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This chapter addresses the organization known as the Satanic Reds, which was founded in the latter half of the 1990s by Tani Jantsang and Philip Marsh. The organization has been described as a ”virtual audience cult,” and even though it is clear that several people have contributed in shaping it, the organization has been especially influenced by its two founders. Jantsang and Marsh have spoken fo
Despite the plethora of information on (S)-selective amine transaminases, the (R)-selective ones are still not well-studied; only a few structures are known to date, and their substrate scope is limited, apart from a few stellar works in the field. Herein, the structure ofLuminiphilus syltensis(R)-selective amine transaminase is elucidated to facilitate engineering towards variants active on bulki
Aims: To evaluate the cost-effectiveness of bimekizumab, an inhibitor of IL-17F and IL-17A, against biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARD) for psoriatic arthritis (PsA) from the Swedish healthcare system perspective. Materials and methods: A Markov model was developed to simulate the clinical pathway of biologic [b] DMARD-naïve or tumor necrosis factor inhibi
This study constructs a Sustainable Halal Tourism Composite Performance Index (SHTCPI) to evaluate the progress of the global halal tourism industry from a sustainable tourism perspective. To create the SHTCPI, this study uses four dimensions (environment, social, economic, and halal tourism) and 24 indicators covering the 2010 to 2020 period and 116 countries. The findings suggest that halal tour
In photoacoustic imaging, the amplitude of the photoacoustic signal is used for mapping the spatial distribution of a chromophore in the body and few studies have focused on the potential of using frequency content of the photoacoustic data. This study investigates the feasibility of using the photoacoustic center frequency spectrum in differentiating microspheres of various sizes and colors in ph
Since Xi Jinping came to power in 2012, the People's Republic of China has been on a mission to break what it describes as ‘Western hegemony’ around global norms. Beijing is engaged in a struggle to strengthen its influence in global governance and has identified increasing China's ‘discourse power’ at the United Nations (UN) as key to achieving this goal. Focused on human rights, this paper exami
The clinical translation of photosensitizers based on ruthenium(II) polypyridyl complexes (RPCs) in photodynamic therapy of cancer faces several challenges. To address these limitations, we conducted an investigation to assess the potential of a cubosome formulation stabilized in water against coalescence utilizing a polyphosphoester analog of Pluronic F127 as a stabilizer and loaded with newly sy
Introduction Deep learning models for detecting episodes of atrial fibrillation (AF) using rhythm information in long-term ambulatory ECG recordings have shown high performance. However, the rhythm-based approach does not take advantage of the morphological information conveyed by the different ECG waveforms, particularly the f-waves. As a result, the performance of such models may be inherently l
Objective: Secundum atrial septal defect (ASD II) is a common congenital heart defect, and interatrial communications among preterm children is even more common. The objective of this study was to calculate the incidence of ASD II in children, with assessment to gestational age at birth. Further, to assess maternal, prenatal and postnatal risk factors associated with ASD II among children of diffe
Precision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison with contemporary practice, while maintaining safety and cost-effectiveness. The etiology, clinical manifestation and prognosis of diseases such as obesity, diabetes, cardiovascular disease, kidney disease and fatty liver disease are heterogeneous. Without standardized reportin
A statistical combination of various searches for pair-produced leptoquarks is presented, using the full LHC Run 2 (2015–2018) data set of 139 fb−1 collected with the ATLAS detector from proton–proton collisions at a centre-of-mass energy of s=13 TeV. All possible decays of the leptoquarks into quarks of the third generation and charged or neutral leptons of any generation are investigated. Since
The paper introduces a new device for analyzing, teaching, and training jaw movements: the MARRYS helmet. We outline the motivation for the development of the helmet, describe its key advantages and features relative to those of the Electromagnetic Articulograph (EMA) and illustrate by means of selected study portraits the possible uses of the MARRYS helmet in the various fields of the empirical a
The vision of birds has been extensively studied, and alot is known about what they are able to see contrast sensitivity and acuity, in different light intensities, is known Still, visual perception depends on a combination of many stimulus parameters, which can make it difficult to predict the visibility of ecologically relevant stimuli.In this doctoral thesis I have investigate visual thresholds
The term ‘artificial intelligence’ has arguably come to function in political discourse as, what Laclau called, an ‘empty signifier’. This article traces the shifting political discourse on AI within three key institutions of global governance–OHCHR, WHO, and UNESCO–and, in so doing, highlights the role of ‘crisis’ moments in justifying a series of pivotal re-articulations. Most important has been
Brazil has faced severe droughts in recent decades, significantly affecting agriculture, water supply, and hydropower generation, among other sectors. The Paraná River Basin, a major hub for hydropower, has been particularly affected, posing challenges for water management. To address this, we conducted a study to provide tailored climate information for the Brazilian hydroelectric sector. Given t
