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Solvent cage-escape dynamics of bimolecular photoredox products in solution has been investigated computationally through a combination of molecular dynamics simulations and quantum chemical calculations. The present work focuses on the photoinduced oxidation of the organic electron donor dimethylaniline (DMA) by a Fe(III) N-heterocyclic carbene photosensitizer (Fe(III)NHC+) in two different solve
We use a closed-loop algorithm to accurately program hafnium zirconium oxide (HZO) ferroelectric tunnel junctions (FTJs) to arbitrary chosen target conductance values. The key enabler is suppression of conductance growth. We have identified two different mechanisms contributing to the total conductance of FTJs. By controlling both, we demonstrated an up to threefold increase of the usable conducta
BACKGROUND AND OBJECTIVE: BRCA1 and BRCA2 pathogenic germline variants (PGVs) are associated with higher risk of prostate cancer (PC). The IMPACT study evaluated the utility of targeted prostate-specific antigen (PSA) screening in BRCA1/BRCA2 PGV carriers. Here we report outcomes after five rounds of PSA screening in IMPACT.METHODS: Between 2005 and 2015, 3063 participants aged 40-69 yr (median 54
The interactions between aerosols and clouds are still one of the largest sources of uncertainty in quantifying anthropogenic radiative forcing. To reduce this uncertainty, we must first determine the baseline natural aerosol loading for different environments. In the pristine and hardly accessible polar regions, the exact nature of local aerosol sources remains poorly understood. It is unclear ho
Purpose: A multimodal artificial intelligence (MMAI) biomarker was developed using clinical trial data from North American men with localized prostate cancer treated with definitive radiation, using biopsy digital pathology images and key clinical information (age, PSA, and T-stage) to generate prognostic scores. This study externally validates the biomarker in a prospective, real-world dataset of
Since N. v. the United Kingdom, an exceptionally high threshold has been applied to migrants who try to avoid expulsion in order to continue to receive medical assistance in the returning state. With Paposhvili v. Belgium, the Grand Chamber of the ECtHR recognized the ensuing protection gap and modified the standards. These modifications imply a small opening of the ‘very exceptional’ standard to
Objectives: Asthma and allergic diseases are the most frequent chronic diseases in childhood worldwide, and considered a burden for the affected children and their families. The diseases impose an economic burden on society if not diagnosed and treated properly and management of and these diseases are challenging for healthcare professionals. The aim of the present investigation was to assess the
Inom ett par år kommer det nya materialforskningscentret ESS, The European Spallation Source, att stå färdigbyggt. Det kommer då vara det mest avancerade forskningsinstitutet i sitt slag och leverera upp till 30 gånger fler neutroner än någon annan neutronkälla i världen. En av de viktigaste komponenterna på ESS är det s.k. strålmålet som består av nästan 7000 bitar av det metalliska grundämnet voThe European Spallation Source (ESS), which is currently under construction in Lund, will use pure tungsten as the spallation neutron target. The tungsten will be irradiated by a 2 GeV proton beam, pulsed at a repetition rate of 14 Hz. Each pulse will deposit 357 kJ in the tungsten causing an instantaneous temperature rise of approximately 100 °C, during the 2.86 ms pulse duration. The target is w
Nucleation and growth of SBA-15 silica nanostructured particles with well-defined morphologies has been followed with time by small-angle X-ray scattering (SAXS) and ultrasmall-angle X-ray scattering (USAXS), using synchrotron radiation. Three different morphologies have been compared: platelets, toroids, and rods. SEM observations of the particles confirm that two key physical parameters control
Fifty patients with haemophilia B, belonging to 29 kindreds, were investigated with a highly sensitive immunoradiometric assay based on a homologous antibody to factor IX. The assay measures factor IX antigen (f.IX:Ag) in plasma down to 0.025 U/dl. Seventeen of 18 investigated patients with severe haemophilia B had very little or no f.IX:Ag. Also four of nine patients with moderately severe diseas
Background: Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy across subgroups of GFR, age, body mass index (BMI) and gender uncertain. To overcome this, a large cohort of children referred for GFR determination has been established from se
Fathers are expected to play an increasing part in the care of children, but fathers are not automatically included in studies of early childhood. In this paper we present Swedish fathers' experiences of child health care. In the study, a total of 237 out of 279 (85%) fathers of small children were telephone interviewed using a structured questionnaire. As many as 165 (70%) had visited the child h
Production of chiral amines using omega-transaminases has been thoroughly studied in recent years. Immobilized w-transaminases, however, have been used on relatively few occasions despite potential benefits such as reuse of enzyme and ease of product purification. In this study principally different methods including surface immobilization, entrapment and sweep flocculation using titanium oxide. C
This study is an attempt to take advantage of a cerebellar model to control a biomimetic arm. The cerebellar controller is a modified MOSAIC model which adaptively controls the arm. We call this model ORF-MOSAIC (Organized by Receptive Fields MOdular Selection And Identification for Control). The arm features a musculoskeletal model which is controlled through muscle activations by means of optimi
Crystal plasticity models are often used to model the deformation behavior of polycrystalline materials. One major drawback with such models is that they are computationally very demanding. Adopting the common Taylor assumption requires calculation of the response of several hundreds of individual grains to obtain the stress in a single integration point in the overlying FEM structure. However, a
Second derivative regularization methods for dense stereo matching is a topic of intense research. Some of the most successful recent methods employ so called binary fusion moves where the combination of two proposal solutions is computed. In many cases the fusion move can be solved optimally, but the approach is limited to fusing pairs of proposals in each move. For multiple proposals iterative b
The great decline in mortality has had a vital impact on our societies. Life expectancy has more than doubled in the past 200 years, but no acceptable explanation has yet been given for the earlier part of the decline in mortality, even though it has attracted a very broad interdisciplinary interest. When carefully examined, many of the stated explanations, such as better hygiene, more food, and i
