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Background. The procedure of human islet isolation needs further optimization and standardization. Here, we describe techniques to enhance enzymatic digestion and minimize mechanical forces during the digestion process. The isolation protocol has also been modified to meet current GMP (cGMP) standards. Moreover, the impact of donor- and process-related factors was correlated to the use of islets f
Policymakers in publicly funded health-care systems are frequently required to make intricate decisions on which health-care services to include or exclude from the basic health-care package. Although it seems likely that the concept of individual responsibility is an essential feature of such decisions, it is rarely explicitly articulated or evaluated in health policy. This paper presents a tenta
This thesis is a summary of five papers concerning endocyclic cleavage of glycosides and related acetals. Simple lactol ethers undergo endocyclic cleavage to give acyclic chain extended products on treatment with organoaluminium and organotitanium reagents. The first examples where organotitanium reagents induced alkylative endocyclic cleavage of carbohydrates is presented. The best conditions for
We present a detailed study of the electronic structure and the stability of C-60 dianions in the gas phase. Monoanions were extracted from a plasma source and converted to dianions by electron transfer in a Na vapor cell. The dianions were then stored in an electrostatic ring, and their near-infrared absorption spectrum was measured by observation of laser induced electron detachment. From the ti
We describe how upper limb amputees can be made to experience a rubber hand as part of their own body. This was accomplished by applying synchronous touches to the stump, which was out of view, and to the index finger of a rubber hand, placed in full view (26 cm medial to the stump). This elicited an illusion of sensing touch on the artificial hand, rather than on the stump and a feeling of owners
Objective: To assess available evidence on the use of end-points ( outcome measures) in clinical trials in systemic lupus erythematosus (SLE), as a part of the development of evidence-based recommendations for points to consider in clinical trials in SLE. Methods: The European League Against Rheumatism (EULAR) Task Force on SLE comprised 19 specialists, a clinical epidemiologist and a research fel
Popular Abstract in Swedish Ny innovativ processdesign har resulterat i två processer som kan göra tillverkningen av förnyelsebara plaster och bränslen konkurrenskraftiga mot dagens fossila alternativ. Den nya designen har gjort vissa processteg upp mot 40 gånger så effektiva som med dagens teknik. Vikten av att ställa om dagens samhälle, som till stor del är beroende av fossila resurser, till eIt is important to replace fossil resources such as oil, coal and natural gas with renewable raw materials for the production of materials and fuels in order to reduce environmental impact. Furthermore, these raw materials should preferably be residues, e.g. agricultural or forest residues, in order not to compete with the production of human food and animal feed. High molecular weight arabinoxyla
This study aims to investigate the impact of foreign aid on economic growth by using an exogenous instrument identified by Galiani et al. (2015). Researchers have through the years failed to agree on whether aid causes growth, being unable to identify an exogenous instrument that can eliminate the endogeneity problem associated with aid and growth. Galiani et al. (2015) claim to have found such an
One of the Amazon´s most endangered species is the small New World primate, ´pied tamarin´ (Saguinus bicolor). The species only occurs in the vicinity of the Brazilian Amazonas state capital city Manaus, where greatly scattered and fragmented small patches of highly degraded forest remain. The on-going growth of Manaus urban area has created habitat fragments where the pied tamarins now try to per
Allergic rhinitis is a common disease affecting millions of people worldwide. Biocare Copenhagen A/S, a Danish biotechnology company decided to screen a number of probiotic lysates, with the aim to identify suitable strains with potential anti-allergic properties, that could regulate production of cytokines and divert the immune system in a regulatory or tolerant mode. People suffering from aller
More and more often we hear about animals as a part of social work. The idea of animals having positive effects on peoples’ physical and psychological health seem to be generally accepted among both active practitioners in the human service professions and the general public. We established two main purposes. First we examined which effects of animal assisted social work the active practitioners i
As organisations increasingly seek to leverage data for artificial intelligence (AI) analytical use-cases, one of the main challenges towards value realisation is effective use of data governance. Existing research on the topic of data governance focuses on technical and structural aspects of data governance, while this thesis identifies human-centred organisational success factors for data govern
Access to reliable electricity is essential for delivering safe and effective healthcare. However, many rural healthcare facilities in Mozambique operate without power or experience frequent and prolonged outages. This thesis investigates the potential of repurposed end-of-life (EoL) lithium-ion batteries (LiBs) as an energy storage solution in such contexts. Based on fieldwork in local settings
This work presented the working scheme developed and used in order to conduct multiple daylight simulations for distinct rooms in a wide range of apartment buildings within the urban grid. The objective was to generate 3D models of the rooms under study and their urban surroundings, and to obtain the corresponding illuminance files and geometry information in a time-efficient, automated manner. Th
Previous studies have identified implementation problems connected to sustainable mobility. These difficulties raise the question of which strategies can be successfully pursued to break path dependencies in urban policy making. This article is focused on corporate mobility management as one specific example of sustainable mobility initiatives, and analyses the formation and implementation of a tr
Background and purpose — Patients having a total knee arthroplasty (TKA) after a previous high tibial osteotomy (HTO) constitute a minor group among those undergoing primary TKA for knee osteoarthritis (OA). There have been few reports on whether such patients differ pre- and postoperatively from those who undergo TKA as the first measure. We evaluated patient characteristics, knee-related pain, f
Within the insect order Lepidoptera (moths and butterflies), the so-called nonditrysian superfamilies are mostly species-poor but highly divergent, offering numerous synapomorphies and strong morphological evidence for deep divergences. Uncertainties remain, however, and tests of the widely accepted morphological framework using other evidence are desirable. The goal of this paper is to test previ
