with a history of PE vs. normotensive pregnancy.
Exposure to urban air pollution during early pregnancy is associated with increased risk for adverse pregnancy outcomes, such as preeclampsia (PE), and there is an urgent need to understand how air pollution affects biological mechanisms in the placenta. Hofbauer cells (HBCs) are fetal placental macrophages that regulate immune tolerance in the placenta. They are normally polarized towards an anti
Background: Previous studies suggest an antidepressant effect of omega-3 fatty acids (n-3 PUFAs). This effect may be larger in patients with low-grade inflammation, defined as mild elevations of high sensitivity C-reactive protein or other commonly used inflammatory markers. The antidepressant mechanisms of n-3 PUFAs are not fully understood but may involve modulation of immunometabolic processes
Introduction: A subgroup of severe Traumatic Brain Injury (TBI) patients, known as ultra-severe (us-TBI), is most commonly defined as a post-resuscitation Glasgow Coma Scale (GCS) of 3–5. There is uncertainty on whether these critically injured patients can benefit from neurosurgical intervention. Research question: The available evidence regarding the decision-making and outcome following managem
Background In adults with serious respiratory illness, breathlessness is prevalent and associated with reduced health-related quality of life. The aim of this review was to assess the impact of breathing techniques on breathlessness in adults with serious respiratory illness. Methods Electronic databases were searched to identify randomised controlled trials testing breathing techniques (technique
Background: Home oxygen therapy (HOT) improves survival in patients with hypoxaemic chronic respiratory disease. Most patients evaluated for HOT are former or active smokers. Oxygen accelerates combustion and smoking may increase the risk of burn injuries and fire hazards; therefore, it is considered a contraindication for HOT in many countries. However, there is variability in the practices and p
Background: Predicting severe preeclampsia with need for intensive care is challenging. To better predict high-risk pregnancies to prevent adverse outcomes such as eclampsia is still an unmet need worldwide. In this study we aimed to develop a prediction model for severe outcomes using routine biomarkers and clinical characteristics. Methods: We used machine learning models based on data from an i
Syftet med denna studie är att utifrån mitt empiriska material kartlägga och beskriva hur föräldrar till barn intagna på särskilda ungdomshemmen tolkar, definierar och upplever ett behandlingsprojekt, som involverade olika myndigheter, benämnt Motverka Våld och Gäng. Dessutom uppmärksammas hur de anställda samordnarna uppfattades och kategoriserades av föräldrarna. ”Föräldrar” blir i undersökninThe aim of this study is to analyze how mothers with children placed in Swedish juvenile homes interpret, define and perceive, on the one hand, the project “Motverka Våld och Gäng” meaning “Counteract Violence and Gangs”, and on the other hand the role of the Coordinators employed in this project. The mothers who were interviewed spoke about some Coordinators that they appreciated. They then pain
Målet med projektet var att analysera problem med arbete i kyla i mjölkproduktionsanläggningar vad gäller förekomst, frekvens och skaderisk samt att föreslå åtgärder för förbättringar. Projektet bestod av två delar: Del 1. En fältstudie, som genomfördes dels i Uppsalatrakten, dels i Västerbottens län. Del 2. En enkätstudie, riktad till Lantbrukshälsans medlemmar i norra regionen. Fältstudierna omfThe aim of the project was to analyse problems with cold when working in dairyfarms with respect to prevalence, frequency and risk for injuries and to propose measures for improvements of thermal conditions. The project comprised two parts: a field study and a questionnaire survey. The field studies were performed at seven dairy-farms in the Uppsala region and six dairy-farms in the northern regio
Generative product design systems used in the context of mass customization are required to generate diverse solutions quickly and reliably without necessitating modification or tuning during use. When such systems are employed to allow for the mass customization of product form, they must be able to handle mass production and engineering constraints that can be time-consuming to evaluate and diff
OBJECTIVES: To investigate the mechanisms of platelet kinetics in the SMART study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) (drug conservation [DC]) compared to continuous treatment (viral suppression [VS]). Follow up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART.
