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Many studies in traditional business model (BM) literature acknowledge that it is hard for incumbent firms to change their business models, a finding echoed in the business model innovation for sustainability (BMIfS) literature. Large incumbent firms often lack or have weak capabilities needed for sustainability-driven business model innovation. This paper addresses how capabilities for such innov
Im März 1847 erließ Papst Pius IX die Enzyklika „Praedecessores Nostros“, die die katholische Geistlichkeit weltweit aufrief, zur Linderung der großen irischen Hungersnot drei Tage der Gebete und Kollekten abzuhalten. Die Bischöfe, die diese Botschaft in den italienischen Staaten weiterführten, verfassten ihrerseits Appelle zur lokalen Durchführung des Triduums. Sie animierten die Gläubigen, dem B
Objective To investigate the admission rate to neonatal care and neonatal morbidity after maternal use of antipsychotics during pregnancy. Design A population-based register study. Setting Information on all singleton births between July 2006 and December 2017 in Sweden including data on prescription drugs, deliveries and infants' health was obtained from the Swedish Medical Birth Register, the Pr
The Danish Renewable Energy Act features several financial incentive structures with direct local level implications. One of these is the wind farm co-ownership scheme, WCS. In this study, we explore local perceptions of the WCS via survey data collected during the Danish near-shore bid for tender in 2015 from almost 2000 respondents. Empirical evidence suggests that demographic facts, such as gen
AIMS: Reduced lung function and adverse health outcomes are often observed. This study characterizes genetic susceptibility for reduced lung function and risk of developing a range of adverse health outcomes.METHODS: We studied 27,438 middle-aged adults from the Malmö Diet and Cancer study (MDCS), followed up to 28.8 years. Trait-specific Polygenic scores (PGS) for forced expiratory volume in 1 s
PurposeMagnetization transfer saturation (MTsat) is a useful marker to probe tissue macromolecular content and myelination in the brain. The increased B1+ inhomogeneity at 7T and significantly larger saturation pulse flip angles which are often used for postmortem studies exceed the limits where previous B1+correction methods are applicable. Here, we develop a calibration-based correction model
Engaging students in active participation and collaborative learning is an important pedagogical component of teaching and learning in higher education. Teachers use a variety of activities to engage students, such as interactive lectures, presentations, group activities, and projects. A metaphorical understanding of the teaching-learning process may help in the implementation of innovative and gr
Advanced instrumentation and versatile setups are needed for understanding light interaction with biological targets. Such instruments include (1) microscopes and 3D scanners for detailed spatial analysis, (2) spectral instruments for deducing molecular composition, (3) polarimeters for assessing structural properties, and (4) goniometers probing the scattering phase function of, e.g., tissue slab
The Summary for Urban Policymakers (SUP) initiative provides a distillation of the IPCC reports into accessible and targeted summaries that can help inform action at city and regional scales. Volume I in the series, What the Latest Physical Science of Climate Change Means for Cities, identified the ways in which human-induced climate change is affecting every region of the world, and the cities an
Sodium fluoroacetate (FA) is a metabolic poison that systemically inhibits the tricarboxylic acid (TCA) cycle, causing energy deficiency and ultimately multi-organ failure. It poses a significant threat to society because of its high toxicity, potential use as a chemical weapon and lack of effective antidotal therapy. In this study, we investigated cell-permeable succinate prodrugs as potential tr
The fundamental importance of membrane proteins in drug discovery has meant that membrane mimetic systems for studying membrane proteins are of increasing interest. One such system has been the amphipathic, negatively charged poly(styrene-co-maleic acid) (SMA) polymer to form "SMA Lipid Particles" (SMALPs) which have been widely adopted to solubilize membrane proteins directly from the cell membra
This chapter explores the facilitation of reflective practice to aid and guide educators seeking to develop these soft skills and to assist them in developing educational programmes in the international classroom. Knowledge about learning, teaching, and education is a basic requirement. Few institutions, if any, would dispute the need for teaching staff to have an inventory of skills and expertise
Enzyme-responsive hydrogels, formed by step growth photopolymerization of biscysteine peptide linkers with alkene functionalized polyethylene glycol, provide interesting opportunities as biomaterials and drug delivery systems. In this study, we developed stimuli-responsive, specific, and cytocompatible hydrogels for delivery of anti-inflammatory drugs for the treatment of inflammatory skin disease
In 1968, Swedish insurance company Folksam launched the information campaign Front mot miljöförstöringen (“Front against Environmental Degradation”). The campaign culminated in 1969 with large public hearings where young people addressed local politicians and industry leaders about environmental problems. Throughout this campaign, the aim was to activate youth and make them co-creators of large-sc
Clinical pain is often linked to poor body mechanics, with individuals sometimes presenting multiple painful disorders. Such disorders may be influenced by behaviors that affect the general resiliency and health of the musculoskeletal system. We aimed to develop a self-reported scale using the Malmö Diet and Cancer Study questions on work-related body mechanical exposures. An expert panel identifi
The release of inorganic elements, especially K, Cl, and S, can cause severe damage to biomass conversion devices, such as slagging, fouling, or corrosion. A predictive model for the release of K-Cl-S elements can be used to enhance the design and operating conditions of biomass conversion devices. In this study, a detailed model is developed that includes 12 solid species and 13 reactions, which
Multiplanet systems are valuable arenas for investigating exoplanet architectures and comparing planetary siblings. TOI-1246 is one such system, with a moderately bright K dwarf (V = 11.6, K = 9.9) and four transiting sub-Neptunes identified by TESS with orbital periods of 4.31, 5.90, 18.66, and 37.92 days. We collected 130 radial velocity observations with Keck/HIRES and TNG/HARPS-N to measure pl
Transition metals such as copper and zinc are essential elements required for the survival of most organisms, from bacteria to humans. Yet, elevated levels of these elements are highly toxic. The Copper TRansporter protein family (CTRs) represents the only identified copper uptake proteins in eukaryotes and hence serves as key components for the maintenance of appropriate levels of the metal. More
