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Aims/hypothesisPPARGC1A encodes peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α), a central regulator of energy metabolism and mitochondrial function. A common polymorphism in PPARGC1A (rs8192678, C/T, Gly482Ser) has been associated with obesity and related metabolic disorders, but no published functional studies have investigated direct allele-specific effects in adipocyte bi

Complex diseases are caused by a combination of genetic, lifestyle, and environmental factors and comprise common noncommunicable diseases, including allergies, cardiovascular disease, and psychiatric and metabolic disorders. More than 25% of Europeans suffer from a complex disease, and together these diseases account for 70% of all deaths. The use of genomic, molecular, or imaging data to develop

Obesity and type 2 diabetes are causally related, yet there is considerable heterogeneity in the consequences of both conditions and the mechanisms of action are poorly defined. Here we show a genetic-driven approach defining two obesity profiles that convey highly concordant and discordant diabetogenic effects. We annotate and then compare association signals for these profiles across clinical an

B lymphocyte development is dependent on the interplay between the chromatin landscape and lineage-specific transcription factors. It has been suggested that B lineage commitment is associated with major changes in the nuclear chromatin environment, proposing a critical role for lineage-specific transcription factors in the formation of the epigenetic landscape. In this report, we have used chromo

Background: Although ranibizumab has been used for the treatment of wet age-related macular degeneration (AMD) since 2007, real-world studies still report undertreatment resulting in a less favorable visual outcome. In this study, two different time cohorts of patients treated with ranibizumab for wet AMD in routine care were analyzed to observe whether there was a change over time regarding visua

The host response to immunologically incompatible intrastriatal neural grafts was studied using immunohistochemical techniques. Dissociated ventral mesencephalic tissue from embryonic donors of either syngeneic, allogeneic or xenogeneic (mouse) origin was stereotaxically implanted into adult rats. The brains were analysed 4 days, 2 weeks or 6 weeks after grafting with antibodies against the follow

The Augustan poet Ovid (43 BC – AD 17/18) is mentioned by Seneca the elder for his oratorical skills as a school boy. If we are to believe Seneca, Ovid excelled to such a degree that he even surpassed his teachers. He took special interest in exercises concerning ethos, and is said to have transferred what he learned into his own verse. The influence from rhetorical training is indeed visible in O

Water and salt mass balances for the Dead Sea were modeled. Precipitation, evaporation, river discharges, ground water flows, input/output from potash companies and salt production, and brine discharge were included in the models. The mixing time in the Dead Sea was modeled using a single-layer (well-mixed) a two-layer (stratified) system. Using the single-layer approach the water level was predi

An ethopoeia is an imagined speech assigned to a certain character. As a rhetorical exercise it is known from the progymnasmata of Theon, Hermogenes, Aphthonius and Nicolaus as well as contemporary rhetorical theorists. The purpose of the exercise was to teach the student the appropriate use of ethos and pathos for the assigned character. The paper will present the function of the ethopoeia as a p

Fe(III) complexes with N-heterocyclic carbene (NHC) ligands belong to the rare examples of Earth-abundant transition metal complexes with long-lived luminescent charge-transfer excited states that enable applications as photosensitizers for charge separation reactions. We report three new hexa-NHC complexes of this class: [Fe(brphtmeimb)2]PF6(brphtmeimb = [(4-bromophenyl)tris(3-methylimidazol-2-yl

Genes encoding B lineage–restricted transcription factors are frequently mutated in B-lymphoid leukemias, suggesting a close link between normal and malignant B-cell development. One of these transcription factors is early B-cell factor 1 (EBF1), a protein of critical importance for lineage specification and survival of B-lymphoid progenitors. Here, we report that impaired EBF1 function in mouse B

This article is a response to Steven Enderlein on the translation of Rom 3:23 and its implications for the πίστις Χριστοῦ debate. While affirming Enderlein's suggestion that the verb ὑστερέω is better understood as “lack” rather than “fall short,” we argue against his conclusions (1) that this translation leads to a subjective genitive reading of πίστις Χριστοῦ in Rom 3:22, 26; and (2) that the ve

The "International Society for Heart and Lung Transplantation Guidelines for the Evaluation and Care of Cardiac Transplant Candidates-2024" updates and replaces the "Listing Criteria for Heart Transplantation: International Society for Heart and Lung Transplantation Guidelines for the Care of Cardiac Transplant Candidates-2006" and the "2016 International Society for Heart Lung Transplantation Lis