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The morphology and function of the arteries can be directly measured using different established methods. This prospective cohort study aimed to translate 2 of these, aortic pulse wave velocity (aPWV) and carotid intima–media thickness (cIMT), into a combined Vascular Aging Index (VAI) and then evaluate the predictive power of aPWV, cIMT, and VAI. Patients (n = 2718) were included from the cardiov

The present paper investigates the ongoing validity of the notion of subordination as selection criteria to allocate the labour protections in the contemporary economic framework. The gig economy is deeply affecting the way of working, transforming the employee in a service provider. This phenomenon is partially due to the progressive shift from a firm-based production model towards a market trans

Background: This prospective multicenter registry used intravascular ultrasound (IVUS) in patients with definite stent thrombosis (ST) to compare rates of incomplete stent apposition (ISA), stent fracture and stent expansion in patients treated with drug-eluting (DES) versus bare metal (BMS) stents. ST is a rare, but potential life threatening event after coronary stent implantation. The etiology

The effect of moderate hypoglycaemia (venous blood glucose 2.0 +/- 0.2 mmol/l; mean +/- SD) on regional cerebral blood flow and cerebral volume was studied in a group of ten right-handed patients with Type 1 (insulin-dependent) diabetes mellitus (age 26.0 +/- 2.4 years, duration 18.4 +/- 3.8 years) using an intravenous Xenon 133 single photon emission computed tomography technique. After 10 min of

The efficacy and safety of an advanced category recombinant antihaemophilic factor produced by a plasma- and albumin-free method (rAHF-PFM) was studied in 111 previously treated subjects with haemophilia A. The study comprised a randomized, double-blinded, crossover pharmacokinetic comparison of rAHF-PFM and RECOMBINATE rAHF (R-FVIII); prophylaxis (three to four times per week with 25-40 IU kg(-1)

Background Response to disease modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis (RA) is often heterogeneous. We aimed to identify types of disease activity trajectories following the initiation of a new biologic DMARD (bDMARD). Methods Pooled analysis of nine national registries of patients with diagnosis of RA, who initiated Abatacept and had at least two measures of disease activit

The Value of a Statistical Life (VSL) is a widely used measure of the value of mortality risk reduction. Since VSL should reflect preferences and attitudes to risk, there are reasons to believe that it varies depending on the type of risk involved. It has been argued that cancer should be considered a “dread disease”, which supports the use of a “cancer premium”. The objective of this study is to

Startups use prototyping to develop and validate their products and business models. For startups, it is important to have a good knowledge of relevant adoption factors, to make decisions regarding which prototyping technology to adopt. In this article, we identify such factors based on our practical experiences of startups in various industries. We define a research framework, describe challenges

According to religious fictionalism, a non-believer can participate in religious life by playing a game of make-believe. Considering how games of make-believe build on imagination and pretence, I argue that religious fictionalism requires the non-believing participant to engage in role-playing. Turning to the literature on role-playing games, I demonstrate how religious fictionalism conforms to a

Introduction: We aimed to assess cognitive function in women with preeclampsia stratified by severity, before and after onset of disease. Material and methods: Prospective study performed at a referral hospital in Cape Town, South Africa. Pregnant women between 20 and 42 weeks of gestation with eclampsia, pulmonary edema and preeclampsia without severe features, and a normotensive pregnancy were a

In 1822 the Parliament of the United Kingdom passed The Cruel Treatment of Cattle Act, which today is considered to be an important forerunner to modern animal protection and anti-cruelty legislation. However, the new Enlightenment attitudes to animals stemmed from an overly anthropocentric perception of the natural world and the place of the human animal in it. At the heart of the movement agains

Different strategies have been used to stimulate a return to work (RTW) among individuals suffering from long-term ailments. In Sweden a new law on "resting disability pension" permits disability pensioners to go back to work without jeopardising their benefits. In this study different variables related to RTW during 2000 by means of this legislation were identified among disability pensioners witDifferent strategies have been used to stimulate a return to work (RTW) among individuals suffering from long-term ailments. In Sweden a new law on "resting disability pension" permits disability pensioners to go back to work without jeopardising their benefits. In this study different variables related to RTW during 2000 by means of this legislation were identified among disability pensioners wit

Silene diclinis is a dioecious perennial herb, restricted to a small area of the SE Spanish province of Valencia. Polyacrylamide gel electrophoresis and morphometric analysis were carried out on cultivated material derived from seed collected from the main population of S. diclinis at Játiva. Only two out of 26 inferred enzyme loci showed substantial variation. There was some indication of populat

Ceramic biomaterials are promising alternatives to bone autografts. However, limited bioactivity affects their performance. Therefore, bioactive molecules and cells are often added to enhance their performance. Exosomes have emerged as cell-secreted vesicles, delivering proteins, lipids, and nucleic acids in a paracrine/endocrine fashion. We studied two complementary aspects required for exosome a

Bakgrund Teknikutvecklingen inom hälso- och sjukvårdsområdet möjliggör ständigt nya och mer avancerade sätt att distansmonitorera och vårda patienter digitalt. Digitaliseringen inom hälso- och sjukvårdsområdet i form av till exempel hälsoapplikationer gör det möjligt för patienter och personal att ha kontakt och kommunicera digitalt med varandra (WHO, 2011). itACiH är ett digitalt system där patie

BackgroundThe Dyspnoea-12 (D12) and Multidimensional dyspnea profile (MDP) are commonly used instruments for assessing multiple dimensions of breathlessness but have not been validated in older people in the population. The aim of this study was to validate the D12 and MDP in 73-years old men in terms of the instruments’ underlying factor structures, internal consistency, and validity.MethodsA pos