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The Online Remote Behavioural Intervention for Tics (ORBIT) trial found that an internet-delivered, therapist-supported, and parent-assisted Exposure and Response Prevention (ERP) intervention reduced tic severity and improved clinical outcomes. This process evaluation aimed to explore mechanisms of impact and factors influencing efficacy. Participants were 112 children with a tic disorder and the
The Last Interglacial (LIG) experienced substantial changes in seasonal insolation compared with the present day, which may have affected the hydrography and water-mass exchange in the North Sea and Baltic Sea region. Here we investigate the effects of solar radiation and greenhouse gas (GHG) forcing on the regional climate by analyzing model simulations of the LIG (127 ka BP), pre-industrial (PI,
Sex is a pervasive factor that underpins functional phenotypic variation across a range of traits. Although sex can usually be distinguished morphologically, in some species this is not possible. The development of genetic markers for sex identification is, thus, key if we are to incorporate sex into an understanding of ecological or evolutionary process. Here we develop genetic markers for the id
The R2 protein of ribonucleotide reductase catalyzes the dioxygen- dependent one-electron oxidation of Tyr122 at a diiron-carboxylate site. Methane monooxygenase and related hydroxylases catalyze hydrocarbon hydroxylation at diiron sites structurally related to the one in R2. In protein R2, the likely reaction site for dioxygen is close to Phe208. The crystal structure of an iron ligand mutant R2,
We report on local nowcasting (short-term forecasting) of coronavirus disease (COVID-19) hospitalizations based on syndromic (symptom) data recorded in regular healthcare routines in Östergötland County (population ≈465,000), Sweden, early in the pandemic, when broad laboratory testing was unavailable. Daily nowcasts were supplied to the local healthcare management based on analyses of the time la
Background: There is an urgent need for effective treatments against glioblastoma (GBM). In this trial, we investigated the efficacy and safety of an adoptive cell-based immunotherapy. Methods: Patients with newly diagnosed GBM were recruited at 4 study sites in Sweden. The patients were randomized 1:2 to receive either radiotherapy (RT), 60 Gy/30 fractions, with concomitant and adjuvant temozolom
The process to elaborate a legally binding instrument on Business and Human Rights started in 2014. The stated ambition animating UN process is to deliver a broad-spectrum treaty that significantly increases remediation for victims. However the treaty has polarized opinion from the very beginning. To come closer to genuine points of disagreement and possible paths forward, this chapter explains an
Silene alba Muhl. ex Britton (1893), although considered to be an illegitimate substitution for S. nivea (Nutt.) Otth, is validly published and as a result S. alba (Miller) E. H. L. Krause (1901), the widely used name for the weed white campion or white cockle, is illegitimate. It is shown that the correct name for this species in Silene is S. pratensis (Rafn) Godron & Gren. A new taxonomic tr
Many nanoadsorbents are reported in the literature, exhibiting remarkable properties in the removal of low concentrations of toxic metals. However, their environmental performance has not yet been well studied. A life cycle assessment (LCA) was carried out for a previously reported nanomaterial-based adsorbent, silicate-titanate nanotubes chitosan beads (STNTs-Ch beads), used to remove cadmium fro
Atrial cardiomyopathy, characterized by abnormalities in atrial structure and function, is associated with increased risk of adverse cardiovascular and neurocognitive outcomes, independent of atrial fibrillation. There exists a critical unmet need for a clinical tool that is cost-effective, easy to use, and that can diagnose atrial cardiomyopathy. P wave parameters (PWPs) reflect underlying atrial
Background: The combination of diphenylcyclopropenone (DCP) and anthralin may demonstrate synergistic effects in the treatment of chronic extensive alopecia areata (AA).Objective: The objective of the study was to compare the efficacy of the combination therapy of topical DCP and topical 0.5% anthralin versus topical DCP alone for the treatment of chronic extensive AA.Materials and Methods: Ten pa
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expressi
In its proposed 2023 Critical Raw Materials Act, the European Commission considers access to critical raw materials within its territory as key to both the green transition and to reduce import dependencies. This onshoring of extractivist practices warrants a critical analysis that reflects on the justice implications this may have for local communities. Therefore, I apply an integrated post-struc
Uppsatsen handlar om vilka faktorer det är som gör att förvaltningsbeslut och förvaltningsmål karaktäriseras som tviste- eller brottmålsliknande. Denna karaktärisering leder i sin tur till att förvaltningsbeslutet eller förvaltningsdomen vinner negativ rättskraft så hinder föreligger för ny prövning av samma sak. Myndighetsbeslut och förvaltningsdomar vinner som huvudregel inte negativ rättskraftThis note analyzes the factors that determine whether administrative decisions and opinions are characterized as civil proceedings or criminal proceedings. This characterization, in turn, determines whether the prohibition on double jeopardy (so called “legal force”) applies, so that there is a barrier to a new trial of the same issue. In the paper, the rules on enforceability are the same in the
The production and use of chemicals has grown exponentially over the past 50 years. Although the knowledge of hazards and risks associated with chemicals towards humans and the environment has increased, we know frightenedly little about how dangerous these might become when part of finished products. Companies now need to be more concerned about which chemicals exist in their products. For the co
Border carbon adjustment is an economic instrument being discussed more frequently as a possible solution to address carbon leakage, which is an issue for many developed countries. Developed countries are showing interest in this instrument to protect domestic industries from carbon leakage to countries that do not tax carbon. There is however concerns from developing countries that border carbon
To stay within our planet’s limits and reach the United Nation’s Sustainable Development Goals, there is an urgent need to rethink our current and dominant systems. This thesis focuses on the food system, in particular, and explores how an overarching turnaround in the way we produce and consume food has the potential to trigger and steer a greater transition towards sustainability. However, this
In recent years, corporate branding and its potential benefits on brand performance has become an increased area of interest for both researchers and communication professionals. This study aims to deepen and increase knowledge about the concept of corporate brand identity and its influence on brand performance in the communications sector and answer the research question; How do the dimensions of
