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Popular Abstract in Swedish De allra flesta människor har vid något tillfälle tagit ett läkemedel. Till exempel vaccineras nu för tiden alla svenska barn mot bland annat stelkramp. Vad nog de allra flesta däremot inte har gjort är att fundera på vad ett läkemedel är. Kanske sträcker man sig till att ha kollat upp ett läkemedel i FASS, och kanske får man då syn på en figur som består av streck och A method to accurately estimate the binding affinity of a small molecule to a receptor would be indispensable in numerous fields. For instance, most drugs exert their action by binding to a macromolecule target. Thus, a lot of time and resources could be saved in drug design by predicting affinities by computer programs. In a series of 15 papers, we have tested, compared, and improved the most p

An open European market for goods and services, including transport services, stimulates trade, global competitiveness and economic growth. At the same time, concerns about domestic job security, regulation compliance and the environment have sparked a debate. This report should be considered one of the first modest contributions to the mainly unexplored area of European freight deregulation. Our

In patients with drug resistant partial epilepsy, who are under consideration for epilepsy surgery, interictal and ictal EEG recorded with extracranial electrodes plays an important role in the localisation of the seizure onset area. During the past years, methods have been developed, which can be used to estimate the location of the source of epileptiform activity in the brain from extracranial E

Popular Abstract in Swedish Denna avhandling presenterar några reglertekniska tillämpningar i elkraftsystem. Tillämpningarna är: hur likströmskablar påverkar båtrafik som använder magnetkompasser; frekvensmätning i elkraftsystem; algorithmer för datorbaserade reläskydd; koppling av aktiv last för att dämpa effektpendlingar.This thesis presents some control applications in electric power systems. The work consists of the four parts: interaction between DC cables and ship steering autopilots; frequency estimation; computer relaying; field tests using load switching to damp power oscillations. The first three parts are based on four papers that are given in Appendix A-D. The thesis presents supplementary text to these

Aims: To illuminate patients' experiences of being cared for and nurses' experiences of caring for patients in a multiple-bed hospital room. Background: Many patients and healthcare personnel seem to prefer single-bed hospital rooms. However, certain advantages of multiple-bed hospital rooms (MBRs) have also been described. Method: Eight men and eight women being cared for in a multiple-bedroom

Reconstructions of solar activity prior to AD1600 rely on estimates of the past production rates of cosmogenic radionuclides in the Earth’s atmosphere. These rates are modulated by the strength of the solar magnetic field and the intensity of the Earth’s geomagnetic dipole. One of the largest uncertainties associated with these reconstructions originates from palaeointensity data and to show how e

Popular Abstract in Swedish Avhandlingen handlar om ett område i hjärnan som kallas amygdala. Detta området är ansvarigt för att lära sig vad man bör tycka om och vad man skall vara rädd för. I avhandlingen diskuteras hur det här området verkar fungera, och hur det arbetar tillsammans med andra områden för att göra sitt jobb. Dessa reaktioner är primitiva känslor; rädsla, lycka och så vidare. AvhaThe amygdala is a small subcortical structure that has long been implicated in the conditioning of fear and other emotions. It is heavily interconnected to a number of both cortical and subcortical structures and is thus well placed to integrate sensory inputs from multiple areas to produce emotional reactions directly as well as influence learning and attention systems. Data suggests that the amy

Ultrafast lasers are finding many applications in medicine and biology. Pulses from such systems can be used directly or after non-linear modification. Direct utilisation includes time-resolved fluorescence spectroscopy and imaging. Such studies can be performed for tissue diagnosis in the field of malignant diseases as well as in the cardiovascular sector. Two-photon induced fluorescence provides

Studies of apparently homogeneous cell populations and single cells often give highly divergent results. Cells exhibit varying responsiveness to stimuli and gene expression and they are in many aspects stochastic and unpredictable. We have developed a method to measure gene expression quantitatively in individual cells with real-time RT-PCR. mRNA for hormones, ion channels and enzymes in pancreat

A series of twelve full scale experiments with upholstered furniture and beds has been carried out. Ten experiments were performed inside an extensively equipped compartment with a door opening. In order to study the influence of the room on the fire development two experiments were carried out in the open outside the compartment. One experiment in the room was made with restricted ventilation sim

The pine sawfly, Diprion jingyuanensis Xiao et Zhang, is a serious pest of Chinese pine (Pinus tabulaeformis Carr.) in the northern parts of China. The general biology of this recently described sawfly species is little known and in the present study we used a synthetic pheromone to monitor its flight period and to evaluate the possibility to use pheromone traps as a tool for estimating and predic

Background: The ability to adapt and habituate based on prior experiences is important for human movement control, fall prevention and for the ability to enhance performance during various human activities. However, little is known about the ability for the elderly to adapt to balance perturbations in the lateral direction. Objective: To determine whether adaptation, i.e., the ability to adjust po

More than 50 years ago, Fish postulated that a special form of early abnormal neurodevelopment, "pandysmaturation", defined a priori as constituting retarded cranial development in the first year of life, combined with delay in early motor milestone attainment, was related to genetic risk for schizophrenia, and was associated with schizophrenia-spectrum disorders in young adulthood. Fish confirmed

Concentrations of hydroxyl radicals and formaldehyde were calculated using homogeneous (HRM) and stochastic reactor models (SRM), and the result was compared to LIF measurements from an optically accessed iso-octane/n-heptane-fuelled homogeneous charge compression ignition (HCCI) engine. The comparison was at first conducted from averaged total concentrations/signal strengths over the entire combu

Background Achievement of global health goals will require assessment of progress not only nationally but also for population subgroups. We aimed to assess how the magnitude of socioeconomic inequalities in health changes in relation to different rates of national progress in coverage of interventions for the health of mothers and children. Methods We assessed coverage in low-income and middle-inc

Background. For breathing adapted radiotherapy, the same motion monitoring system can be used for imaging and triggering of the accelerator. Purpose. To evaluate a new technique for prospective gated computed tomography (CT) and four-dimensional CT (4DCT) using a laser based surface scanning system (Sentinel(™), C-RAD, Uppsala, Sweden). The system was compared to the AZ-733V respiratory gating sys

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor through which organochlorine contaminants including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and some polycyclic aromatic hydrocarbons induce toxicity and altered gene expression. Atlantic salmon has multiple AHR genes, of which two belong to the AHR1 clade and four belong to the AHR2 clade. The four AHR2 forms (alph

Through rapid reactions with ozone, which can initiate the formation of secondary organic aerosols, the emission of sesquiterpenes from vegetation in Amazonia may have significant impacts on tropospheric chemistry and climate. Little is known, however, about sesquiterpene emissions, transport, and chemistry within plant canopies owing to analytical difficulties stemming from very low ambient conce

Heart fatty acid binding protein (HFABP) is expressed in the brain and is elevated in cerebrospinal fluid (CSF) from patients with several forms of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease with dementia, Lewy body dementia, vascular dementia (VaD), and Creutzfeldt-Jakob disease. However, whether HFABP in CSF is a stable biomarker or if it can help predict co