Popular Abstract in Swedish Under det senaste årtiondet har förekomsten av läkemedel i miljön rönt stor uppmärksamhet. Studier har visat att flera läkemedel hittats i sjöar och vattendrag och kan förorsaka negativa effekter hos vattenlevande organismer. Den i särklass största vägen via vilken läkemedel når miljön är avloppsreningsverk. Efter att vi ätit ett läkemedel kommer kroppen också att utsönThis thesis addresses the application of hollow fiber liquid phase microextraction as a simple, efficient and environmentally friendly tool to study the fate of four common anti-inflammatory drugs (ketoprofen, naproxen, diclofenac and ibuprofen) during wastewater treatment. Initial experiments verified that this technique is applicable on aqueous as well as suspensions of solid samples, thus great
A genetic algorithm for optimal placement of optical fibers in arbitrary geometries for interstitial photodynamic therapy has been developed. Based on calculated fiber positions, the diffuse light distribution is simulated by solving the diffusion equation by means of the finite element method and the treatment time is calculated. Utilizing an instrument for interstitial photodynamic therapy that
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development, but the relative importance of different cellular sources of PDGFB has not been established. Using Cre-lox techniques, we show here that genetic ablation of Pdgfb in endothelial cells leads to impaired recruitment of pericytes to blood vessels. The endothelium-restricted Pdgfb knockout mutants also develop
BACKGROUND: Increased intraocular pressure (IOP) has been shown to be one of the most important risk factors for developing glaucoma. Yet it has not been clearly demonstrated that IOP-lowering treatment can reduce the incidence of glaucoma damage in patients with ocular hypertension. The aim of the current paper was to report the results of a long-term study addressing this very problem.METHODS: W
Samverkansavtal_inlaga 1 U TV EC K LIN G I SA M V ER K A N 2003 Samverkansavtal om arbetsmiljö och medbestämmande Genom engagerade medarbetare som tar ansvar för sitt arbete får länets invånare bättre service. Ledarskap och arbetsorganisation ska ge förut- sättningar för delaktighet och inflytande. Det viktigaste stödet för ökat personalinflytande tillkom 1993 då de landstingscentrala parterna trä
Background: Acute kidney injury (AKI) is a serious complication of out-of-hospital cardiac arrest (OHCA). Post-resuscitation cardiogenic shock (CS) is a key contributing factor. Targeting a higher arterial carbon dioxide tension may affect AKI after OHCA in patients with or without CS. Methods: Pre-planned exploratory study of a multi-national randomised trial comparing targeted mild hypercapnia o
We present a newly funded research program, DESCRYPT, aimed at deciphering and analyzing historical texts with rare or unknown scripts. The project leverages advancements in computational linguistics, artificial intelligence (AI), and image processing, alongside traditional philological methods, to develop innovative tools for transcription, recognition, and interpretation of historical writings w
Popular Abstract in Swedish Reglering och kommunikation med störande brus Hur kan man på bästa möjliga sätt skicka data, till exempel en ljudsignal, när kommunikationen störs av brus och ändå måste ske snabbt? Och hur kan man på bästa sätt styra en process när styrsystemet begränsas av dålig kommunikation? Dessa frågor har undersökts i avhandlingen Control and Communication with Signalto-Noise This thesis is about two problems in the intersection of communication and control theory. Their common feature is that they involve communication over an additive white noise channel with a signal-to-noise ratio (SNR) constraint. The first problem concerns the transmission of a real-valued signal from a partially observed Markov source. The distortion criterion is the mean squared error and the
BACKGROUND: Pramipexole, a dopamine agonist, has demonstrated antidepressant efficacy as an augmentation strategy in unipolar and bipolar depression. However, dopaminergic treatments are associated with impulse control disorders, including gambling disorder, and evidence regarding behavioural risks in psychiatric populations remains limited.METHODS: We conducted a nationwide register-based cohort
