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A scattering study of concentrated lens protein solutions and mixtures - Towards understanding the molecular origin of presbyopia

Healthy eye lenses are transparent and flexible, able to adapt shape in order to focus on far away and close-by objects. With age, however, this flexibility is lost, leading to a condition known as presbyopia. This vision disorder where close-by objects appear blurred commonly starts around the age of 40. The aim of this thesis is to elucidate the molecular origin of the gradual hardening of the c

Polyamine Pathway as Drug Target against Malaria

Popular Abstract in English An algae that has lost its ability to do photosynthesis over the last million years and started to feed on human blood causes about 600.000 death every year, a number equals about 8 times Lund’s present population. This evolved algae named Plasmod- ium falciparum causes Malaria, a tropical disease mainly affecting economically weak regions in Africa. Unlike bacteria or Malaria, caused by the protozoan parasite Plasmodium falciparum is responsible for about 600.000 death cases every year. Mainly affected are populations of subtropical countries in Africa and the largest groups of victims are children below the age of 5 years. The fast evolving drug resistances of Plasmodium against the the most pow- erful antimalarials threatens the successful containment of this

Lipid sponge phase nanostructures as carriers for enzymes

Nonlamellar lipid liquid crystalline phases have many potential applications, such as for drug delivery, protein encapsulation or crystallization. Lipid liquid crystalline sponge phase (L3) has so far not been very much considered in these applications, in spite of apparent advantages in terms of its flexibility and capacity of forming large aqueous pores able to encapsulate large bioactive molecu

Modification of Oxide Surfaces with Functional Organic Molecules, Nanoparticles, and Hetero-Oxide Layers

Popular Abstract in English It is hard to imagine present day’s lifestyle without the use of modern technologies as prevalent in sectors including bioscience & technology and the semiconductor & chemical industries. In technological advances of biosensors, catalysis, and microelectronics, the surface modification of materials (which includes modification of the wetting, structural, electriThe research work described in this thesis is concerned with the modification of oxide surfaces, as reflected by its title. The surfaces and their modification have been studied using a range of experimental surface characterization tools, in particular x-ray photoelectron spectroscopy (XPS), fluorescence microscopy, scanning electron microscopy, atomic force microscopy, and scanning tunneling mic