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The SYT-SSX fusion gene has been implicated in the malignant tumor cell growth of synovial sarcoma, but the underlying molecular mechanisms are still poorly understood. Here we demonstrate that SYT-SSX is critical for the protein level of cyclin D1 in synovial sarcoma cells. Antisense oligonucleotides to SYT-SSX mRNA rapidly and drastically decreased cyclin D1 and subsequently inhibited cell growt
Patients with ductal carcinoma-in-situ (DCIS) are currently not prescribed adjuvant systemic treatment after surgery and radiotherapy. Prediction of DCIS patients who would benefit from radiotherapy is warranted. Statins have been suggested to exert radio-sensitizing effects. The target for cholesterol-lowering statins is HMG-CoA reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathwa
Objectives: To study signs of obstructive airway disease (OAD) in patients with primary Sjögren's syndrome (pSS) using the forced oscillation technique (FOT). Method: Thirty-seven female pSS patients (median age 64, range 38-77 years) without previous physician-diagnosed OAD, participating in a longitudinal follow-up study of pulmonary function, and 74 female population-based controls (median age
Objective: Opioids have long been prescribed for chronic pain conditions, including osteoarthritis (OA). However, there is little information about their temporal efficacy, or differences in efficacy and safety between opioids with strong versus weak/intermediate μ opioid receptor–binding affinity. To explore these research questions, we conducted a systematic review and meta-analyses of randomize
This thesis deals with older persons on the move and their access to cross-border healthcare in the European Union. The number of persons crossing borders within the EU has increased exponentially in recent decades. Free movement has been at the core of the European integration project from its early days. Although it was originally intended to apply only to those who were economically active, the
The mechanisms underlying M. fortuitum-induced pathogenesis remains elusive. Using headkidney macrophages (HKM) from Clarias gariepinus, we report that TLR-2-mediated internalization of M. fortuitum is imperative to the induction of pathogenic effects. Inhibiting TLR-2 signalling alleviated HKM apoptosis, thereby favouring bacterial survival. Additionally, TLR-2-mediated cytosolic calcium (Ca2+)c
Background. Sunlight exposure and fair skin are major determinants of human vitamin D production, but they are also risk factors for cutaneous malignant melanoma (MM). There is epidemiological evidence that all-cause mortality is related to low vitamin D levels. Methods. We assessed the avoidance of sun exposure as a risk factor for all-cause mortality for 29 518 Swedish women in a prospective 20-
Background: Health care providers in many countries have delivered interventions to improve physical activity levels among their patients. Thus far, less is known about the population's interest to increase their physical activity levels and their opinion about the health care provider's role in physical activity promotion. The aims of this paper were to investigate the self-reported physical acti
Title: “We are actually doing this for real”: Organizational identity and identification when CSR is part of the business model Seminar date: 1st of June 2020 Course: BUSN49 Degree Project in Managing People, Knowledge and Change Authors: Misha Voss Gustavsson & Olof Skäremo Supervisor: Monika Müller Key words: CSR, sustainable business model, organizational identity & organizational
Huvudsyftet med denna rapport är att förutsäga antalet spelare i nå- gon instans av DICE: s spelplattformar, t.ex. Battlefield 3 för PC, 15 minuter i framtiden. Denna förutsägelse kan användas av företaget vid köp av molnservrar on-demand för att visa dem hur mycket de behöver köpa. Flera olika prognosmodeller undersöks och utvärderas på historisk data från 2011 till 2015. En annan fokuspunkt är hThe main goal of this thesis is to predict the number of players in some instance of DICE’s gaming platforms, e.g. Battlefield 3 for PC, 15 minutes in the future. This prediction may be used by the company when buying on-demand cloud servers to tell them how much they need to buy. Several different prediction models are examined and evaluated on historical data from 2011 to 2015. Another focus poi
This dissertation deals with the effects of coherence and correlations on transport through nanostructures. Simulations are mainly performed using the second order von Neumann approach, a method capable of dealing with these effects in the presence of higher order tunneling. We see that such effects can result in various kinds of current suppression as well as efficient thermoelectric devices. Fu
In recent years there has been an intensive discussion about how Sweden should be organized in the future. At the turn of 2010/2011six Halland communes formed Region Halland. In this thesis the changes of the Swedish state space are studied through a theoretical approach which focuses on the spatial selectivity. By the concept of spatial selectivity the political-economic aspects of spatial chang
