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pnas201303829 1..6 Generation of induced neurons via direct conversion in vivo Olof Torpera,b, Ulrich Pfisterera,b,1, Daniel A. Wolfa,b,1, Maria Pereiraa,b, Shong Laua,b, Johan Jakobssona,b, Anders Björklunda,2, Shane Grealisha,b, and Malin Parmara,b,2 aDepartment of Experimental Medical Science, Wallenberg Neuroscience Center, and bLund Stem Cell Center, Lund University, 221 84 Lund, Sweden Contr

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/torper.pdf - 2026-06-26

Particles with functional groups on their surface were immobilized on premade cryogels through covalent bonding to maximize the accessibility of the target molecules to the surface of the particles. The physical properties of the composite cryogel were characterized by SEM, texture analysis and nitrogen adsorption. Different key factors affecting immobilization were also investigated, e.g., recirc

Resolving challenges related to the sustainability of natural capital and ecosystem services is an urgent issue. No roadmap on reaching sustainability exists; and the kind of sustainable land use required in a world that acknowledges both multiple environmental boundaries and local human well-being presents a quandary. In this commentary, we argue that a new globally consistent and expandable syst

Accumulated carbon uptake, apparent quantum yield (AQY) and light-saturated net CO2 assimilation (A(sat)) were used to assess the responses of photosynthesis to environmental conditions during spring for three consecutive years. Whole-tree chambers were used to expose 40-year-old field-grown Norway spruce trees in northern Sweden to an elevated atmospheric CO2 concentration, [CO2], of 700 mu mol C

OBJECTIVE: To illuminate the lived experience of women facing the threat of lossing their newborn child and then experiencing the reality of their infant's death. STUDY DESIGN: Sixteen women were interviewed approximately 2 years after the death of their infant using a hermeneutic phenomenological approach. FINDINGS: The main theme was ambivalent transition into motherhood. The women went through

Today, driver support tools intended to increase traffic safety, provide the driver with convenient information and guidance, or save time are becoming more common. However, few systems have the primary aim of reducing the environmental effects of driving. The aim of this project was to estimate the potential for reducing fuel consumption and thus the emission of CO, through a navigation system wh

Interest in using the press-joining method for joining of thin sheets has increased during recent year, especially in the car industry. This is mostly a result of the economic advantages and the ability to join coated or unweldable sheets. With increased knowledge about those parameters that affect the press-joining process, the possibility of reducing or avoiding unwanted deviations in production

Solving the simplified model of the Hartree-Fock Bogoliubov equation in coordinate space with the correct asymptotic boundary conditions, the spin-orbit splitting, occupation probabilities, effective pair-gap, mean square radius, and spin-response function are studied for weakly bound p neutrons. As the binding energy of p3∕2 neutrons becomes small or approaches zero, the spin-orbit splitting p3∕2

Popular Abstract in Swedish Vill man ta en bild av något som rör sig mycket snabbt, krävs det att man använder en kort exponeringstid. Om kamerans slutare är öppen under för lång tid, hinner det man vill fotografera röra sig under tiden filmen exponeras, med resultatet att bilden blir suddig. Kemiska reaktioner där atomer och molekyler är inblandade är exempel på något som sker på väldigt kort tidWhen a low-frequency laser pulse is focused to a high intensity in a gas, the electric field of the laser may become comparable to, or even exceed, the electric field between the electrons and the nucleus in the atom. Under such conditions, through a process known as high-order harmonic generation, bursts of extreme ultraviolet radiation may be emitted, with durations in the attosecond domain (1 a

V/P(SPECT) has the potential to become a first hand tool for diagnosis of pulmonary embolism based on standardized technology and new holistic interpretation criteria. Pretest probability helps clinicians choose the most appropriate objective test for diagnosis or exclusion of PE. Interpretation should also take into account all ventilation and perfusion patterns allowing diagnosis of other cardio

Accurate characterization of the astrometric errors in the forthcoming Gaia catalogue is essential for making optimal use of the data. Using small-scale numerical simulations of the astrometric solution, we investigate the expected spatial correlation between the astrometric errors of stars as function of their angular separation. Extrapolating to the full-scale solution for the final Gala catalog

1. The rising levels of atmospheric carbon dioxide concentration ([CO2]) and temperature have the potential to substantially affect the terrestrial water and energy balance by altering the stomatal conductance and transpiration of trees. 2. Many models assume decreases in stomatal conductance and plant water use under rising [CO2], which has been used as a plausible explanation for the positive g

Astrocytic glutamate (Glt) uptake keeps brain interstitial Glt levels low. Within the astrocytes Glt is converted to glutamine (Gln), which is released and reconverted to Glt in neurons. The Glt-Gln cycle is energy demanding and impaired energy metabolism has been suggested to cause low interstitial Gln/Glt ratios. Using microdialysis (MD) measurements from visually noninjured cortex in 33 neuroin

Mental illness in a hospital in a medium-sized town in Sweden was studied. Consecutive case records from 1896 to 1905, and also from 2011, were selected. In the historical sample, neurasthenia was the most common diagnosis, followed by affective disorders and alcohol abuse. ICD-10 diagnoses corresponded well with the historical diagnoses. Melancholia resembled modern criteria for depression. Mania

Changes in the vascular plant flora of Skåne after the latest published flora (Tyler et al. 2007) until 2015 are reported. 256 taxa are new, and 13 taxa that are new or were earlier regarded as ephemeral, are now regarded as resident. Localities of new taxa and of taxa which had 1–3 localities reported in the previous flora are also included. Redeterminations are included as well as a few cases ofChanges in the vascular plant flora of Skåne after the latest published flora (Tyler et al. 2007) until 2015 are reported. 256 taxa are new, and 13 taxa that are new or were earlier regarded as ephemeral, are now regarded as resident. Localities of new taxa and of taxa which had 1–3 localities reported in the previous flora are also included. Redeterminations are included as well as a few cases of

The bit-search generator (BSG) was proposed in 2004 and can be seen as a variant of the shrinking and self-shrinking generators. It has the advantage that it works at rate 1/3 using only one LFSR and some selection logic. We present various attacks on the BSG based on the fact that the output sequence can be uniquely defined by the differential of the input sequence. By knowing only a small part o

We demonstrate the assembly of nanoscale ferromagnetic single-electron transistors using atomic force microscopy for imaging as well as for nanoscale manipulation. A single 30 nm Au disc, forming the central island of the transistor, is manipulated with angstrom precision into the gap between a plasma-oxidized Ni source and drain electrodes. The tunnel resistances can be tuned in real time during

Diffusion of a particle through an energy and diffusivity landscape is a very general phenomenon in numerous systems of soft and condensed matter. On the one hand, theoretical frameworks such as Langevin and Fokker-Planck equations present valuable accounts to understand these motions in great detail, and numerous studies have exploited these approaches. On the other hand, analytical solutions for

Large grazers are known to affect ecosystem functioning even to the degree where ecosystems transition to another vegetation state. Alongside the vegetation change, several features of ecosystem functioning, such as ecosystem carbon sink capacity and soil carbon mineralisation rates, may be altered. It has remained largely uninvestigated how the grazing effects on carbon cycling processes depend o