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The oscillations between glacial and interglacial climate conditions over the past three million years have been characterized by a transfer of immense amounts of water between two of its largest reservoirs on Earth - the ice sheets and the oceans. Since the latest of these oscillations, the Last Glacial Maximum (between about 30,000 and 19,000 years ago), similar to50 million cubic kilometres of
Short-hairpin RNA (shRNA)-mediated gene knockdown is a powerful tool for targeted gene silencing and an emerging novel therapeutic strategy. Recent publications, however, reported unexpected toxicity after utilizing viral-mediated shRNA knockdown in vivo. Thus, it is currently unclear whether shRNA-mediated knockdown strategy can be used as a safe and efficient tool for gene silencing. In this stu
The radiation and total efficiencies, the amount of gas radiation from vapour and carbon dioxide and contribution from convective heat transfer for different operating conditions have been measured and modelled in an industrial gas heated IR dryer. Instrumentation to facilitate the measurement of the spectral distribution of the radiation heat fluxes in industrial infrared equipment has been devel
In 2005 a Greek and American interdisciplinary team investigated two shipwrecks off the coast of Chios dating to the 4th-century b.c. and the 2nd/1st century. The project pioneered archaeological methods of precision acoustic, digital image, and chemical survey using an autonomous underwater vehicle (AUV) and in-situ sensors, increasing the speed of data acquisition while decreasing costs. The AUV
Construction of synthetic basis functions (SBFs) for analyzing the radiation problems of antenna arrays is discussed. The SBFs of a block are generated from two separate solution spaces, with one space to account for the effect of the feeding voltages, and the other space to account for the responses of the block to incident electromagnetic fields from its environment. Singular value decomposition
The purpose of this paper is to describe strategic improvisation, a contemporary concept and approach based on the creative arts and organizational crisis theory, as a valuable approach for communication professionals. Strategic improvisation combines the need for planning and structure with creative action, and is a normative idea of how to work in an efficient way.Design/methodology/approach: Th
Hybridization is increasingly recognized as a potent evolutionary force. Although additive genetic variation and novel combinations of parental genes theoretically increase the potential for hybrid species to adapt, few empirical studies have investigated the adaptive potential within a hybrid species. Here, we address whether genomic contingencies, adaptation to climate, or diet best explain dive
On- and off-line heterogeneous non-competitive flow immunoassays for the determination of Interleukin-10 are described. The sample containing IL-10 is mixed, either on-line in a reaction coil or off-line in a test tube, with fluorescent labelled anti-IL-10 antibodies to form an antibody-antigen complex. The labelled unbound antibodies are trapped on an immobilized IL-10 column whereas the IL-10-an
During the last few years, a more liberal use of premedication in children scheduled for Ürinary tract examinations was noted. In this retrospective study, the influence of the institution of psychological means for preparation as supplement or alternative to premedication on the incidence of cases receiving premedication was investigated. During the period from 1978 to 1982, this was followed in
BACKGROUND: There is a lack of published, validated questionnaires for evaluating psychosocial morbidity in patients with breast hypertrophy undergoing breast reduction surgery.AIM: To validate the breast evaluation questionnaire (BEQ), originally developed for the assessment of breast augmentation patients, for the assessment of psychosocial morbidity in patients with breast hypertrophy undergoin
The article engages in a critical discussion of the related variety/regional branching argument and foregrounds a more differentiated perspective on regional industrial path development. It contributes by (i) sharpening the definition of key concepts, namely specialisation and diversity, related and unrelated variety; (ii) discussing their relevance in local and nonlocal spaces; (iii) scrutinizing
Abstract in UndeterminedIn this paper we describe and reflect upon a novel methodology using attention cards to facilitate communication, concentration and creativity in a user requirement workshop with seniors. Previous research indicates that seniors tend to lose focus and start cross talking during workshops, which results in broad and shallow findings. However, our findings indicate that the u
BACKGROUND/AIM: High morbidity and mortality rates, chronic course of disease and numerous clinical complications, make diabetes mellitus (DM) type 2 bear significant financial burden for healthcare system of Serbia. The aim of this study was to compare true disease-related expenses measured in the random sample of patients originating from the Central Serbia in 2007 and national estimate of total
This article examines how the ‘essentiality’ requirement can limit the exercise of the EU’s criminal law competence under Article 83(2) TFEU. Building on criminological research, and contextual and principled considerations, it argues for an evidence-based approach to the ‘essentiality’ criterion. It sustains that the Union legislator must show by empirical proof that criminal laws are more ‘effec
A highly sensitive flow-injection capacitive immunosensor was developed for detection of the mycotoxin zearalenone (ZEN). Different strategies for immobilization of an anti-ZEN antibody on the surface of a gold electrode, i.e. polytyramine or self-assembled monolayers (SAMs) of 3-mercaptopropionic acid (3-MPA) and lipoic acid (LA), were used and their performances were compared. The LA- and 3-MPA-
