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The advent of diffraction-limited storage rings (DLSRs) has boosted the brilliance or coherent flux by one to two orders of magnitude with respect to the previous generation. One consequence of this brilliance enhancement is an increase in the flux density or number of photons per unit of area and time, which opens new possibilities for the spatiotemporal resolution of X-ray imaging techniques. Th
Background: With a trend toward de-escalation of axillary surgery in breast cancer, prediction models incorporating imaging modalities can help reassess the need for surgical axillary staging. Although mammography is routinely performed for breast cancer imaging, its potential in nodal staging remains underutilized. This study aims to employ advancements in deep learning (DL) to comprehensively ev
Treatment with chemotherapy, radiotherapy, or surgery that involves reproductive organs can cause impaired spermatogenesis, testosterone deficiency, and physical sexual dysfunction in male pubertal, adolescent, and young adult cancer survivors. Guidelines for surveillance and management of potential adverse effects could improve cancer survivors' health and quality of life. Surveillance recommenda
A search for a heavy neutral Higgs boson, A, decaying into a Z boson and another heavy Higgs boson, H, is performed using a data sample corresponding to an integrated luminosity of 139 fb- 1 from proton–proton collisions at s=13 TeV recorded by the ATLAS detector at the LHC. The search considers the Z boson decaying into electrons or muons and the H boson into a pair of b-quarks or W bosons. The m
The development of good writing skills is fundamental not only to publish scientific results, but also to have a deeper understanding of complex subjects. However reports from the Swedish Higher Education Authority from 2012-2015 suggest that engineering students at Lund University have unsatisfactory academic writing skills. Our paper investigates how students of the Faculty of Engineering at Lun
The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a library of 75–78 clinically relevant drugs. We included 132 viable tumor samples from 35 pediatric oncology centers in seven countries. DSP was conducted on mult
Time-resolved analysis of photon cross-correlation function g(2)(τ) is applied to photoluminescence (PL) of individual submicrometer size MAPbI3 perovskite crystals. Surprisingly, an antibunching effect in the long-living tail of PL is observed, while the prompt PL obeys the photon statistics typical for a classical emitter. We propose that antibunched photons from the PL decay tail originate from
BACKGROUND: Digital modalities which enable asynchronous learning, such as audio podcasts and videos demonstrating procedures, may benefit acquisition and retention of knowledge and clinical skills. The main objective of this nationwide cross-sectional survey study was to evaluate key aspects and factors related to usage of audio podcasts and procedural videos in anaesthesiology and intensive care
Mexico has experienced the dramatic escalation of crime and violence in an organized form since the 1990s, and have also witnessed the highest number of homicides in the last ten years. It has adversely affected the national security, economic growth and social development with an especially detrimental effect on youth in Mexico. This study examines the direct and indirect impacts of drug trade-re
The selective oxidation of alcohols to corresponding carbonyl compounds is essential in academia and industry. Benzil and BHMF have emerged as important classes of carbonyl compounds that have shown promising applications in materials and drug intermediates, especially in sustainable bio-based plastics. The traditional selective oxidation process generally uses equivalent amounts of oxidants or to
Background: CD40 agonists have the potential to enhance the efficacy of standard of care chemotherapy and to trigger antitumor immunity. Preclinical models indicate that the success of this approach depends on appropriate sequencing of chemotherapy with a CD40 agonist. Preliminary efficacy results from the OPTIMIZE-1 Phase II study (NCT04888312) combining mitazalimab (anti-CD40) with mFFX chemothe
This thesis explores some of the possibilities of demand side optimization in online advertising, specifically how to evaluate and bid optimally in real time bidding. Theory for many types of optimizations is discussed. The thesis evaluates auctions from a game theory and control theory perspective. It also discusses how big data sets can be used in real time, and how agents can explore unknown st
In this thesis the heating area of a belt furnace for annealing metal powder has been modeled. The model was extended with PI-controllers for controlling the energy added to the model. It was simulated with differently tuned controllers to test tuning principles for finding suitable control parameters for the process. The most promising tuning principles was then written as a manual with the aim f
The Safe Driving Test (SDT) is a software test performed in a real vehicle where the software is flashed to an ECU and connected to the CAN network in the vehicle. The test driver then conducts different driving scenarios according to the test instructions of the SDT. All the data during testing is logged and then evaluated manually by a test engineer. The entire process including testing, evaluat
Syfte: Syftet med studien är att undersöka effekten av ett kartläggningsbesök med efterföljande telefonuppföljning på användande av kommunikationsstrategier och hörselrelaterad livskvalitet för individer med betydande hörselnedsättning (TMV4 60-69 dB HL på bättre örat). Metod: Ett kartläggningsbesök utformades där fokus låg på individen och dennes upplevda besvär kring den egna hörselnedsättningen
Using data from the Health Behaviour in School-aged Children survey on smoking behaviors for roughly 440,000 European youths over the years 2001-2018, we show that a one euro increase in cigarette excise taxes reduces smoking prevalence (share of children who has smoked) by 2 percentage points using a two-way fixed effects model. This translates to a participation elasticity of -0.1, implying yout
In this study, the quantitative relationship between the three dimensions of transformative capacity – cognitive, structural and agency – and the climate change performance of countries is examined. To do this, indexes are created and panel data regressions conducted. The result indicates a significant negative relationship between the cognitive and diversity dimension index and climate change per
