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In diploid populations of size N, there will be 2 Nmu mutations per nucleotide (nt) site (or per locus) per generation (mu stands for mutation rate). If either the population or the coding genome double in size, one expects 4 Nmu mutations. What is important is not the population size per se but the number of genes (coding sites), the two being often interconverted. Here we compared the total phys
Yesterday’s sole hardware product is becoming more and more rare. Today, the original products are increasingly surrounded by value adding services, software or control systems, all bundled together to a “total offer”. Christopher (1998) states that it is the totality of the offer which delivers customer value, and that adding value through differentiation and/or service is a powerful means of ach
This dissertation is about the introduction of school television in Sweden during the 1960?s. It focuses partly on formal and institutional attitudes and values, as in the educational system, and it is partly an investigation of the actual programmes made. The introduction and forming of school television is seen as a consequence due to many factors. It was the time of a growing welfare society wh
Anticipatory and predictive models are becoming very important features of robot systems. This thesis investigates some aspects of predictive modeling. Is prediction always a good thing? How important is it to anticipate what will happen in the future? Is it better to anticipate far into the future or to focus on the next few seconds? What are the requirements for predictive models? Predictive mod
A new method to determine quasi diabatic (QD) CASSCF states is presented. The adiabatic states are subjected to a unitary transformation resulting from diagonalization of a state-selection operator. The latter is constructed from the overlap of the adiabatic states with a suitable set of reference states. The multi-state (MS) CASPT2 method is used to account for the dynamical correlation effects i
The kinetics of structure change when dispersions of two different types of lipid-based liquid-crystalline phases, one lamellar and one reversed, are mixed has been investigated using synchrotron small-angle X-ray diffraction and ellipsometry. The systems studied were (i) cubic-phase nanoparticles (CPNPs) based on glycerol monooleate (GMO) stabilized with a nonionic block copolymer, Pluronic F-127
Sedan 1970-talet har det förts en aktiv diskussion om modernisering av språket som används av myndigheter och andra offentliga organ. För domstolarnas del var det den så kallade Förtroendeutredningen, vars betänkande presenterades år 2008, som blev startskottet för arbetet med att se över den språkliga utformningen av domar och beslut. Detta klarspråksarbete är numera ett naturligt inslag i domstoSince the 1970s there has been an ongoing public discussion in Sweden centered around efforts to modernize the language of the public sector. In 2008 an official report about communication between courts of law and citizens highlighted the necessity of improving the language of judgements and decisions, sparking further discussions and action. Since then, the courts have been actively working to p
Very-low-field MRI (<100 mT) holds promise for Point-of-Care brain imaging applications, including stroke and multiple sclerosis, with T1 mapping emerging as a key biomarker for brain development and pathology. However, current low-field T1 mapping protocols suffer from long acquisition times and limited multi-site repeatability. This study aimed to improve T1 mapping at 64 mT using a clinically f
This article examines the portrayal of bodily boundaries in the videogame series The Last of Us. Drawing on theories of media ecology and posthumanism (most notably Deer’s notion of radical animism, Haraway’s theories of the cyborg, and Fuller’s account of media assemblages), three aspects of this portrayal are described: first, the game’s narrativization of bodily violence through an amalgamation
Spectral information from induced polarisation (IP) measurements can be used for several applications as the characterisation of the lithology, the estimation of hydraulic parameters, the localization of contaminated areas and many more.So far, the spectral content has been mainly determined in frequency domain (FD). Due to significant instrumental developments and advanced data processing and inv
Background: The aim is to identify trajectories of precarious employment (PE) over time in Sweden to examine associations of these with the subsequent risk of myocardial infarction (MI) and stroke. Methods: This is a nation-wide register-based cohort study of 1,583,957 individuals aged 40 to 61 years old residing in Sweden between 2003-2007. Trajectories of PE as a multidimensional construct and s
BACKGROUND: The isolation of cell-free DNA (cfDNA) from the bloodstream can be used to detect and analyze somatic alterations in circulating tumor DNA (ctDNA), and multiple cfDNA-targeted sequencing panels are now commercially available for Food and Drug Administration (FDA)-approved biomarker indications to guide treatment. More recently, cfDNA fragmentation patterns have emerged as a tool to inf
BackgroundSuicide is a leading cause of premature mortality worldwide, but the impact of system-level mental health resources remains unclear despite the central role of psychiatric inpatient care and declining bed capacity. Prior research has yielded inconsistent findings with limited control for confounding. We aimed to estimate the effect of psychiatric inpatient bed availability on suicide mor
The aims of the study were to verify the longterm effect of time on viral clearance in hepatitis C virus (HCV) patients and to find out factors possibly associated with disease progression. A total of 1641 patients recruited from eight European centres in 1996-1.997 were re-analysed 5-7 years after inclusion. The occurrence of decompensated cirrhosis, hepatocellular carcinoma (HCC) and liver trans
This paper explores an innovation case within a “smart” Swedish mid-sized city that works extensively with digitalization.Over a long period in time, city populations and city tourism have increased, while more urgentchallenges connected to sustainability have emerged along with health-related problems. In parallel the already established and ongoing digitalization of society was fortified in the
In a recent paper we presented a procedure for optimal analyticalcontrol of several deformable mirrors based on only the measured guidestar wavefronts. The expected performance was evaluated for variousguide star configurations using up to three deformable mirrors. Forsimplicity the guide stars were assumed to be infinitely distant. Inthis paper we address the effect of using laser guide stars in
How is it that a group that self-identifies as “religious” and is associated with one of the most dramatic events in the United States during the 1980s could receive almost no attention from religious studies scholars? Furthermore, how is it that the court case in which said group was determined to not qualify as a “religion” has been discussed and challenged by legal scholars while being virtuall
Cognitive control is a skill used to control one’s own behaviour to reach a goal. We compared this skill across archosaurs by using the distraction task on American alligators, emus, chickens, and common ravens. We investigated whether the animals would still find a food reward hidden behind one of two identical opaque barriers after picking up a food distraction. Results show that all species can
PURPOSE: The phase III, open-label, prospective, multicenter, randomized Ewing 2008R1 trial (EudraCT2008-003658-13) was conducted in 12 countries to evaluate the effect of zoledronic acid (ZOL) maintenance therapy compared with no add-on regarding event-free survival (EFS, primary endpoint) and overall survival (OS) in standard-risk Ewing sarcoma (EWS). PATIENTS AND METHODS: Eligible patients had
