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Fifty patients with haemophilia B, belonging to 29 kindreds, were investigated with a highly sensitive immunoradiometric assay based on a homologous antibody to factor IX. The assay measures factor IX antigen (f.IX:Ag) in plasma down to 0.025 U/dl. Seventeen of 18 investigated patients with severe haemophilia B had very little or no f.IX:Ag. Also four of nine patients with moderately severe diseas
Background: Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy across subgroups of GFR, age, body mass index (BMI) and gender uncertain. To overcome this, a large cohort of children referred for GFR determination has been established from se
Production of chiral amines using omega-transaminases has been thoroughly studied in recent years. Immobilized w-transaminases, however, have been used on relatively few occasions despite potential benefits such as reuse of enzyme and ease of product purification. In this study principally different methods including surface immobilization, entrapment and sweep flocculation using titanium oxide. C
This study is an attempt to take advantage of a cerebellar model to control a biomimetic arm. The cerebellar controller is a modified MOSAIC model which adaptively controls the arm. We call this model ORF-MOSAIC (Organized by Receptive Fields MOdular Selection And Identification for Control). The arm features a musculoskeletal model which is controlled through muscle activations by means of optimi
Correct time and frequency synchronization is important for the performance of orthogonal frequency division multiplex (OFDM) systems. We evaluate a system where a pseudonoise sequence (PN-sequence) is used for estimation of these synchronization parameters. The PN-sequence is superimposed on the OFDM signal. The system is evaluated by means of the variance of the frequency estimation error and th
The Late Ludlow topmost Hemse-Burgsvik succession includes more substantial and more rapid facies changes than most older and younger intervals on Gotland. A revised conodont zonation for this interval includes three zones, the Polygnathoides siluricus, the Icriodontid, and the Ozarkodina snajdri zones and four subzones, the Upper P. siluricus, the Lower, the Middle and the Upper Icriodonfid subzo
Objective. To describe the change of pain reports over time in 3 cohorts derived from the general population: (1) no chronic pain (NCP, n = 1156); (2) chronic regional pain (CRP n = 502) and (3) chronic widespread pain (CWP; n = 242). To identify risk factors that predict the development or persistence of chronic widespread pain. Methods. A 3-year followup from 1995 to 1998 with postal questionnai
A rheological study of mixed micelles formed by PEO-PPO-PEO triblock copolymer P123 and nonionic surfactant C12EO6 in aqueous solutions has been carried out with the purpose of investigating the time dependence of a shape transition of the mixed micelles and characterizing the shape before and after the transition. The rheology results presented in this report give clear evidence that the P123-C12
Fetal mesencephalic mouse tissue, rich in dopamine neurons, was xenografted as a dissociated cell suspension into the striatum of rats with unilateral 6-hydroxydopamine induced lesions of the mesostriatal pathway. The rats were either assigned to a 10-day, 21-day or 42-day Cyclosporin A (CyA) immunosuppression scheme, or given no immunosuppression. The functional effects of the grafts were followe
PURPOSE: To evaluate the effect of intraocular pressure (IOP)-reducing treatment on the development of disc hemorrhages in patients with glaucoma. DESIGN: Prospective cohort study of patients in the Early Manifest Glaucoma Trial, followed up to 11 years (median = 8 years). PARTICIPANTS: Patients with newly detected glaucoma randomized to argon laser trabeculoplasty plus betaxolol (n = 129) or no i
Insights into how exactly a fly powers and controls flight have been hindered by the need to unpick the dynamic complexity of the muscles involved. The wingbeats of insects are driven by two antagonistic groups of power muscles and the force is funneled to the wing via a very complex hinge mechanism. The hinge consists of several hardened and articulated cuticle elements called sclerites. This art
A detailed understanding of excited-state evolution is critical to realizing the full potential of abundant-metal coordination complex photosensitizers. Here, we show how wide-band optical transient absorption spectroscopy (oTA) can delineate the complete energy relaxation pathway of the photoexcited state of Fe(ii) polypyridyl complexes supported by benzannulated diarylamido ligands. By covering
Investigations of past fires suggest that building occupants faced with a fire have problems defining the severity of it, especially in the early stages of the fire. An experiment was therefore carried out to study people’s ability to estimate fire growth, and their perceived ability to extinguish a fire using a portable fire extinguisher. A total of 535 persons, namely 304 men and 231 women, were
Background The alpha-emitter radium-223 (Ra-223) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone-refractory prostate cancer. We aimed to study mature outcomes from a randomised, multicentre, phase II study of Ra-223. Methods Patients with hormone-refractory prostate cancer and bone pain needing external-beam radiotherapy were assigned to fou
This study investigates several commercial selective catalytic reduction (SCR) catalysts (A–E) for application in a high-temperature (approximately 525 °C) and high-concentration (5000 ppm NO) system in combination with CO2 capture. The suggested process for removing high concentrations of NOx seems plausible and autothermal operation is possible for very high NO concentrations. A key property of
