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The glycosylation status of IgG has been implicated in the pathology of rheumatoid arthritis. Earlier, we reported the identification of a novel secreted endo-beta-N-acetylglucosaminidase (EndoS), secreted by Streptococcus pyogenes that specifically hydrolyzes the beta-1,4-di-N-acetylchitobiose core of the asparagine-linked glycan of human IgG. Here, we analyzed the arthritogenicity of EndoS-treat

For efficient treatment of many diseases of the lung, it is beneficial to deliver the medicine to the respiratory tract directly. This ensures a rapid response since it can enter the bloodstream directly through the alveolar epithelium. Consequently, also decreases systemic effects due to the local treatment. Dry powder inhaler (DPI) is today one of the most used inhalers for pulmonary delivery.

Cryogels have been demonstrated to be efficient when applied for protein isolation. Owing to their macroporous structure, cryogels can also be used for treating particle-containing material, e.g. cell homogenates. Another challenging development in protein purification technology is the use of molecularly imprinted polymers (MIPs). These MIPs are robust and can be used repeatedly. The paper presen

Primary immune thrombocytopenia is an autoimmune disease associated with a reduced peripheral blood platelet count. The phenotype is variable with some patients suffering no bleeding whilst others have severe bleeding which may be fatal. Variability in clinical behaviour and treatment responses reflects its complex underlying pathophysiology. Historically the management has relied heavily on immun

Rh immune globulin (WinRho SDF; Cangene, Mississauga, ON, Canada) is an effective treatment for autoimmune thrombocytopenic purpura; however, maintaining a sustained supply for its use in autoimmune thrombocytopenic purpura and its primary indication, hemolytic disease of the newborn, makes the development of alternative reagents desirable. We compared Rh immune globulin and 6 human monoclonal ant

The link between gender and activism has been a theme in research about social movements. However, scholarly debates miss to critically reflect upon discursive constructions about women in revolutionary contexts in the global south. This study analyses the portrayal of Sudanese women in the digital space during the Sudanese revolution in 2018/2019 by focusing on the chronology and turning points o

As a consequence of agricultural intensification, large areas of species-rich grasslands have been lost and farmland biodiversity has declined. Previous studies have shown that the continuity of grazing management can have a significant influence on the environmental conditions and the levels of plant species diversity in grassland habitats. The preservation of species-rich grasslands has become a

Sixty-four patients with active distal ulcerative colitis participated in a multicentre, randomized, investigator-blind trial to compare the effect of budesonide enema, 2 mg/100 ml, with prednisolone disodium phosphate enema, 31.25 mg/100 ml. Budesonide is a new potent corticosteroid with a rapid first-pass elimination. The patients were treated for 4 weeks, and the efficacy of the drugs were eval