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BACKGROUND: A growing body of evidence links microRNAs (miRNAs) to major depressive disorder (MDD). However, the causal nature of these associations remains unclear.OBJECTIVES: This study aimed to investigate the potential causal association between miRNAs and MDD by combining Mendelian Randomization (MR) analyses and experimental validation.METHODS: Single-nucleotide polymorphisms (SNPs) signific
Psychological distress, including depression, anxiety, and stress, requires time-efficient assessment tools suited for digital and momentary settings. The Screening Tool for Psychological Distress (STOP-D) is a five-item scale developed for brief mental health screening, but it has not yet been validated in Swedish. This study aimed to evaluate the psychometric properties and diagnostic accuracy o
Drawing on the theoretical framework of ‘relational work’ in economic sociology, the article examines the phenomenon of ‘precarious commitment’ – when employees’ commitment to their work and colleagues simultaneously exposes them to the risk of self-exploitation. The study analyses semi-structured interviews with game developers in the Swedish digital games industry. The article demonstrates the n
To generate the required antiproton beam intensity for the FAIR PANDA experiment, a dedicated proton LINAC (pLINAC) for the FAIR accelerator chain is being constructed. Klystron modulators are power converters within the high-power RF system of the pLINAC. Here, seven modulator systems with a nominal pulse power amplitude of 115 kV / 54 A, an effective pulse width of 360 µs and a pulse repetition
Martian carbonate-bearing rocks are compelling targets for exploration because they preserve detailed records of past aqueous processes, climate, and habitability. The Margin unit in Jezero crater is a distinct olivine- and carbonate-bearing unit stratigraphically underlying the western fan, lining the inner margin of the western crater rim and has a contested origin. Perseverance spent ∼350 sols
Conversational agents are increasingly being introduced in healthcare to enhance access to healthcare and address limited healthcare resources. The aim of this study was to explore experiences of a conversational agent for symptom checking and triage tool assessing the urgency and appropriate level of care implemented in public healthcare from a cognitive accessibility perspective. With a Particip
OBJECTIVES: To identify the lowest sensitivity and specificity that physicians and the general population consider acceptable for medical artificial intelligence (AI), relative to current human performance.METHODS: In a nationwide, cross-sectional survey in Sweden, 2025, random samples of 500 physicians and 500 adults from the general population were mailed a questionnaire presenting three vignett
The optical response of gold-silver (Au-Ag) alloy nanoparticles is strongly influenced by their localized surface plasmon resonance (LSPR), which can be tuned by varying the particle composition. Accurate simulation of LSPR, often performed using Mie theory, critically depends on the choice of dielectric function, yet available datasets for gold, silver, and their alloys vary widely. In this work,
The fields of cultural tourism and heritage management are gaining attention for their potential to be better linked, particularly in terms of practical applications. This paper proposes a taxonomy of heritage resources and related heritage-based tourism types and their linkages for specific case study areas, building on the established product class approach in cultural tourism studies. The resea
A quantitative understanding of the hydro-environmental factors that influence the occurrence of agricultural drought events would enable more strategic climate change adaptation and drought management plans. Practical drought hazard mapping remains challenging due to possible exclusion of the most pertinent drought drivers, and to the use of inadequate predictive models that cannot describe droug
Evaluating the repellency of essential oils against Tetranychus urticae requires robust methodologies to detect time-dependent changes in their efficacy, due to differential efficacy, volatility, and sustained effectiveness. This study introduces the Pole-dance bioassay, a novel no-choice method optimized for high-throughput screening of time-dependent repellency, demonstrated through tests on twe
Along with the gradually accelerated urbanization process, simulating and predicting the future pattern of the city is of great importance to the prediction and prevention of some environmental, economic and urban issues. Previous studies have generally integrated traditional machine learning with cellular automaton (CA) models to simulate urban development. Nevertheless, difficulties still exist
In this essay I discuss different normative foundations - theories of political ethics, for proposed cures to market failures. In addition to empirically match what cure fit what type of market failure, I posit the notion that the normative position of an economist, or policy maker, or of a group, concerned with these problems, delimits the options available for recommending, or analysing, what co
The purpose of this qualitative study is to explore how the Swedish community support organizations BUFFF and Solrosen support children and youths with incarcerated parents with a focus on how they address stigma, provide safe spaces, and help prevent intergenerational criminality. Through semi-structured interviews with professionals from both organizations, this thesis examines how these childre
The North Atlantic region is a key component of the climate system via large-scale atmosphere and ocean circulation. Climate field reconstructions can provide a long-term context for ongoing climate change and contribute to our understanding of climate dynamics, impact of external forcings, and act as references for model evaluation and baseline for natural variability. There are distinct differen
Between 2024 and 2026, AI providers launched dedicated agent products and presented them as tools that can plan, decide and carry out marketing tasks with greater independence than earlier generative AI. On LinkedIn, Swedish marketing executives and industry opinion leaders produce a parallel discourse that reaches the same professional audience. This study examines how the relationship between th
BackgroundNearly 10% of the global population living with dementia resides in South Asia, a region of over two billion people with limited diagnostic and care resources. Clinicians require accessible, flexible, and contextually relevant training to improve dementia care in frontline settings.AimTo develop, pilot, and implement a multi-modal, interactive, hybrid training program to improve clinicia
There is a need to closer characterise the molecular changes associated with progression from low to high mortality stage cutaneous T cell lymphoma. This has been challenging since there is high inter-patient heterogeneity in the genetics and transcriptomics of the malignant T cell populations. Modern technology has enabled single-cell resolution as well as spatially guided cell selection for whol
This thesis explores how Employee-Driven Innovation (EDI) unfolds within Swedish municipal organizations and identifies how EDI is managed and structured, and what kind of innovations that are created in such organizational environments. While innovation is increasingly emphasized in the public sector, this study reveals that its practice is far from uniform. Through qualitative studies of three m
