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Paper for the Public and Social Innovation Conference (PUBSIC), Lillehammer University College, Lillehammer, Norway, 15-17 November, 2017 Theme 7B: managing and evaluating sustainable innovation In search of a model for sustainable innovation in welfare services Katja Lindqvist & Ulrika WestrupDepartment of Service Management and Service Studies, Lund University, Swedenkatja.lindqvist@ism.lu.s
AIMS/HYPOTHESIS: The molecular mechanisms of insulin release are only partially known. Among putative factors for coupling glucose metabolism to insulin secretion, anaplerosis has lately received strong support. The anaplerotic enzyme pyruvate carboxylase is highly expressed in beta cells, and anaplerosis influences insulin secretion in beta cells. By inhibiting pyruvate carboxylase in rat islets,
LTRs of endogenous retroviruses are known to affect expression of several human genes, typically as a relatively minor alternative promoter. Here, we report that an endogenous retrovirus LTR acts as one of at least two alternative promoters for the human beta1,3-galactosyltransferase 5 gene, involved in type 1 Lewis antigen synthesis, and show that the LTR promoter is most active in the gastrointe
The (p)ppGpp-mediated stringent response is a bacterial stress response implicated in virulence and antibiotic tolerance. Both synthesis and degradation of the (p)ppGpp alarmone nucleotide are mediated by RelA-SpoT Homolog (RSH) enzymes which can be broadly divided in two classes: single-domain ‘short’ and multi-domain ‘long’ RSH. The regulatory ACT (Aspartokinase, Chorismate mutase and TyrA)/RRM
Angiogenesis and increased permeability of the blood-brain barrier have been reported to occur in animal models of Parkinson's disease and l-dopa-induced dyskinesia, but the significance of these phenomena has remained unclear. Using a validated rat model of l-dopa-induced dyskinesia, this study demonstrates that chronic treatment with l-dopa dose dependently induces the expression of vascular end
The importance of tyrosine residues in ligand-mediated endocytosis of the platelet-derived growth factor beta-receptor was analyzed using a series of tyrosine residue-mutated beta-receptors, which together cover all of the tyrosine residues in the juxtamembrane segment, the kinase insert, and the carboxyl-terminal tail; also certain of the tyrosine residues within the first and second parts of the
The evolutionary biologist Julian Huxley (1887–1975) attempted to promote a “religion for the future,” which he would come to refer to as Transhumanism. It was Huxley’s firm belief that mankind needed a unifying system of thought that could motivate action and change. Transhumanism was also an attempt to unite a more traditional humanistic view of the human as containing some form of core essence
AbstractAim The aim of this thesis was to evaluate the treatment and follow-up of patients undergoing hypospadias surgery at the Department of Plastic and Reconstructive Surgery, Skåne University Hospital, Malmö, in an attempt to improve the overall care of these patients. It also aimed to investigate the tissue properties of the urethral plate and deep chordee in hypospadias patients with signifi
The design and construction of large infrastructure projects require detailed information on subsurface geology and identification of potential risks. Geophysical investigations can provide important information for design and risk assessment provided that the optimal method and interpretation approach is adopted.This work presents results from seismic refraction surveys carried out along a planne
