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Cerebral uptake of morphine in the pig calculated from arterio-venous plasma concentration gradients: an alternative to tissue microdialysis

The aim of this study was to characterize the reversible cerebral uptake of morphine in the pig by measuring the changing arterio-venous plasma concentration gradient over the brain. Seven pigs were anaesthetized by continuous infusions of ketamine and pancuronium and ventilated with oxygen in nitrous oxide. During and after 5-min intravenous infusions of morphine hydrochloride, blood samples were

Center of volume and total heart volume variation in healthy subjects and patients before and after coronary bypass surgery.

BACKGROUND: Total heart volume variation (THVV) and center of volume variation (COVV) likely affects the efficiency of cardiac pumping, but no study has determined COVV of the heart throughout the cardiac cycle or the effect of surgery on THVV in adults. Therefore, the purposes of this study were to determine COVV in healthy adults and patients with cardiac failure due to ischemic heart disease (I

Architecture of the global land acquisition system: applying the tools of network science to identify key vulnerabilities

Global land acquisitions, often dubbed 'land grabbing' are increasingly becoming drivers of land change. We use the tools of network science to describe the connectivity of the global acquisition system. We find that 126 countries participate in this form of global land trade. Importers are concentrated in the Global North, the emerging economies of Asia, and the Middle East, while exporters are c

Radiative lifetimes and transition probabilities in Rh I

Radiative lifetimes of 17 high-lying excited states in Rh I aremeasured using the time-resolved laser-induced fluorescence method. Out of these lifetimes, 13 are new and the remaining four confirm previous measurements. Furthermore, we report the first theoretical investigation of Rh I, where the radiative decay properties of all experimentally known levels below 47 000 cm(-1) are calculated using

National Incidence and Prevalence of TSH-Secreting Pituitary Adenomas in Sweden.

Context:TSH-secreting pituitary adenomas (TSHomas) are rare. Epidemiological data are scant and there are no reports on national incidence.Objective:The objective of the study was to estimate the national Swedish incidence and prevalence of TSHomas.Design:This was an observational study.Setting:The study was conducted at tertiary referral centers.Patients:The Swedish Pituitary Registry and World H

Parkinson's Disease Case Ascertainment in the EPIC Cohort: The NeuroEPIC4PD Study

Background/Aims: Large epidemiological prospective studies represent an important opportunity for investigating risk factors for rare diseases such as Parkinson's disease (PD). Here we describe the procedures we used for ascertaining PD cases in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: The following three-phase procedure was used: (1) elaboration of a

PACS for radiology conferences--improvement of application software

The introduction of PACS in a radiology department means that most functions that are available in the film-based system must be included. One important function is the radiology conference. The handling and application programs of digital workstations are normally not developed for demonstrations of many images in a limited time. This paper describes a workstation with specially designed software

System Identification using LQG-Balanced Model Reduction,

System identification of linear multivariable dy-namic models based on discrete-time data can be performed using a algorithm combining linear regression and LQG-balanced model reduction. The approach is applicable also to unstable system dynamics and it provides balanced models for optimal linear prediction and control.

Anatomy and biomechanics of the back muscles in the lumbar spine with reference to biomechanical modeling

Study Design. This article describes the development of a musculoskeletal model of the human lumbar spine with focus on back muscles. It includes data from literature in a structured form. Objective. To review the anatomy and biomechanics of the back muscles related to the lumbar spine with relevance for biomechanical modeling. Summary of Background Data. To reduce complexity, muscle units have be

Influence of lifestyle behaviours on bone mineral density among young healthy women: A two-year study. A Tentative Salutary Model.

