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Tantalum spectra, emitted from a hollow cathode, have been recorded with a Fourier transform spectrometer in the region 2000–5000 Ů The observed hyperfine patterns of Ta II have been analyzed, yielding center-of-gravity wavelengths for 199 lines and hyperfine constants for 38 even and 97 odd levels of Ta II. Improved energy level values have been derived. The laboratory data have been used for a s
Gaboxadol (THIP; 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) is an agonist at GABA(A) receptors. THIP concentrations (0.01-50 mM) were applied rapidly to Sf9 cells expressing the human alpha(1)beta(2)gamma(2S) GABA(A) receptors. The EC50 values for the peak current in THIP alone or THIP plus 1 muM diazepam were 154 and 53 muM, respectively. In supersaturating THIP (10-50 mM) the rate of curren
Pathogenic bacteria have developed complex and diverse virulence mechanisms that weaken or disable the host immune defense system. IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic cleavage at the lower hinge of human IgG. This p
The Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK) double mutant N45D/N64D was identified during a previous directed evolution study. This mutant enzyme had a decreased activity towards the natural substrates and decreased feedback inhibition with dTTP, whereas the activity with 3'-modified nucleoside analogs like 3'-azidothymidine (AZT) was nearly unchanged. Here, we identify the mut
Bilayer-forming lipids were shown to be ineffective in sustaining the enzymatic activity of violaxanthin de-epoxidase. On the other hand, non-bilayer-forming lipids, regard-less of their different chemical character, ensured high activity of violaxanthin de-epoxidase, resulting in conversion of violaxanthin to zeaxanthin. Our data indicates that the presence of lipids forming reversed hexagonal st
Thread-Level Speculation can be used to take advantage of multicore architectures for web applications. We have implemented Thread-Level Speculation in the state-of-the-art JavaScript engine V8 instead of using an interpreted JavaScript engine. We evaluate the implementation with the Chromium web browser on 15 popular web applications for 2, 4, and 8 cores. The results show that it is beneficial t
Denna avhandling handlar om teoretisk partikelfysik. Partikelfysik handlar om elementarpartiklar och hur dessa växelverkar med varandra, dvs vilka krafter som verkar mellan dem. Detta är hur materien ser ut på den minsta skala vi har kunnat studera experimentellt. Den teori som beskriver de starka, svaga och elektromagnetiska krafterna och de materiepartiklar som vi känner till, kvarkar och lepton
Constant volume combustion is studied, using a zero-dimensional model, which is a wide-ranging chemical kinetic simulation that allows a closed system of gases to be described on the basis of a set of initial conditions. The model provides an engine- or reactor-like environment in which the engine simulations allow for a variable system volume and heat transfer both to and from the system. The com
Beginning in 2002, the Department of Health (DoH) n partnership with the National Institute of Clinical Excellence (NICE) began publishing guidelines for the evidenced-based care and treatment of individuals with specific psychiatric disorders. With few exceptions the first-line psychological treatment recommended in all of the guidelines was some form of CBT. The publications of these guidelines
We report on preliminary results from time-resolved optical spectroscopy of the He-rich variable white dwarf GD 358.
Engineering design problems are most frequently charac-terized by constraints that make them hard to solve and time-consuming. When evolutionary algorithms are used to solve these problems, constraints are often handled with the generic weighted sum method or with techniques specific to the prob-lem at hand. Most commonly, all constraints are evaluated at each generation, and it is also necessary
A combustion system was developed to burn a low value gas in the VT4400 IGT engine demonstrator. The combustor was designed in an engine configuration consisting of a single LCV combustor operating in combination with six LP combustors.
