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There has been a rapid rise in papers modelling the impacts of autonomous vehicles. Drawing on a review of this literature, we analyse and discuss the messages conveyed by these studies from a policy-making perspective. An overview of the studies is provided to highlight the different policy frames. We consider the roles that modelling knowledge should have in policy-making in the context of unsta
We investigate the enrichment patterns of several delivery scenarios of the volatiles to the atmospheres of ice giants, having in mind that the only well constrained determination made remotely, namely the carbon abundance measurement, suggests that their envelopes possess highly supersolar metallicities, i.e., close to two orders of magnitude above that of the protosolar nebula. In the framework
Large multiobject spectroscopic surveys require automated algorithms to optimize their observing strategy. One of the most ambitious upcoming spectroscopic surveys is the 4MOST survey. The 4MOST survey facility is a fibre-fed spectroscopic instrument on the VISTA telescope with a large enough field of view to survey a large fraction of the southern sky within a few years. Several Galactic and extr
In this work, atmospheric pollutant emissions of NOx, SOx, CO, particulate matter (PM), total organic compounds (TOC), and CO2 from larger stationary sources of pollutants in Brazil were inventoried and spatialized over the whole Brazilian territory for the base year 2011. The developed inventory comprises a total of 16 refining units, 1730 thermoelectric power plants (TPPs), 96 cement industries,
Climate change researchers argue that a residual domain exists beyond the limits of adaptation to prevent deleterious climate change impacts: this has been labeled as “loss and damage.” Over the last 8 years, there has been significant growth in loss and damage scholarship thus making it imperative to take stock of what we know already and directions for future research. We undertook a quantitativ
The concept of critical performativity–efforts to make critical research more relevant for groups outside academia and develop and communicate action-relevant critical insights with some potential effect–has received considerable interest. Much of this has focused on debates about the core concept and principles. This paper argues for the need to “do”–more than talk about–critical performativity a
Although biologics have revolutionized psoriasis treatment, they pose a significant burden on the healthcare budget. With the wide range of biologics available and the increasing number of biosimilars, insights into the real-world cost per responder (CPR) are required. Therefore, this study aims to evaluate the real-world CPR of adalimumab, ustekinumab, IL17-and IL23-inhibitors, incorporating both
Analyzing kinetic experiments on protein aggregation using integrated rate laws has led to numerous advances in our understanding of the fundamental chemical mechanisms behind amyloidogenic disorders such as Alzheimer's and Parkinson's diseases. However, the description of biologically relevant processes may require rate equations that are too complex to solve using existing methods, hindering mec
The establishment of innovation ecosystems has become an increasingly prevalent strategy for fostering territorial, economic and social development. However, the existing literature provides limited insights into the strategic conditions that enable the emergence of such ecosystems. This paper addresses this gap by identifying the critical elements and mechanisms underpinning their creation. Speci
Winter is a critical bottleneck period for many insects and is particularly pivotal for pest species, being a major regulator of their populations. In winter, insect fruit pests such as the invasive fly, Drosophila suzukii, not only have to cope with harsh environmental conditions but also need to find alternative resources when cultivated fruit are scarce. This study aimed to disentangle the rela
Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship between chronic inflammation and habitual sleep duration is elusive. Here, we study this relation using genetically predicted level of chronic inflammation, indexed by CRP and IL6 signaling, and self-reported sleep duration. By Mendelian randomization analysis, we show that elevated CRP level within <10 mg
Context. Despite the ever-increasing number of known exoplanets, no uncontested detections have been made of their satellites, known as exomoons. Aims. The quest to find exomoons is at the forefront of exoplanetary sciences. Certain space-born instruments are thought to be suitable for this purpose. We show the progress made with the CHaracterising ExOPlanets Satellite (CHEOPS) in this field using
Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathological diagnosis are not available for most neurodegenerative neuropathologies. Here, we present ProtAIDe-Dx, a deep joint-learning model trained on 17,170 patients and controls that uses plasma proteomi
Building materials account for a high percentage of the non-land cost of self-help housing. Few studies, however, have examined the use of building materials by self-help builders and the practicalities of producing and distributing the materials in an alternative manner. This paper discusses the nature of construction by self-help in the intermediate-sized Colombian city of Pereira, focusing in p
The current framing of AI-driven technologies situates them as solutions to a looming care crisis. However, this overlooks informal caregivers' key role to current State budgetary deficits impacting healthcare services happening in Europe. As States increasingly rely on informal caregivers to provide care before the necessary involvement of healthcare services, there is already well-established re
Refugees drown, are beaten, and are pushed back at the borders of the states of the Global North. Moral outrage is understandable in the face of such treatment. But does it constitute a good political theory? Can morality supply us with good normative arguments for a political world? In this article, I argue that they cannot. Drawing on political realism, I show why moral arguments for admitting r
In fixed-bed reactors, the use of large particles in thermally thick regimes is common, which underscores the need for a comprehensive understanding of intraparticle processes. However, integrating detailed particle models into fixed-bed simulations is computationally expensive. This study introduces a tabulation method for biomass conversion’s drying and pyrolysis stages, where significant mass e
Lignins are a polymeric, renewable resource with remarkable structural diversity. Research is being conducted into the valorisation of lignins into value-added products. The absence of experimental libraries, in particular for process-modified oligomers, hampers analytical feedback to these valorisation efforts. Stochastic methods for generating libraries in-silico have been proposed, but were not
