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Around midnight of 9 January 1959, the Vega de Tera dam broke, releasing nearly 8 million cubic metres of water that destroyed the Spanish town of Ribadelago, killing 144 people. To this day, it remains the worst dam-related failure of the past two centuries of Spanish history. In this chapter we expand the time frame of the disaster, moving from a one-day narrative to focus on the processes of re
BACKGROUND: Achalasia is a rare motility disorder of the esophagus. The diagnosis involves clinical suspicion based on history details and results of high-resolution manometry (HRM) as recommended by the Chicago classification (CCv4.0). Interpreting data obtained through HRM can be complex especially for the novice user.METHODS: We propose therefore a color-based algorithm involving the "reversed
A majority of all infectious diseases manifest some climate-sensitivity. However, many of those sensitivities are not well understood as meteorological drivers of infectious diseases co-occur with other drivers exhibiting complex non-linear influences and feedback. This makes it hard to dissect their individual contributions. Here we apply a novel deep learning Explainable AI (XAI) compartment mod
Probabilistic models of imposed loads require adjustments to reflect current knowledge and experience. To do so, relevant data about their spatial and temporal variability must be collected. Structural Health Monitoring allows to estimate loads acting on bridges by measuring the relevant strains or deflections. Adapting this approach to buildings is not straightforward due to the increased complex
Diabetes is a growing global problem, with hundreds of millions of people living with the disease worldwide. Diabetes can be divided into two major subtypes, autoimmune type 1 diabetes (T1D), and type 2 diabetes (T2D), which has stronger causal links in obesity, lifestyle, and age. Although immunity and inflammation are clearly defined in T1D, it is also understood that inflammation has a role in
Collective action by small-scale farmers can contribute significantly toward rural development. One important aspect that remains relatively neglected, especially in research set in Africa, is the role of farmer collectives in political processes. We study the local-level dynamics of a farmer-based organization mobilizing for agroecology and food sovereignty in Uganda. Through qualitative, collabo
This chapter builds upon three streams of experience by its author: (a) one related to his six-year term as the first UN Special Rapporteur on human rights and counterterrorism (2005-2011), namely the identification of the absence of a proper international definition of terrorism as an important source of human rights abuses, (b) his observation of actual court practice and media coverage where de
Young adults presenting with knee pain, instability, or both after twisting the knee during sports or at work are commonly seen in primary care. If the symptoms and injury history correspond with suspicion of a torn anterior cruciate ligament (ACL) or meniscal injury, sometimes in combination with positive findings on magnetic resonance imaging, patients are often referred for surgical treatment.
The essay offers an outline of classical modern reflection (sociology, cultural theory, literature) on the constitution and transformation of modernity, its cultural and mental dispositions. The discussion focuses on key themes and experiences of classical modernity: void, crisis and abundance. It is argued that classical modernity may be conceived as a conceptual archive of influential ideas on c
Urban areas provide a promising context for upcycling due to the concentration of consumers and existence of bulky waste resources. Hence, upcycling initiatives emerge across European cities, but little is known about their manifestations. Building on interviews with twenty-four stakeholders from the urban upcycling ecosystem and three focus groups sessions, a morphological model was created with
Major Depressive Disorder (MDD) is a leading global health challenge, affecting nearly 5% of the population. Mounting evidence suggests that systemic low-grade chronic inflammation (SLGCI) plays a central role in the development and progression of MDD. This persistent inflammatory state results from unresolved immune activation and sustained exposure to modern lifestyle factors, such as sedentary
Summary Successful malaria transmission from the mosquito vector to the mammalian host depends crucially on active sporozoite motility. Sporozoite locomotion and host cell invasion are driven by the parasite's own actin/myosin motor. A unique feature of this motor machinery is the presence of very short subpellicular actin filaments. Therefore, F-actin stabilizing proteins likely play a central ro
Changes in biomarker levels of Alzheimer’s disease (AD) reflect underlying pathophysiological changes in the brain and can provide evidence of direct and downstream treatment effects linked to disease modification. Recent results from clinical trials of anti–amyloid β (Aβ) treatments have raised the question of how to best characterize the relationship between AD biomarkers and clinical endpoints.
Objective - To screen risk groups for low bone mineral density by quantitative ultrasound in primary health care. Design - Cross-sectional. Intervention - None. Subjects - Risk categories for osteoporosis (a fragility fracture, malabsorption, immobilisation, inflammatory joint disease, glucocorticoid, fenantoin or thyroxin treatment, renal insufficiency or "miscellaneous"), 775 women and 179 men a
Information and Communication Technologies (ICT) have relevant positive and negative impacts on environmental sustainability on various levels: First-order effects such as increasing electronic waste streams; second-order effects such as improved energy-efficiency of production; third-order effects such as a product-to-service shift in consumption or rebound effects in transport. In the simulation
LevMacinstrumentet är ett analysinstrument under utveckling som utnyttjar leviterade droppar på 100 nl ? 2 ?l. Genom att använda leviterade droppar med den omgivande atmosfären som enda kontaktyta, undviker LevMac?en de vanligaste problemen associerade med miniatyrisering av analytiska tekniker, t.ex. kontaminering av provet genom desorption från provbehållaren eller andra gränsytor, adsorption av
The dynamics of ethanol production/consumption in baker's yeast were studied under feed- rate controlled conditions. The yeast was grown on molasses in an 8-l fed-batch reactor and experiments were done at cell concentrations between 5 and 65 g l−1. Small changes in the feed rate were made around a feed rate corresponding to the critical growth rate, at which the yeast cell metabolism switches bet