Popular Abstract in Swedish Skeletthälsa och livsstilsbeteenden hos unga kvinnor I Sverige kommer ungefär 50 % av alla kvinnor att drabbas av en fraktur någon gång under sitt liv. Ett starkt skelett med hög mängd benmassa är det som främst bidrar till att förebygga benskörhetsfrakturer. Kvinnor har efter ungdomsåren mindre mängd benmassa än män och mängden benmassa minskar hos kvinnor snabbare i The overall aim of this prospective observational study with a salutogenic approach was to investigate bone mineral density (BMD) and BMD changes in the heel bone, in a group of healthy women, in relation to physiological factors and lifestyle behaviours over a two-year period as well as investigating the women’s view of their lifestyle behaviours. Data were collected in 1999 (T1) and 2001 (T2). H

Time Delay Estimation for TDOA Self-Calibration using Truncated Nuclear Norm Regularization

Measurements with unknown time delays are common in different applications such as microphone array, radio antenna array calibration, where the sources (e.g. sounds) are transmitted in unknown time instants. In this paper, we present a method for estimating unknown time delays from Time-Difference-of-Arrival (TDOA) measurements. We propose a novel rank constraint on a matrix depending on the measu

Fluorescence lidar multispectral imaging for historical monuments, the Lateran Baptistery interdisciplinary project

Introduction For the future conservation, restoration and daily maintenance the need for developing non-destructive and in-situ investigations is vital. At Lund University in Sweden an interdisciplinary research project is being held aiming at, with the help of a mobile system of remote fluorescence lidar, survey and study the facades of historic monuments, and to develop the method and its applic

Fast and selective analytical procedures for determination of persistent organic pollutants in food and feed using recent extraction techniques

This chapter describes the utilization of recent extraction techniques such as supercritical fluid extraction, pressurized liquid extraction and microwave-assisted extraction for the determination of persistent organic pollutants in food and feed samples. These techniques have been developed because the extraction step can severely limit the entire analytical procedure. Several food crises, for ex

Hip fracture - Mortality and residual lifetime risk of fractures

Popular Abstract in Swedish Osteoporos (benskörhet) innebär att såväl bentätheten som skelettets hållfasthet minskar, vilket leder till ökad risk att få frakturer (benbrott). Osteoporos är en folksjukdom, där frakturerna medför stora kostnader såväl för individen som för samhället. De frakturer som räknas som osteoporosfrakturer är i första hand de som drabbar höft, bäcken, axel, handled och kota.Hip fracture is the most severe clinical manifestation of bone fragility. Hip fracture predominantly affects an already frail population and is associated with multi-cause morbidity and high mortality. Improved knowledge of long-term outcome is essential in order to improve future care and prevention of both fracture and its complications. In this thesis, all hip fracture patients during 1984-198

Experimental methods of determining the activity depth distribution of implanted 210Pb in glass.

Glass is often used in radon surveys to estimate retrospective radon concentrations, as radon progenies are embedded in the upper surface layer. Experimental methods based on etching to determine the depth distribution of recoil-implanted 210Po in glass from radon decay in air is presented. By carefully controlling chemical concentrations and exposure time during which the glass is etched, stepwis

Factors That Affect Disease Progression After First Attack of Acute Pancreatitis

BACKGROUND & AIMS: Little is known about recurrence of pancreatitis after an initial episode, and little is known about how the disease progresses or what factors affect progression. We performed a population-based study of patients with acute pancreatitis (AP) to determine their outcomes and associated factors. METHODS: We performed a retrospective study of patients with first-time AP from 20

Characterizing nanoparticles in complex biological media and physiological fluids with depolarized dynamic light scattering

Light scattering is one of the few techniques available to adequately characterize suspended nanoparticles (NPs) in real time and in situ. However, when it comes to NPs in multicomponent and optically complex aqueous matrices - such as biological media and physiological fluids - light scattering suffers from lack of selectivity, as distinguishing the relevant optical signals from the irrelevant on

Carrier dynamics in InP nanopillar arrays fabricated by low-damage etching

We present a comprehensive characterization of the optical quality of InP nanopillars (NPs) fabricated by a top down approach using micro-photoluminescence (mu-PL), time-resolved PL, and cathodoluminescence (CL). A lattice matched InGaAs layer provided beneath the 1 mu m tall NPs functions as a "detector" in CL for monitoring carrier diffusion in InP NP. Carrier feeding to the InGaAs layer indicat