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Receptors for the neurotransmitter and neuroendocrine peptides, vasoactive intesinal peptide (VIP) and secretin, both belong to the Type B subfamily of G-protein-coupled receptors. This group is evolutionally as well as structurally distinct from the much larger Type A, or rhodopsin-type, subfamily. We have mapped the ligand-activating epitopes of the human VIP1 receptor by the use of hybrid recep

We present a qualitative physical model of the origin of two very brightUV lines of Fe II at 2507-2509 Å, present in high-resolutionspectra of gaseous condensations (blobs) close to the central star ofeta Carinae. The spectra have been obtained with the Hubble SpaceTelescope (HST). The model is based on a type of Bowen mechanism withselective photoexcitation of Fe II by a broad HLyalpha profile,ge

Microsphere-based constitutive models are a helpful tool in the modelling of materials with a microstructure composed of contributing elements directionally arranged. This is the case, for instance, for fibred soft tissues. In these models, the macroscopic mechanical behaviour is obtained from the integration of the micro-structural contribution of each component (e.g. each fibre) over the surface

Cerebral ischemia that develops after subarachnoid hemorrhage (SAH) carries high morbidity and mortality. Inflammatory mediators are involved in the development of cerebral ischemia through activation of the mitogen-activated protein kinase pathway. We hypothesized that blockade of the MAPkinase/ERK (MEK)/extracellular signal-regulated kinase (ERK) pathway upstream with a specific raf inhibitor wo

ISIS committed mass atrocities against the Yazidis (Kurdish: Êzîdîs) in Sinjar (Kurdish: Şingal), Iraq, in 2014-2017. Several international and regional observers have qualified the acts as genocide under international law. Yet the numerous social, cultural, and political preconditions of the genocide are not recognized in the 1948 Genocide Convention. To answer the line of question, Susan Opotow’

Horisonter med subfossila stubbar och rötter av tall (Pinus sylvestris) är vanliga i stratigra-fier från torvmarker i norra Europa. Dessa är tydliga indikationer på att det under holocen funnits perioder med tillräckligt gynnsamma förhållanden för tallar att växa på mossar. Tall kan endast växa på mossar när ytan är tillräckligt torr, och därför är rester av tallar på mossar goda indikationer på eHorizons rich in subfossil stumps and roots of Scots pine (Pinus sylvestris) are frequently found in stratigraphies of northern European peatlands, providing clear evidence of Holocene periods with favourable conditions for bog-pine growth. The pines could only grow when bog-surface wetness was sufficiently low, and the presence of their remains is therefore a good indicator of past climatic condi

We studied the physiological, metabolic and hormonal mechanisms underlying the elevated risk of type 2 diabetes in carriers of TCF7L2 gene. We undertook genotyping of 81 healthy young Danish men for rs7903146 of TCF7L2 and carried out various beta cell tests including: 24 h glucose, insulin and glucagon profiles; OGTT; mixed meal test; IVGTT; hyperglycaemic clamp with co-infusion of glucagon-like

The two-body photodisintegration of He-3 has been investigated using tagged photons with energies from 14-31 MeV at MAX-lab in Lund, Sweden. The two-body breakup channel was unambiguously identified by the (nonsimultaneous) detection of both protons and deuterons. This approach was made feasible by the overdetermined kinematic situation afforded by the tagged-photon technique. Proton-and deuteron-

This study uses a specifically constructed sub-national dataset on Ebola Virus Disease (EVD) outbreak cases, deaths, and CFR in order to look at the question of how important various socio-economic factors were in determining the intensity and severity of the 2013-2016 EVD outbreak in Guinea, Liberia, and Sierra Leone. The results of the OLS model shows that the socio-economic conditions in differ

This paper aims to examine the arguments proposed by the Obama administration regarding a U.S. military intervention in Syria due to the use of chemical weapons by the Syrian regime in 2013. During his presidency, Obama stated that the He draws a ‘red line’ at the use of chemical weapons against civilians, but the threat proved to be empty a year later when thousands of people were killed in a che

Through an idea analysis that utilizes an ideal type of populism, this study seeks to find out how the use of populist ideas has changed over time in conference speeches by four consecutive Labour Party leaders between the years 1998 and 2018. The method for this idea analysis is based on Göran Bergström’s and Per-Anders Svärd’s theories on an ideal type-based idea analysis. The theoretical framew

The convergence of advances in medical science, human biology, data science and technology has enabled the generation of new insights into the phenotype known as ‘diabetes’. Increased knowledge of this condition has emerged from populations around the world, illuminating the differences in how diabetes presents, its variable prevalence and how best practice in treatment varies between populations.

The convergence of advances in medical science, human biology, data science, and technology has enabled the generation of new insights into the phenotype known as "diabetes." Increased knowledge of this condition has emerged from populations around the world, illuminating the differences in how diabetes presents, its variable prevalence, and how best practice in treatment varies between population

Austria, Finland and Sweden became members of the EU in 1995. This paper examines how support for the euro and trust in the European Central Bank (ECB) have evolved in these three countries since their introduction at the turn of the century. Support for the euro in the two euro-area members Austria and Finland has remained high and relatively stable since the physical introduction of the new curr

The armed conflict shaped and determined land-uses, water access and social and environmental norms in highlands regions in Colombia for several decades. The withdrawal of the Revolutionary Armed Forces of Colombia (FARC) after the Peace Agreement with the government of Colombia in 2016, has brought new dynamics in access and uses of land leading to increasingly visible social-environmental impact

Rationale and Objectives: The effects of locally delivered angiogenic factors or stem cells on the coronary artery perfusion territory are not well defined. Therefore, the aim of this study was to determine the ability of the selective injection of magnetic resonance contrast media (MR-CM) to map and quantify the territories of the major coronary arteries. Materials and Methods: Selective coronary