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Recent animal studies have shown that D-glucose is a potential biodegradable MRI contrast agent for imaging glucose uptake in tumors. Here, we show the first translation of that use of D-glucose to human studies. Chemical exchange saturation transfer (CEST) MRI at a single frequency offset optimized for detection of hydroxyl protons in D-glucose (glucoCEST) was used to image dynamic signal changes

This article contains an overview of the current proposals of converging IP-networks with PSTN. We describe Parlay and Open Service Access( OSA), two of the most promising architecture.

Purpose: The Extremely Preterm Infants in Sweden Study (EXPRESS) followed a national cohort of extremely preterm born (EPT, i.e. <27 weeks) children until 12 years of age. This study aimed to investigate the longitudinal development of visual acuity (VA) in children born EPT, explore the predictive value of early visual assessments, and evaluate risk factors for visual impairment at the age of 12

Den boreala skogen, mer känd som taigan, breder ut sig på de nordliga delarna av norra halvklotet innan den trädlösa tundran tar över. I detta enorma skogsområde som sträcker sig genom Skandinavien, Ryssland och Nordamerika är störningar i form av bränder, insektsangrepp och stormar vanliga och en naturlig del av ekosystemet. Dessa störningar påverkar skogens kolbalans genom deras inverkan på bådeNatural disturbances such as fires, insect outbreaks and windthrows are able to influence the balance between the ecosystem gain and loss of carbon in the boreal forest. This effect of natural disturbances on the ecosystem carbon balance has been proposed as one of the reasons why the CO2 concentration in the atmosphere varies between years. At present the boreal forest as a whole act to mitigate

For modern high-efficiency gas turbines, film cooling is an essential method to protect the turbine blade from the hot gas, and the issue about how to improve the film cooling performance has attracted much attention. This study presents a new design concept used for film cooling in gas turbine to improve the overall cooling effectiveness and better decrease the metal temperature of the blade at t

In butterflies, male reproductive success is highly related to the quality and the size of the spermatophore transferred to the female. The spermatophore is a capsule produced by the male during copulation, which in many species contains sperm in addition to a nuptial gift, and which is digested by the female after copulation. The nuptial gift may contribute to egg production and offspring quality

This paper focuses on the specific problems in the labour and social security legislation as it relates to crowdworkers in the digitalizes new economy, analyzing their place in labour market, and especially in the collective agreements which are the standard means of regulating working conditions in the Nordic model. Sweden has a binary system where a performing party is as either an employee or s

Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with advanced cancers1. Current predictive biomarkers for therapy response include high levels of intratumour immunological activity, a high tumour mutational burden and specific characteristics of the gut microbiota2,3. Although the role of T c

An experimental study on the duration of load effects in a glued shear plate dowel joint was conducted. The joint design features a single large diameter dowel for load transfers between members, via external steel plates, which are bonded to the timber with a low stiffness bond line. Due to the low bond line stiffness, the timber element is subjected to a close to uniform shear stress distributio

1. Hepatectomized rats were injected intravenously with doubly labelled ([14C]linoleic acid and [3H]palmitic acid) thoracic duct lymphs from rats fed cream, triolein or corn oil. The disappearance of the radioactive fatty acids of different molecular triacylglycerol species and of phospholipids from plasma was studied.2. 73–93% of the injected triacylglycerols had been cleared from plasma within 1

Background: While housing and neighborhood features have the potential to impact opportunities for active aging, there is a lack of knowledge related to how older people reason regarding their housing situation and how housing and fulfillment of relocation are associated with active and healthy aging. Objective: The objectives of Prospective RELOC-AGE are to study housing choices and relocation an

BACKGROUND: The Chronic Kidney Disease in Children Study (CKiD) equation for children and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for adults are recommended serum creatinine (SCr)-based calculations for estimating glomerular filtration rate (GFR). However, these equations, as well as their combination, have limitations, notably the problem of implausible changes in

In liquid-liquid chromatography (LLC), components of a mixture are separated due to their different distribution between the phases of a biphasic liquid system composed of two or more solvents. In this work, for the first time, we combine a chromatography model with a liquid-liquid equilibria thermodynamic model to simulate the propagation of the solute and the solvents along the LLC column. The m

The amyloid precursor protein intracellular domain (AICD), a cleavage product of amyloid precursor protein implicated in Alzheimer disease and amyloid lateral sclerosis, is a functionally important but structurally elusive intrinsically disordered protein. In this study, we investigate the conformational ensemble of a 35-residue AICD segment encompassing the conserved YENPTY motif using molecular

In this research, a straightforward and effective preconcentration technique was developed by integrating three-phase hollow fiber liquid-phase microextraction (HF-LPME) with high-performance liquid chromatography equipped with a photodiode array detector and mass spectrometry (HPLC-DAD/MS) for the simultaneous extraction and quantification of trace levels of tamoxifen (Tam) and clomiphene (Clom)

This study investigates the surface transformations of nickel foam (NF) electrodes induced by Fe and Co cation incorporation from the electrolyte following activation in the oxygen evolution reaction (OER), using both ex situ time-of-flight secondary ion mass spectrometry (TOF-SIMS) and in situ near-ambient pressure X-ray photoelectron spectroscopy (NAP-XPS). Electrochemical measurements demonstra

Multi-wavelength thermo-optical analysis (MW-TOA) and Raman spectroscopy are commonly used methods to study soot sampled on filters, in terms of carbon content, nanostructure, and absorption properties. In this work, these techniques were combined to study how these characteristic properties of soot change in premixed flames, 1) at various flame heights during soot maturation and 2) as a result of

Using megahertz x-ray free electron laser imaging with x-ray pulses of ~25 femtoseconds and a machine-learning strategy, we have conducted comprehensive in situ imaging studies on the dynamics of cavitation bubble clouds in ultrasound fields at the SPB/SFX beamline of the European XFEL. The research unambiguously revealed the quasi-simultaneous implosion of multiple bubbles and simultaneous collap