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Abstract Background: Current prognostic molecular markers for epithelial ovarian cancer (EOC) are insufficient. The aim of the current study was to investigate the role of Sox11 in EOC Methods: Using an in silico transcriptomic screen Sox11 was identified as a potential EOC biomarker. Sox11 protein expression was evaluated using immunohistochemistry (IHC) in 76 EOC cases, which were analyzed using
This thesis focuses on developing and characterizing novel models for studying osteoclasts with an emphasis on how mutations abolishing osteoclastic acidification affect osteoclast signaling and bone remodeling, as well as how to treat patients bearing these rare mutations. Bone remodeling is under normal circumstances a tightly balanced process where resorption of bone by osteoclasts is followed
Populärvetenskaplig sammanfattning Ska du flyga långt med de där vingarna? Vissa fåglar flyger långt, andra inte. Silvertärnorna flaxar med vingarna från Arktis till Antarktis medan pingvinerna använder vingarna för att simma och inte flyger alls. Eftersom att olika fåglar använder sina vingar på så olika sätt så har nämnda vingar anpassats efter vingbärarnas behov. Vissa studier har visat sambaAbstract Bird wings are adapted to the needs of the birds and bird wings therefore differ between species, but also between ages and sexes. In this thesis, an interspecific analysis investigating relations between measurements of wing shape for birds within the Sylviidae-family, revealed strong connections between morphologically unrelated measurements. Long distances (compared to the wing length
We investigated the function of cyclin-dependent kinase 2 (Cdk2) in neural progenitor cells during postnatal development. Chondroitin sulfate proteoglycan (NG2)-expressing progenitor cells of the subventricular zone (SVZ) show no significant difference in density and proliferation between Cdk2-/- and wild-type mice at perinatal ages and are reduced only in adult Cdk2 -/- mice. Adult Cdk2-/- SVZ ce
OBJECTIVE: Nonalcoholic fatty liver disease (i.e., increased intrahepatic triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue lipolysis and hepatic de novo lipogenesis (DNL) are the main pathways contributing to IHTG. We hypothesized that dietary macronutrient composition influences the pathways, mediators, and magnitude of weight gain-induced ch
Background: The importance of alerting health care systems of patients carrying multidrug-resistant bacteria (MRB) is highlighted in numerous guidelines. In the absence of electronic alert systems, notification cards are often recommended, but have rarely been evaluated. We evaluated patient experiences of receiving and using a methicillin-resistant Staphylococcus aureus (MRSA) notification card.
Smooth muscle cell (SMC) proliferation is a key process in stabilization of atherosclerotic plaques, and during restenosis after interventions. A clearer understanding of SMC growth regulation is therefore needed to design specific anti-proliferative therapies. Retinoic acid has been shown to inhibit proliferation of SMCs both in vitro and in vivo and to affect the expression of extracellular matr
Recent data shows that fibroblast growth factor 14 (FGF14) binds to and controls the function of the voltage-gated sodium (Nav) channel with phenotypic outcomes on neuronal excitability. Mutations in the FGF14 gene in humans have been associated with brain disorders that are partially recapitulated in Fgf14(-/-) mice. Thus, signaling pathways that modulate the FGF14:Nav channel interaction may be
Succinate:quinone reductases are membrane-bound enzymes that catalyze electron transfer from succinate to quinone. Some enzymes in vivo reduce ubiquinone (exergonic reaction) whereas others reduce menaquinone (endergonic reaction). The succinate:menaquinone reductases all contain two heme groups in the membrane anchor of the enzyme: a proximal heme (heme b(P)) located close to the negative side of
Sustainability is an increasingly important topic across the world, and awareness of it has been growing since the publication of the UN sustainable development goals (SDGs). Seeing an escalating societal interest in sustainability, consumer demand for sustainable products in retailer’s assortments. Making the retail store manager a key player for implementing Corporate Social Responsibility (CSR)
Rural depopulation is a concern in many countries, and various policy initiatives have been taken to combat such trends. This article examines whether hidden potential for rural population growth can be found in Sweden. If such potential exists, it implies that the development prospects for many rural areas are not as unpromising as they may seem today. If not, rapid rural depopulation can be expe
Background: Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes. Results: In two cohorts of primary breast cancers, PKC alpha levels correlated to estrogen and progesterone receptor negativity, tumor grade, and proliferative activity, whereas PKC delta a
Våren 2000 enades Europeiska Rådet om att senast år 2010 ha förvandlat Europa till världens mest konkurrenskraftiga kunskapsbaserade ekonomi. Riktlinjerna samlades i den s.k. Lissabonstrategin. Genom att kritiskt granska dokument som producerats inom ramen för Kommissionens agenda i2010: "Ett informationssamhälle för tillväxt och konkurrens" vill jag synliggöra hur EU beskriver informat
Humanity injects an almost incomprehensible 42 billion tonnes of carbon dioxide (CO₂) into the atmosphere every year. The majority of this comes from burning fossil fuels, but a substantial portion, about 16%, arises from how we use the land. Most of these land-use emissions are caused by deforestation, particularly in the tropics.In order to slow climate change, the global community needs to redu
