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α1-microglobulin (A1M) is a 26 kDa plasma and a tissue protein belonging to the lipocalin family. The reductase and free radical scavenger A1M has been shown to protect cells and extracellular matrix against oxidative and irradiation-induced damage. The reductase activity was previously shown to depend upon an unpaired cysteinyl side-chain, C34, and three lysyl side-chains, K92, 118, and 130, loca
Background: Health care providers in many countries have delivered interventions to improve physical activity levels among their patients. Thus far, less is known about the population's interest to increase their physical activity levels and their opinion about the health care provider's role in physical activity promotion. The aims of this paper were to investigate the self-reported physical acti
Objectives: To study signs of obstructive airway disease (OAD) in patients with primary Sjögren's syndrome (pSS) using the forced oscillation technique (FOT). Method: Thirty-seven female pSS patients (median age 64, range 38-77 years) without previous physician-diagnosed OAD, participating in a longitudinal follow-up study of pulmonary function, and 74 female population-based controls (median age
Background. Sunlight exposure and fair skin are major determinants of human vitamin D production, but they are also risk factors for cutaneous malignant melanoma (MM). There is epidemiological evidence that all-cause mortality is related to low vitamin D levels. Methods. We assessed the avoidance of sun exposure as a risk factor for all-cause mortality for 29 518 Swedish women in a prospective 20-
Patients with ductal carcinoma-in-situ (DCIS) are currently not prescribed adjuvant systemic treatment after surgery and radiotherapy. Prediction of DCIS patients who would benefit from radiotherapy is warranted. Statins have been suggested to exert radio-sensitizing effects. The target for cholesterol-lowering statins is HMG-CoA reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathwa
National guidelines are released regularly, and professionals are expected to adopt and implement them. However, studies dealing with mental health-care professionals' views about guidelines are sparse. The aim of the present study was to highlight mental health-care staff's views on the Swedish national guidelines for 'psychosocial interventions for schizophrenia or schizophrenia-type symptoms' a
The He-3 “crisis” has become a fact in the last decade and large scale neutron detectors based on He-3 technologies have become unaffordable. This new He-3 reality has resulted in a major effort worldwide to develop replacement neutron-detector technologies. Many of these technologies are in their infancy and need to be thoroughly tested before becoming mainstream, while others are approaching co
All three critical points of the evolutionary explanation proposed by Maestripieri et al. may not withstand close scrutiny. Instead, there should be an alternative explanation that has nothing to do with genetic continuity, but stresses the rewarding property of attractiveness that results mainly from sociocultural value assignment and sexual experience pursuit.
File-sharing has become synonym with the “digital economy” where large music conglomerates as well as certain artist voice strong concern over the impact on their bottom line. This research analyzes the music industry, which has been heavily impacted by a major technological shift i.e. the invention, and rollout, of the Internet. We look to the technological shift that has enabled the downloading
The SYT-SSX fusion gene has been implicated in the malignant tumor cell growth of synovial sarcoma, but the underlying molecular mechanisms are still poorly understood. Here we demonstrate that SYT-SSX is critical for the protein level of cyclin D1 in synovial sarcoma cells. Antisense oligonucleotides to SYT-SSX mRNA rapidly and drastically decreased cyclin D1 and subsequently inhibited cell growt
Objective: Opioids have long been prescribed for chronic pain conditions, including osteoarthritis (OA). However, there is little information about their temporal efficacy, or differences in efficacy and safety between opioids with strong versus weak/intermediate μ opioid receptor–binding affinity. To explore these research questions, we conducted a systematic review and meta-analyses of randomize
The HAVOSS (Handling Vulnerabilities in OSS) maturity model describes important processes for managing security vulnerabilities in OSS modules in developed products. So far, the model has not been evaluated in any real assessment process. Here we present a study where the model was evaluated by using it in assessments of processes for two product types in one organization. Each assessment was cond
The mechanisms underlying M. fortuitum-induced pathogenesis remains elusive. Using headkidney macrophages (HKM) from Clarias gariepinus, we report that TLR-2-mediated internalization of M. fortuitum is imperative to the induction of pathogenic effects. Inhibiting TLR-2 signalling alleviated HKM apoptosis, thereby favouring bacterial survival. Additionally, TLR-2-mediated cytosolic calcium (Ca2+)c
Huvudsyftet med denna rapport är att förutsäga antalet spelare i nå- gon instans av DICE: s spelplattformar, t.ex. Battlefield 3 för PC, 15 minuter i framtiden. Denna förutsägelse kan användas av företaget vid köp av molnservrar on-demand för att visa dem hur mycket de behöver köpa. Flera olika prognosmodeller undersöks och utvärderas på historisk data från 2011 till 2015. En annan fokuspunkt är hThe main goal of this thesis is to predict the number of players in some instance of DICE’s gaming platforms, e.g. Battlefield 3 for PC, 15 minutes in the future. This prediction may be used by the company when buying on-demand cloud servers to tell them how much they need to buy. Several different prediction models are examined and evaluated on historical data from 2011 to 2015. Another focus poi
Title: “We are actually doing this for real”: Organizational identity and identification when CSR is part of the business model Seminar date: 1st of June 2020 Course: BUSN49 Degree Project in Managing People, Knowledge and Change Authors: Misha Voss Gustavsson & Olof Skäremo Supervisor: Monika Müller Key words: CSR, sustainable business model, organizational identity & organizational
