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Background: The emergence of disease-modifying Alzheimer’s (AD) treatments provides new hope to patients and families but concerns have been raised about the preparedness of healthcare systems to provide timely access to such treatments because of a combination of a complex diagnostic process and a large prevalent pool. Objectives: We assess the preparedness of Sweden, a high-income country known
The objectives were to translate the University of Jyvaskyla Active Aging Scale (UJACAS) to Swedish, to establish semantic equivalence and evaluate psychometric properties for use among persons 55 years and older in Sweden. The UJACAS contains 17 items to be self-assessed regarding goals, abilities, opportunity, and activity. Psychometric properties content validity, data quality including floor a
Contaminated sites constitute a global problem as they pollute important freshwater systems at a local scale. To effectively address these sites for remediaton, we must first characterize the sites in order to gain an understanding of the geological setting. This step is crucial as it helps determine groundwater flow pathways and the dynamics of surface water-groundwater exchange within these syst
Last June, the stem cell community came together to celebrate the 20th anniversary of the International Society for Stem Cell Research (ISSCR), one of the leading organizations in the field. The hybrid event mixed a varied program filled with plenary talks, concurrent track sessions, poster presentations, exhibit booths, and plenty of opportunities to enhance stem cell research through bonding bet
The CORDEX Flagship Pilot Study ELVIC (climate Extremes in the Lake VICtoria basin) was recently established to investigate how extreme weather events will evolve in this region of the world and to provide improved information for the climate impact community. Here we assess the added value of the convection-permitting scale simulations on the representation of moist convective systems over and ar
Flooding and wildfires are two common natural hazards in Sweden to which the Fire and Rescue Services (FRS) must be prepared to respond to. In light of potential increases in these hazards, the Extreme-Index project aims to develop such a multi-hazard tool for Sweden. In this paper, a modular multi-hazard framework is presented. The first module of the multi-hazard methodology that is developed an
Bio-based and patient-specific three-dimensional (3D) scaffolds can present next generation strategies for bone tissue engineering (BTE) to treat critical bone size defects. In the present study, a composite filament of poly lactic acid (PLA) and 45S5 bioglass (BG) were used to 3D print scaffolds intended for bone tissue regeneration. The thermally induced phase separation (TIPS) technique was use
In this study, an algae biomass gasification process using a dual fluidized bed with combined power and methanol cogeneration was developed. The gasification process was modeled using Aspen Plus and validated using experimental data of two microalgae species (Nannochloropsis oculata and Dunaliella salina) commonly found on the western coast of Saudi Arabia. The impacts of different operating condi
Shaw’s Pygmalion is commonly thought of as an adaptation of the myth of Pygmalion, the sculptor who fell in love with his own sculpture. However, the name of “Pygmalion” in ancient mythology is shared by Dido’s brother, Pygmalion of Tyre. This article suggests Pygmalion as playing with these two mythological Pygmalions by moving through the play from the myth of Pygmalion the Cypriot sculptor to t
Reclassification of bridges, i.e., a change in load rating, using reliability-based methods and a direct update with proof load information has been presented by many authors. However, bridge reclassification has hardly been studied from a decision analytic perspective, i.e., with quantification of the risks and benefits of different classification choices, and the expected benefit gain from proof
This paper presents a production study investigating the frequency of utterance-final rises in South Swedish. These rises are interesting from a dialect typological perspective. Recent findings suggest that South Swedish has two-peak accents utterance medially, whereas previous typologies have assumed only one-peak accents for South Swedish dialects. The South Swedish two-peak accents are similar
Objective: Primary stenting of the superficial femoral artery (SFA) in intermittent claudication (IC) has been shown to increase health related quality of life (HRQoL) after 12 and 24 months. An extended follow up of HRQoL 36 and 60 months after randomisation is presented. Methods: A multicentre randomised controlled trial was conducted at seven vascular clinics in Sweden between 2010 and 2020. On
Green infrastructure (GI) is increasingly used in policymaking to promote biodiversity and enhance ecosystem services through the protection, creation, restoration and connection of natural and man-made green areas. The EU Commission adopted in 2013, the concept as a strategy. When member states apply the policy, it is translated into specific bureaucratic and political systems, creating different
PMCA4 is a critical regulator of Ca2+ homeostasis in mammalian cells. While its biological and prognostic relevance in several cancer types has already been demonstrated, only preclinical investigations suggested a metastasis suppressor function in melanoma. Therefore, we studied the expression pattern of PMCA4 in human skin, nevus, as well as in primary and metastatic melanoma using immunohistoch
The transition from fossil jet fuel to biojet fuel is an important step towards reducing greenhouse gas (GHG) emissions from aviation. To enable such a fuel shift, the Swedish Government introduced a GHG emission reduction mandate of 27% by 2030 for aviation fuel sold in Sweden, forcing fuel suppliers to blend in biojet fuel in fossil jet fuel. A similar policy instrument is being discussed within
Latest generations of district heating and cooling systems are characterised by low network temperature with uninsulated pipes, decentralised heat pumps and chillers to modulate the network temperature, and shared energy flows between interconnected buildings. This paper presents a simulation model for the design and analysis of these systems. The model was developed using the Modelica language an
ABSTRACT: Radiation dosimetry is central to virtually all radiation safety applications, optimization, and research. It relates to various individuals and population groups and to miscellaneous exposure situations-including planned, existing, and emergency situations. The International Commission on Radiological Protection (ICRP) has developed a new computational framework for internal dose estima
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 ×
