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Anomaly detection is the process of identifying unexpected data samples in datasets. Automated anomaly detection is either performed using supervised machine learning models, which require a labelled dataset for their calibration, or unsupervised models, which do not require labels. While academic research has produced a vast array of tools and machine learning models for automated anomaly detecti
Advanced therapies for Parkinson's disease (PD) constitute a broad range of treatments, each presenting specific ethical challenges. Some of these therapies are established and in clinical use, like device-aided therapies, and others, based on advanced therapeutic medicinal products (ATMPs), are still in early stage of clinical trials. This paper focuses on some common ethical issues arising in th
Assignment of the G3m(g) and (b) correlative amino acid residues was performed at the genomic level by direct sequencing of DNA from nine Caucasian individuals. Two oligonucleotide primers were used for subclass-specific enzymatic amplification of a DNA segment comprising a major portion of the second and third constant region domains (CH2 and CH3) fo the human IgG3 heavy chain gene. Comparison of
AimIntraoperative rectal washout is performed to eliminate exfoliated intraluminal cancer cells and thereby decrease the risk of local recurrence. Rectal washout in abdominoperineal resection has not been studied. The aim of this study was to assess the oncological outcome after rectal washout in abdominoperineal resection for rectal cancer and to find evidence as to whether rectal washout should
Background: Community services for Swedish people with intellectual disability (ID) are intended to support self-determination and integrity. Legislation does not allow the use of restrictive or coercive measures. Aim: The aim of this study is to identify the extent of, rationale for, and strategies staff believe would reduce the use of restrictive measures in group homes and daily activities serv
To limit global warming to 1.5°C, fossil fuel use must rapidly decline, but historical precedents for such large-scale transitions are lacking. Here we identify 147 historical episodes and policy pledges of fossil fuel decline in 105 countries and global regions between 1960 and 2018. We analyze 43 cases in larger systems most relevant to climate scenarios. One-half of 1.5°C-compatible scenarios e
NTRU is a lattice-based public-key cryptosystem that has been selected as one of the Round III finalists at the NIST Post-Quantum Cryptography Standardization. Compressing the key sizes to increase efficiency has been a long-standing open question for lattice-based cryptosystems. In this paper we provide a solution to three seemingly opposite demands for NTRU cryptosystem: compress the key size, i
Background: Nail psoriasis (NP) is common and of high importance in patients with psoriasis. Complete resolution of NP at week 24‒26 is an unambiguous nail outcome accessible for indirect treatment comparison of biologics. Objective: To evaluate the comparative efficacy of approved biologics in achieving complete resolution of NP at week 24‒26. Methods: A network meta-analysis (NMA) was conducted
Within the grand sandstone quarries of Gebel el-Silsila is a vast amount of unique symbolic representations; stylized iconographic and pseudo-scripted signs and marks that to some extent signify deities and their protection against demons, evil and mishaps. Like written protective formulae, these marks were placed within the quarries to symbolically safe-keep the quarry workers, and for expressing
BACKGROUND: Phaeochromocytoma is sometimes not diagnosed before surgery and may present as an adrenal incidentaloma. The aim of this study was to investigate differences in clinical presentation and perioperative outcome in patients with subclinical and symptomatic phaeochromocytoma, and in patients operated with and without preoperative α-blockade. METHODS: This was a retrospective observational
Transport energy conservation research in urban transport systems dates back principally to the Organization of the Petroleum Exporting Countries’ (OPEC) “Arab Oil Embargo” (1973–1974) and the Iranian revolution (1979), when global oil supplies became threatened and costs rose steeply. Two subsequent Gulf Wars (1991 and 2003) highlighted the dangerous geo-political dimensions of Middle-Eastern oil
Most countries in Sub-Saharan Africa have made great strides towards more accessible and higher quality schooling and medical systems in recent years. Despite this, education and health care in Africa lag behind other developing regions and large inequalities in educational levels and health care access remain across countries, subnational regions, and gender. Cameroon, in west-central Africa, wit
A radioactive fallout following a nuclear accident can result in contamination of large areas of land. In order to protect human health against ionizing radiation, large-scale decontamination that includes multiple sets of clean-up measures may be necessary. Sweden lacks national experience of this type of large-scale decontamination. There are thus great uncertainties in the effect of such a deco
The panel initiates a discussion on the role of information behaviour research in addressing majorchallenges facing our society. These include climate change, political extremism, and health threats –in many of which information plays a crucial role. The panel asks, first, what is the role andresponsibility of information behaviour research in addressing societal challenges, and second, is therea
The bone marrow microenvironment provides indispensable factors to sustain blood production throughout life. It is also a hotspot for the progression of hematologic disorders and the most frequent site of solid tumor metastasis. Preclinical research relies on xenograft mouse models, but these models preclude the human-specific functional interactions of stem cells with their bone marrow microenvir
Transitioning from linear to circular production systems requires interactions that include cross-sectoral collaboration in networks. Understanding the role of collaboration within these networks can support the transition to a circular economy. To understand cross-sectoral collaborative endeavors, this paper develops a collaboration framework for circular economy by combining and interlinking thr
The mechanical response of a woven eight-harness satin graphite/polyimide composite has been investigated by performing ± 45° tensile and Iosipescu shear tests at room temperature. Nonlinear finite element simulations of the tests have been conducted to determine internal stress distributions in the ±45° tensile and Iosipescu fabric specimens as a function of load. In the experimental part of this
Interferon gamma (IFNγ) is central to the inflammatory immune response, such as that entrained by BCG immunotherapy for bladder cancer. However, immune-mediated tumour cell killing is subject to modulation by immunoinhibitory “checkpoint” receptors such as PD-L1. We investigated the effects of IFNγ on barrier-forming in vitro-differentiated normal human urothelium using mRNA-sequencing, and showed
