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The Epithelial Science Expert Group convened on 18–19 October 2023, in Naples, Italy, to discuss the current understanding of the fundamental role of the airway epithelium in asthma and other respiratory diseases and to explore the future direction of patient care. This review summarises the key concepts and research questions that were raised. As an introduction to the epithelial era of research,

In their most extreme form, sex chromosomes exhibit a complete lack of genetic recombination along much of their length in the heterogametic sex. Some recent models explain the evolution of such suppressed recombination by the "sheltering"of deleterious mutations by chromosomal inversions that prevent recombination around a polymorphic locus controlling sex. This sheltering hypothesis is based on

This article examines the narratives associated with the “Shekou Model” in China’s development of the Hambantota International Port in Sri Lanka. Through a dual narrative analysis and policy evaluation approach utilizing official Chinese and Sri Lankan statements, it examines the motivations of the Chinese Communist Party and the China Merchants Group in “selling” the Shekou Model and how Sri Lank

Protein maldigestion and malabsorption lead to malnutrition and are a feature of exocrine pancreatic insufficiency (EPI). Although it is the current standard, measurement of nitrogen in stool to assess protease activity is indirect. Up to 80% of hydrolysed proteins appear in blood in the form of peptides, so we developed a method to measure peptide-derived amino acids in plasma as a relevant measu

Semiconductor double quantum dots (DQD) coupled to superconducting microwave resonators offer a promising platform for the detection of single microwave photons. In previous works, the photodetection was studied for a monochromatic source of microwave photons. Here, we theoretically analyze the photodetection of single microwave pulses. The photodetection in this case can be seen as a nonlinear fi

Industry 4.0 concepts have recently significantly supported transparency and reliability in every industrial sector. Organizations must adapt their traditional paradigms and approaches to align with market demands. Hence, developing a framework that can change these conventional approaches with fresh ideas is essential. The Industry 4.0 (I4.0) readiness model presents a creative concept that holds

Around midnight of 9 January 1959, the Vega de Tera dam broke, releasing nearly 8 million cubic metres of water that destroyed the Spanish town of Ribadelago, killing 144 people. To this day, it remains the worst dam-related failure of the past two centuries of Spanish history. In this chapter we expand the time frame of the disaster, moving from a one-day narrative to focus on the processes of re

BACKGROUND: Achalasia is a rare motility disorder of the esophagus. The diagnosis involves clinical suspicion based on history details and results of high-resolution manometry (HRM) as recommended by the Chicago classification (CCv4.0). Interpreting data obtained through HRM can be complex especially for the novice user.METHODS: We propose therefore a color-based algorithm involving the "reversed

One of the main challenges as the market for fully commercial electrified vehicles quickly expands is predicting the electromagnetic interference (EMI) in traction voltage systems (TVSs) in differential mode (DM) and common mode (CM). The number of subsystems connected to vehicle TVSs is increasing, and thus, so are the electromagnetic compatibility (EMC) requirements. These requirements should ma

Occupancy is one of the primary contributors to the energy performance gap, defined as the difference between actual and predicted energy usage, in buildings. This paper limits its scope to residential buildings, where occupant-centric consumption often goes unaccounted for in standard energy metrics. This paper starts from the hypothesis that a simple occupant energy efficiency label is needed to

Aim of the review: To provide an overview of studies that have published dataregarding region and population size, procedure location, team composition, inclusionand exclusion criteria, outcome parameters, and cost–benefit analyses onextracorporeal membrane oxygenation use for refractory out-of-hospital cardiac arrest.Data sources: A structured systematic literature search of articles published pr

Objective: This study was undertaken to develop and characterize a multiplex immunoassay for detection of autoantibodies against peptides derived from proteins known to play a role in development of arthritis and that are also expressed in joints. Methods: We selected peptides from the human counterpart of proteins expressed in the joints, based on mouse models that showed these to be targeted by

We present the first systematic comparison of the charged-particle pseudorapidity densities for three widely different collision systems, pp, p–Pb, and Pb–Pb, at the top energy of the Large Hadron Collider (sNN=5.02TeV) measured over a wide pseudorapidity range (−3.5

INTRODUCTION: Hip and knee osteoarthritis (OA) are increasingly common with a significant impact on individuals and society. Non-pharmacological treatments are considered essential to reduce pain and improve function and quality of life. EULAR recommendations for the non-pharmacological core management of hip and knee OA were published in 2013. Given the large number of subsequent studies, an upda

Background: Antibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in cerebrospinal fluid (CSF), aiding in the diagnosis of AD. Mass spectrometry enables absolute quantification of multiple p-tau variants within a single run. The goal of this study was to compare the performance of mass spectrometry assessments of p-tau181, p-

Considerable time is often spent optimizing antennas to meet specific design metrics. Rarely, however, are the resulting antenna designs compared to rigorous physical bounds on those metrics. Here, we study the performance of optimized planar meander line antennas with respect to such bounds. Results show that these simple structures meet the lower bound on the radiation quality factor (Q-factor)