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Importance: Patients with melanoma are selected for sentinel lymph node biopsy (SLNB) based on their risk of a positive SLN. To improve selection, the Memorial Sloan Kettering Cancer Center (MSKCC) and Melanoma Institute Australia (MIA) developed predictive models, but the utility of these models remains to be tested. Objective: To determine the clinical utility of the MIA and MSKCC models. Design
This research tests whether self-labelling with a derogatory or reclaimed label is perceived as an act of reclamation. A pilot study (N = 102) identified English terms used to label lesbian women and gay men. The main study (N = 276) used a between-groups vignette design in which participants read about a woman/man self-labelling with a descriptive (lesbian/gay), reclaimed (queer), or derogatory g
Deep learning has allowed for remarkable progress in many medical scenarios. Deep learning prediction models often require 105–107 examples. It is currently unknown whether deep learning can also enhance predictions of symptoms post-stroke in real-world samples of stroke patients that are often several magnitudes smaller. Such stroke outcome predictions however could be particularly instrumental i
Aviation is a highly inter-connected system. This means that a problem in one area may cause effects in other countries or parts of the Air Transport System (ATS). Examples range from local air traffic disruptions to the 2010 volcanic ash crisis. Agility, like resilience, refers to the ability to cope with dynamics and complexity in a flexible manner, by adjusting and adapting performance and the
A high quality benchmark for small variants encompassing 88 to 90% of the reference genome has been developed for seven Genome in a Bottle (GIAB) reference samples. However a reliable benchmark for large indels and structural variants (SVs) is yet to be defined. In this study, we manually curated 1235 SVs which can ultimately be used to evaluate SV callers ortrain machine learning models. We devel
Ice cores are excellent archives for obtaining long and continuous 10Be records. However, traditional ice core 10Be measurements required a lot of ice (0.5–1kg) and often needed to be connected to a large and costly ice core project. These reasons have been the factors limiting the number and variety of 10Be projects and data. In this paper, we show measurements of 10Be on small samples (∼45g) of
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer worldwide. This study was undertaken to evaluate survival outcomes and changes of disease outcomes of CRC patients over the last decades.METHODS: A retrospective analysis of CRC patients in Christchurch was performed in four patient cohorts at 5 yearly intervals; 1993-94, 1998-99, 2004-05 and 2009. Data on cancer location, stage,
Heparin-binding protein (HBP) is a promising biomarker for the development and severity of sepsis. To guide its use, it is important to understand the factors that could lead to false-positive or negative results, such as inappropriate release and inadequate clearance of HBP. HBP is presumably released only by neutrophils, and the organs responsible for its elimination are unknown. In this study,
Med hjälp av öppna datakällor från svenska myndigheter om vatten och mark vilka sammanställdes i ett QGIS-program var det möjligt att presentera och åskådliggöra vattenbudgeten i Lagans avrinningsområden. Den sammanlagda vattenmängden i avrinningsområdet kunde uppskattas till 9,36 km3 varav 75,9 % (7,10 km3) är grundvatten och 24,1% (2,26 km3) finns i sjöarna i området. Studien pekar på att GISbasUsing open-access data sets on water and soil from Swedish authorities and compiling them in a QGIS-programme made it possible to present and visualise the water budget of the Lagan River Catchment. Based on the estimations of the water volume in groundwater reservoirs and lakes the total maximum available volume in the Lagan River Catchment area was determined to be 9.36 km3. Of this 75.9% (7.10
In order to investigate the possible causes of premature thermal breakdown and performance degradation, several diagnostic techniques have been employed during the vertical tests of the Fine and Large Grain ESS Medium Beta prototypes cavities. The whole equipment, which includes second sound, fast thermometry, photodiode x ray detectors and external NaI scintillator and proportional counter, is he
Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the main embryonic arteries. The onset of circulation triggers several processes that provide critical external factors for HSC generation. Nevertheless, it is not fully understood how and when the onset of circulation affects HSC emergence. Here we show that in Ncx1−/− mouse embryos devoid of circulation the HSC l
Background. School health programs need to target all aspects of physical, psychological, and social well-being. Using a slightly modified version of the COSMIN Risk of Bias checklist, we developed and conducted the first validation of the School Health Assessment Tool for Primary Schools (SHAT-PS). Method. The exploratory sequential mixed method was used in this study. In the first phase, scienti
The purpose of this perspective article is to critically explore the launch of the mission for 100 climate neutral cities in Europe. An overview of the mission approach in general is first presented, where key aspects and emerging critiques are identified. Second, key elements of the mission for 100 climate neutral cities in Europe are introduced along with some of its challenges and ambiguities.
Accuracy in MP2RAGE-based T1-mapping relies on knowledge of the imperfect inversion efficiency (finv) of the inversion pulse. Here we map the inversion efficiency of different adiabatic inversion pulses in human brain at 7T. We identified a mean finv=0.86, which is substantially lower than the finv=0.96 typically assumed in MP2RAGE. We further observed a lower finv in white matter (WM) than in the
The capacitive biosensor technology can be utilized for the analytical detection of a variety of different compounds. By employing the electrical double-layer principle, it is possible to detect very low concentrations of the target analyte due the methods inherent high sensitivity. This affinity-based capacitive biosensor is a powerful tool also for the analytical detection of low molecular weigh
In recent years there has been a great deal of discussion on the potential for a shift away from modernistic or technocratic approaches to decisionmaking on risk towards more open, inclusive, and deliberative approaches. The authors consider (a) the reasons why some companies have taken the first step in this transition by exploring the potential of more open and communicative approaches to enviro
Fast-moving consumer goods (FMCGs) are products that have a short useful lifetime and are typically designed for single or limited uses followed by disposal. The disposable nature of FMCGs combined with ineffective waste recovery systems is causing global environmental problems. Various reusable packaging business models have emerged to tackle these problems; however, their influence is still low
