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A long and winding road: Differentiating human embryonic stem cells into dopaminergic neurons

Parkinson’s disease is a progressive neurodegenerative disorder. Since the motor manifestations of the disease is associated with the loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta, cell replacement therapy is a promising approach for treatment. Although several different cell types have been used in clinical trials, with the recent findings of somatic cell nuclear tr

Thermo- and chemosensitive properties of Transient Receptor Potential Ankyrin 1 ion channels

The ability to sense and accommodate to an ever-changing environment is crucial for the survival of living organisms. Transient Receptor Potential (TRP) ion channels comprise a large superfamily of cation conducting membrane proteins that function as molecular sensors in diverse sensory processes including perception of light, taste, smell, sound, touch and temperature. The TRP Ankyrin 1 (TRPA1) i

Tolerance induction with T cell-dependent protein antigens induces regulatory sialylated IgGs

Background: Under inflammatory conditions, T cell-dependent (TD) protein antigens induce proinflammatory T-and B-cell responses. In contrast, tolerance induction by TD antigens without costimulation triggers the development of regulatory T cells. Under both conditions, IgG antibodies are generated, but whether they have different immunoregulatory functions remains elusive. