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Therapeutic peptides are a fast-increasing segment in the pharmaceutical industry, and GLP-1 analogues stood for two out of the three most sold drugs last year, 2025. The most common production method of peptides is based on Merrifield’s discovery of solid-phase peptide synthesis (SPPS), which uses large volumes of hazardous chemicals like N,N-dimethylformamide (DMF), piperidine, and trifluoraceti
Electricity demand in southern Sweden is expected to increase significantly in the coming decades. More electric cars, cleaner industries, and the phase-out of fossil fuels will require much larger amounts of electricity than today. At the same time, Skåne currently produces only part of the electricity it consumes and depends heavily on electricity imports from other regions and neighbouring coun
Various devices rely on invasive biometric identifiers, such as voice and facial recognition, raising privacy concerns. Acoustic handclap control presents a privacy-preserving alternative for interaction with computers, as it does not capture speech or visual data. An analysis of the original implementation suggested that existing classifiers were influenced by environmental bias. With the objecti
How does new technology impact labor market outcomes? We address this question by examining the adoption of electricity in Sweden during the early 20th century. Leveraging detailed individual-level data that covers the entire labor market and exogenous variation in electricity access driven by proximity to hydro-power plants, we estimate the impact of electrification on individual labor market out
This article introduces the pattern theory of immersivity (PTI), a practice-led theoretical framework stemming from the hypothesis that a reorientation of the understanding of immersive art is needed, away from technological sophistication or sensory excess and toward the psychological mechanisms underlying imaginative engagement, regardless of artform or combination of media. The theory posits th
A new development within the high spin Nilsson-Strutinsky formalism presented and applied to certain sd-shell nuclei. The previous method of calculating potential-energy surfaces as a function of angular momentum using interpolated spin values is not satisfactory when studying the individual bands for these light nuclei. In the present research, manyparticle many-hole excitations are considered in
Marketing is an important function and practice in everyday business. It involves getting potential customers interested in a product or service through value-oriented arguments. In this way, marketing plays a pivotal role in driving the consumption of goods and services. Given the increasing consumption of goods and services, decreasing product lifetimes, and increasing levels of waste in all pro
The field of biomedicine is constantly investing significant research efforts in order to gain a more in-depth understanding of the mechanisms that govern the function of body compartments and to develop creative solutions for the repair and regeneration of damaged tissues. The main overall goal is to develop relatively simple systems that are able to mimic naturally occurring constructs and can t
Researchers selecting probands for molecular genetic studies confront a range of sampling issues with modest empirical guidance. In this paper, using cases of major depression (MD), anxiety disorders (AD) alcohol use disorder (AUD), drug use disorder (DUD), bipolar disorder (BD) and schizophrenia (SZ) from a large population cohort of all native Swedes born 1940–2003, we examine the implications o
LONG-TERM depletion of ozone has been observed since the early 1980s in the Antarctic polar vortex, and more recently at mid-latitudes in both hemispheres, with most of the ozone loss occurring in the lower stratosphere1. Insufficient measurements of ozone exist, however, to determine decadal trends in ozone concentration in the Arctic winter. Several studies of ozone concentrations in the Arctic
Popular Abstract in Swedish Avsaltning av havsvatten utgör en viktig källa för vattenförsörjning till befolkningen som bor vid Persiska viken, Medelhavet och Röda havet. De tre regionerna utgör ca 11,8 % av världens landyta och hade omkring 9 % av världens befolkning under 1950 och 2008, samt lika mycket enligt prognos för år 2050. Dessa områden är hemvist för 62 %, 58% och 60% av världens avsaltnIn this M.Sc. Thesis of a comparison for sewerage system of the three main municipalities of Turkish Republic of Northern Cyprus (T R N C) has been studied and discussed. The study covers the future population calculations for three municipalities, Nicosia, Famagusta and Kyrenia, by means of Turkish and European standards. The comparisons for sewerage system of the three municipalities are compare
This commentary discusses the role of increasingly artificial intelligence-infused big tech platforms in facilitating and normalising high-emission lifestyles and consumption practices. It introduces the notion of algorithmically facilitated emissions to initiate a shift from a logic of ‘climate collapse by design’ to a logic of ‘emissions reduction by design’. Reducing consumption-based emissions
The maximum drawdown of a stochastic process is the largest peak-to-troughdecline observed over a given horizon [0, T]. Using arguments from extremevalue theory, we derive the limiting distribution of the maximum drawdown fora Brownian motion with positive drift as T → ∞. We show that, after suitablecentering and scaling, the maximum drawdown converges in distribution to theGumbel law.
OBJECTIVES: The Sepsis-3 definition states the clinical criteria for sepsis but lacks clear definitions of the underlying infection. To address the lack of applicable definitions of infection for sepsis research, we propose new criteria, termed the Linder-Mellhammar criteria of infection (LMCI). The aim of this study was to validate these new infection criteria.DESIGN: A multicenter cohort study o
The unification of quantum mechanics and general relativity has long been elusive. Only recently have empirical predictions of various possible theories of quantum gravity been put to test, where a clear signal of quantum properties of gravity is still missing. The dawn of multi-messenger high-energy astrophysics has been tremendously beneficial, as it allows us to study particles with much higher
The dissertation Deductionis coloniarum rationes & causae, submitted at Uppsala University in 1668 under the presidency of Johannes Schefferus, appears to be the firstcontribution to the Swedish discourse on the subject of colonisation and colonialism. In this paper, a translation of the text is presented with a commentary and a list of sources. In an introduction to the translation, which dis
A central challenge in linguistics pertains to understanding how the polished, static form of a written text emerges from the messy, moment-by-moment decisions of the writer. While the structures of finished texts have been extensively theorized, and the real-time cognitive processes of writing have been widely studied, the relationship between these real-time processes and the functional linguist
