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Gwadar port is a deep-sea port that lies at the southwestern coast of the Balochistan province. Since 2002, it has been given quite some attention; the government realized its potential of becoming a major hub port of the region, given its proximity to the Strait of Hormuz, a sea passage through which a fifth of the world’s oil transit occurs. MOUs have been signed and commitments made in excess o

Thesis purpose: The purpose is to enhance the understanding of the influence inclusion has on Generation Y consumers when utilised in fashion brands. By isolating two areas of interest namely marginalised gender and size, we aim to provide insight into their effects on the attitude and purchase intention. Methodology: A deductive approach and therefore a quantitative research design is chosen. T

Background: Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes. Results: In two cohorts of primary breast cancers, PKC alpha levels correlated to estrogen and progesterone receptor negativity, tumor grade, and proliferative activity, whereas PKC delta a

Protection against mucosally transmitted infections probably requires immunity at the site of pathogen entry(1), yet there are no mucosal adjuvant formulations licensed for human use. Polyethyleneimine (PEI) represents a family of organic polycations used as nucleic acid transfection reagents in vitro and DNA vaccine delivery vehicles in vivo(2,3). Here we show that diverse PEI forms have potent m

In osteoblasts, cyclooxygenase 2 (COX-2) is the major isozyme responsible for production of prostaglandins. Prostaglandins are local mediators of bone resorption and formation and are known to be involved in bone's adaptive response to fluid shear stress (FSS). We have previously described a model of trabecular bone loss in hindlimb-suspended mice and rats and demonstrated partial protection from

Bacterial binding was studied to determine whether thrombospondin-1 (TSP) acts as a ligand in attachment of coagulase-negative staphylococci (CNS). Twenty-five of 27 CNS strains bound soluble TSP. Staphylococcus epidermidis J9P bound 125I-labelled TSP in a dose-dependent manner. Scatchard plot analysis of the binding of TSP by strain J9P revealed two Kd values of 6.4x10-95muM and 2.9x10-85muM. The

Background: Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility. Methods: PKC isoforms were downregulated with siRNA or modulated with activato

Rural depopulation is a concern in many countries, and various policy initiatives have been taken to combat such trends. This article examines whether hidden potential for rural population growth can be found in Sweden. If such potential exists, it implies that the development prospects for many rural areas are not as unpromising as they may seem today. If not, rapid rural depopulation can be expe

Formulating and implementing agricultural policies are important for the development of the agricultural sector and the rural population. The process of policy making is a political bargain between politicians and citizens. The outcome of this process, the policies, cannot be expected to be Pareto efficient resource allocations since altruistic behaviour is not very likely. All participants in the

Våren 2000 enades Europeiska Rådet om att senast år 2010 ha förvandlat Europa till världens mest konkurrenskraftiga kunskapsbaserade ekonomi. Riktlinjerna samlades i den s.k. Lissabonstrategin. Genom att kritiskt granska dokument som producerats inom ramen för Kommissionens agenda i2010: "Ett informationssamhälle för tillväxt och konkurrens" vill jag synliggöra hur EU beskriver informat

The lytic polysaccharide monooxygenase (LPMO) enzymes boost polysaccharide depolymerization through oxidative chemistry, which has fueled the hope for more energy-efficient production of biofuel. We have recently proposed a mechanism for the oxidation of the polysaccharide substrate (E. D. Hedegård and U. Ryde, Chem. Sci., 2018, 9, 3866-3880). In this mechanism, intermediates with superoxide, oxyl

Objective. Non-neuronal acetylcholine (ACh) has been suggested to be a mediator for the development of various types of cancer. We analyzed a possible role for this molecule in carcinogenesis and/or progression of human colon cancer, in patient biopsies harvested from the colon during surgery. We addressed whether ACh synthesis (by choline acetyltransferase) and/or degradation (by ACh esterase), a

This paper presents findings from a longitudinal, experimental project investigating the effect of translation on the morphosyntactic accuracy of advanced Swedish (L1) learners of English (L2). The subjects were first-year students of English at a Swedish university. The curriculum was communicative and translation (Focus-on-Forms) was used judiciously. The research is couched in cognitive psycho

This paper concerns the proper definition of embeddings in purely category-theoretical terms. It is argued that plain category theory cannot capture what, in the general case, constitutes an embedding of one structure in another. We discuss three available solutions to this problem: variants of monics, concrete categories, and allegories. The first and last of these are found to be unable to solve

Cloud RAN (C-RAN) is a promising paradigm for the next generation radio access network infrastructure, which offers centralised and coordinated base-band signal processing in a cloud-based BBU pool. This requires extremely low latency responses to achieve real-time signal processing. In this paper, we analysed the challenges to introduce cloud native model for signal processing in C-RAN. We studie