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Multiple studies have demonstrated that cancer cells with microsatellite instability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-stable (MSS) cancer cells are not. Therefore, WRN represents a promising new synthetic lethal target for developing drugs to treat cancers with MSI. Given the uncertainty of how effective inhibitors of WRN activity will prov
Accessible design enables participation in the digital society for everyone. However, cognitive accessibility is not well established within the field of web design. The International Classification of Functioning, Disability and Health (ICF) provides a descriptive framework that relates health conditions to functioning and participation. ICF Core Sets are purposefully tailored shortlists of ICF c
To predict major pressure losses from pumping shear thinning liquid foods and beverage, rheometer-measured flow behaviour (n) and flow consistency (K) indices are needed. These are always obtained with some measurement uncertainty. This contribution develops a tool that allows for quantitatively estimating how a given measurement uncertainty in the rheological parameters translate to predictio
Background: Rare disease clinical trials are notorious for complexities that frequently result in study-start delays. However, there is limited knowledge about how participants and researchers perceive these delays and what factors shape their experiences. A clinical trial in the rare, progressive disorder Pantothenate Kinase-Associated Neurodegeneration—the PKAN trial—encountered an unexpected de
Recent droughts from 2017 to 2020 induced significant stress on woodland canopies across eastern Australia, resulting in widespread tree browning and mortality. However, the trajectory of post-drought recovery remains unclear, with uncertainty about whether canopy conditions are improving or continuing to decline. Identifying the key local environmental and climatic factors influencing drought-ind
BackgroundDespite the high morbidity and severe consequences of epidermolysis bullosa (EB), current treatments remain inadequate, lacking efficacy and the ability to target the microbial and inflammatory components of EB wounds. In this first-in-human open-label, single-arm study—part 3 of a 3-part Phase 1 clinical trial—we examined the safety, tolerability, and systemic exposure of topically appl
Background and hypothesis Knowledge regarding access to first kidney transplantation (KT) and subsequent KT in patients commencing kidney replacement therapy (KRT) in childhood is limited. Methods Using European Renal Association (ERA) Registry data, we investigated European patients who started KRT below 20 years of age between 1978 and 2019. Access and determinants to first, second, and third KT
Climate change is one of the major drivers of biodiversity loss. Among vertebrates, amphibians are one of the more sensitive groups to climate change due to their unique ecology, habitat requirements, narrow thermal tolerance and relatively limited dispersal abilities. We projected the influence of climate change on an endemic toad, Malabar Tree Toad (Pedostibes tuberculosus; hereafter MTT) from t
The governance of agricultural resources, particularly seeds, has long been a site of contestation between corporate-aligned institutions promoting proprietary seed laws and smallholder farmers, civil society organisations, and food sovereignty advocates defending traditional seed systems and local control. In Ghana, the introduction and eventual passage of the Plant Variety Protection Act of 2020
The Siusi/Seis section has been measured for the δ13C signature across the Permian-Triassic Boundary (PTB) in high resolution on magnetostratigraphic samples from Scholger et al. (2000), enabling an exact correlation with magnetostratigraphic data. We show that the base of the short normal polarity magnetozone that has been reported from the evento-stratigraphic boundary correlates with a distinct
Tensor-valued encoding in diffusion MRI allows probing of microscopic anisotropy in tissue, however, time-dependent diffusion (TDD) can bias results unless b-tensors are carefully tuned to account for TDD. We propose two novel strategies for tuning b-tensors to enable accurate measurements without interference from TDD due to restricted diffusion. The first strategy involves identifying encoding t
A large pulse of atmospheric Cl-36 generated by a limited number of nuclear tests peaked in the late 1950s to early 1960s. The corresponding enhanced Cl-36 deposition is seen in various glaciological archives in the Northern Hemisphere. The profile of the bomb spike recorded in firn layers at Vostok Station, central East Antarctica. has been measured by employing accelerator mass spectrometry (AMS
Caloric restriction has been found to be protective against the development of type 2 diabetes mellitus (T2D) in experimental animal studies. However, studies examining this association in humans are limited. In the present study, we examined whether individuals with anorexia nervosa, one marker of severe caloric restriction in humans, have a low incidence of T2D by using several Swedish registrie
Popular Abstract in Swedish Bukspottkörteln (pankreas) består av en sekretorisk (exokrin) del, som producerar pankreassaft innehållande olika matspjälkningsenzymer vilka medverkar vid nedbrytningen av födan i tarmen, samt en hormoninsöndrande (endokrin) del, som producerar insulin och andra hormon vilka reglerar näringsomsättningen i kroppen. Vid en underproduktion av enzymer, exokrin pankreatisk Exocrine pancreatic insufficiency (EPI), resulting from disease (e.g. cystic fibrosis, chronic pancreatitis) or surgery (e.g. pancreectomy or pancreas duct ligation), leads to disorders in the digestive system, such as, maldigestion, malabsorption and finally malnutrition. Pancreatic duct-ligated (PDL) pigs have been used as a suitable large-animal model to study the conditions and treatment of EP
Popular Abstract in Swedish Inom processanalytisk kemi är uppgiften att bestämma viktiga egenskaper i en kemisk process under det att tillverkningen fortlöper. Ett vanligt exempel är att man bestämmer halten av något ämne. Eftersom de uppmätta egenskaperna ofta används för att styra processandet mot bästa möjliga betingelser är det av generellt intresse att mätningen går snabbt. Men det är inte noPharmaceutical tablets and pellets are often covered with a coating. There is a need for methods that enable monitoring of the growth of such films during processing. Such analyses can be performed using process analytical chemical methods based on near infrared (NIR) diffuse reflectance spectrometry. It provides with analyses that take only ca. 8 seconds in total analysis time, including physical
Intumescent coating is an important fire protection method for steel structures. Traditionally its fire properties have been evaluated by performing furnace tests using a standardized test procedure and following a standardized time-temperature curve. This procedure is restrictive in performance based fire safety engineering design since it limits the fire condition to the standard one only. In th
