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Nuclear magnetic resonance (NMR) spectroscopy was used in order to investigate the relationships between structure, dynamics and calcium binding in the intracellular regulatory protein, calmodulin. Calmodulin consists of two similar domains, each binding two calcium ions with positive cooperativity. The studies described in this thesis focus on the isolated C-terminal domain, TR2C, and two mutants
The kinetics of structure change when dispersions of two different types of lipid-based liquid-crystalline phases, one lamellar and one reversed, are mixed has been investigated using synchrotron small-angle X-ray diffraction and ellipsometry. The systems studied were (i) cubic-phase nanoparticles (CPNPs) based on glycerol monooleate (GMO) stabilized with a nonionic block copolymer, Pluronic F-127
MAX-lab is a national synchrotron radiation facility in Lund. Nowadays, the MAX project consist of three facilities (three storage rings). A new storage ring is needed to improve material science, such as nanotechnology. MAX IV, also in Lund, will be 100 times more efficient than already existing synchrotron radiation facilities. The storage ring is controlled by a large number of magnets that are
The association between a randomly pyrene labeled PAA polymer (PAAMePy55) and a PEO-PPO-PEO triblock copolymer (P123) in aqueous solutions of different NaCl concentrations and pHs has been studied by means of dynamic light scattering (DLS) and steady-state fluorescence spectroscopy at 40 °C. At acidic pH values, in the low P123/PAAMePy55 molar ratio regime (i.e., at low P123 concentrations), the r
The increase of complexity of public services in the modern era proposes requirements for the coordination and cooperation between the public sectors. Inter department coordination mechanism is one of the very important part in government management and it becomes a global trend. No matter in the US, Japan, Korea or UK, setting up one kind of special organization to do the coordination between dif
Background: Most in vitro studies of potential osteoarthritis (OA) therapies have used cartilage monocultures, even though synovium is a key player in mediating joint inflammation and, thereby, cartilage degeneration. In the case of interleukin-1 (IL-1) inhibition using its receptor antagonist (IL-1Ra), like chondrocytes, synoviocytes also express IL-1 receptors that influence intra-articular IL-1
STUDY QUESTION: Which substances and signal transduction pathways are potentially active downstream to the effect of FSH and LH in the regulation of human oocyte maturation in vivo? SUMMARY ANSWER: The regulation of human oocyte maturation appears to be a multifactorial process in which several different signal transduction pathways are active. WHAT IS KNOWN ALREADY: Many studies in animal species
Context. TOI-1055 is a Sun-like star known to host a transiting Neptune-sized planet on a 17.5-day orbit (TOI-1055 b). Radial velocity (RV) analyses carried out by two independent groups using nearly the same set of HARPS spectra have provided measurements of planetary masses that differ by ∼2σ. Aims. Our aim in this work is to solve the inconsistency in the published planetary masses by significa
Evidence from neuropathological cohorts indicates that a CSF α-synuclein (α-syn) seed amplification assay (SAA) might provide quantitative kinetic parameters correlating with α-syn pathology burden in patients with Lewy body disease (LBD). Studies are needed to assess their longitudinal trend during the presymptomatic and clinical disease phases and their correlation with measures of disease progr
Introduction Breast cancer-related lymphoedema (BCRL) at the arm and/or trunk/breast is a highly feared complication following breast cancer treatment and can be objectified using the state-of-The-Art criteria based on volume, extracellular water ratio or skin thickness measurements. Although the incidence of objective BCRL is decreasing due to advances in breast cancer treatment, many patients re
BACKGROUND: Before this study started, the standard postoperative chemotherapy regimen for stage II-III Wilms' tumour pretreated with chemotherapy was to include doxorubicin. However, avoidance of doxorubicin-related cardiotoxicity effects is important to improve long-term outcomes for childhood cancers that have excellent prognosis. We aimed to assess whether doxorubicin can be omitted safely fro
Aims. We aim to demonstrate the scientific potential of the Gaia Early Data Release 3 (EDR3) for the study of different aspects of the Milky Way structure and evolution and we provide, at the same time, a description of several practical aspects of the data and examples of their usage. Methods. We used astrometric positions, proper motions, parallaxes, and photometry from EDR3 to select different
Background: Persons with clinical onset of Alzheimer’s disease (AD) before 65 years of age are diagnosed with early-onset AD (EOAD). The prevalence of EOAD is low, but varies among studies from 6% to 16%. Most individuals with EOAD are still working, have an active social life, and might have children living at home. Therefore, the consequences of being diagnosed early with a disease that implies
Dealing with water diffuse pollution is a major problem for watershed managers. This problem raises many complicated questions, which are important to answer in order to reach water environment protection goals. This study suggested some possible answers for the country of Lithuania. Among them were the identification of critical source areas, the identification of sensitive areas and the applicat
The Sahel lies in the semi-arid zone of North Africa between the Sahara Desert to the north and the savannas and rainforest to the south. In the Sahel, the variability of vegetation growth is predominately controlled by moisture reception in the concurrent rainy season. The inter-annual variability of normalized difference vegetation index (NDVI) during the rainy season (April to August) can be ex
One of most ancient food preservation methods is freezing because there are not caused significant changes the sensory characteristics and nutritional value of foods. Last decade, have been made great steps for the optimization of freezing tolerance of fresh vegetables, fruits and species. Cold injury occurs when the cells are exposed to temperatures lower than 0oC. Cold injury is a consequence of
När någon har betalat ett för stort belopp i den felaktiga tron att det fanns en betalningsskyldighet aktualiseras läran om condictio indebiti. För att princi-perna ska kunna tillämpas krävs att betalningen saknar rättsgrund. En rätts-grund för betalningen föreligger om det finns en avtalsrättslig grund för den, eller om betalningen utgjort en disposition. Huvudregeln enligt condictio indebiti är When someone has overpaid in the mistaken belief that there was an obliga-tion to pay, the doctrine of condictio indebiti comes into play. For the princi-ples to be applicable, the payment must have no legal basis. A legal basis for the payment exists if there is a contractual basis for it, or if the payment con-stituted a disposition. The general rule of condictio indebiti is that the payment mus
Introduction: Today, 3D printing is a versatile tool used in a wide range of fields. With the advent of more cost-effective fused deposition modelling (FDM) 3D printing technologies it is time to investi- gate what such a 3D printer has to offer in radiation science applications. This master thesis will inves- tigate if there is a possibility to use a FDM 3D printer to construct an optically stimu
