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The molybdenum cofactor is an important cofactor, and its biosynthesis is essential for many organisms, including humans. Its basic form comprises a single molybdopterin (MPT) unit, which binds a molybdenum ion bearing three oxygen ligands via a dithiolene function, thus forming Mo-MPT. In bacteria, this form is modified to form the bis-MPT guanine dinucleotide cofactor with two MPT units coordina
Solid oxide cells are an exciting technology for energy conversion. Fuel cells, based on solid oxide technology, convert hydrogen or hydrogen-rich fuels into electrical energy, with potential applications in stationary power generation. Conversely, solid oxide electrolysers convert electricity into chemical energy, thereby offering the potential to store energy from transient resources, such as wi
Purpose: In addition to incisional hernia, inguinal hernia is a recognized complication to radical retropubic prostatectomy. To compare the risk of developing inguinal and incisional hernias after open radical prostatectomy compared to robot-assisted laparoscopic prostatectomy. Method: Patients planned for prostatectomy were enrolled in the prospective, controlled LAPPRO trial between September 20
Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer, consisting of 32 private and public stakeholders from 9 countries across Europe. Launched by the Innovative Medicines Initiative 2 and part of the Big Data for Better Outcomes Programme (BD4BO), the overarching goal of PIONEER is
Background: Artificial intelligence (AI) systems can potentially aid the diagnostic pathway of prostate cancer by alleviating the increasing workload, preventing overdiagnosis, and reducing the dependence on experienced radiologists. We aimed to investigate the performance of AI systems at detecting clinically significant prostate cancer on MRI in comparison with radiologists using the Prostate Im
It is generally known that, unlike structured proteins, intrinsically disordered proteins, IDPs, exhibit various structures and conformers, the so-called conformational ensemble, CoE. This study aims to better understand the conformers that make up the IDP ensemble by decomposing the CoE into groups separated by their radius of gyration, Rg. A common approach to studying CoE for IDPs is to use low
Human reproductive success requires both producing children and making investments in the development of offspring. To a large extent these investments are made by the parents of the child, but researchers are now looking beyond the nuclear family to understand how extended kin, notably grandmothers, enhance reproductive success by making transfers to progeny of different kinds. The extent to whic
Objectives: In this nationwide cohort study in a Scandinavian setting, we aimed to investigate the magnitude of association between flucloxacillin use and drug-induced liver injury (DILI). Methods: Nationwide cohort study among adults in Sweden, 2006–2018, was conducted. Register data on filled prescriptions, patient characteristics, co-medications, and DILI were linked. All filled prescriptions f
Background: Children aged 0–18 years who need long-term respiratory support rely on medical technology and comprehensive medical care. For this care to be provided at home, access to medical and social support and care is essential. In Sweden, the most notable form is personal care assistance (PCA), which is granted based on legislation and individual authority decisions. We aim to explore the imp
Premise of research. Selfing rates in mixed-mating plant species are often found to fluctuate greatly across time and space. Environmentally induced changes in floral traits may mediate changes in selfing rates through several mechanisms, including direct effects via changes in traits influencing autofertility rates and indirect effects via changes in traits affecting the rate of pollinator visita
The paper presents digital nomads’ experiences about the support of digital technologies in relation to social isolation. Despite the abundant access to digital technologies for organizational cooperative purposes, the challenge of social isolation constitutes one of the central concerns in nomadicity practices, affecting employees’ choice of working arrangements. To gain further knowledge on the
Bimetallic nanoparticles have gained significant attention in catalysis as potential alternatives to expensive catalysts based on noble metals. In this study, we investigate the compositional tuning of Pd–Cu bimetallic nanoparticles using a physical synthesis method called spark ablation. By utilizing pure and alloyed electrodes in different configurations, we demonstrate the ability to tailor the
Standardized Cancer Patient Pathways (CPPs) were introduced in Swedish healthcare starting in 2015 to improve diagnostics for patients with symptoms of cancer, patient satisfaction and equity of care between healthcare providers. An inclusion target and a time target were set. Our primary aim was to visualize the patient population going through CPPs, in terms of investigation time and indications
a-particle emitters are emerging as a potent modality for disseminated cancer therapy because of their high linear energy transfer and localized absorbed dose profile. Despite great interest and pharmaceutical development, there is scant information on the distribution of these agents at the scale of the a-particle pathlength. We sought to determine the distribution of clinically approved [223Ra]R
Antibiotic resistance poses a global threat. Antibiotics are administered to 80-90% of terminally ill patients but evidence of their effectiveness in improving survival or symptom relief at the end of life (EOL) is scarce. To determine the proportion of deceased patients that continue antibiotic treatment after documented EOL discussion and the decision to prioritise symptom relief over active tre
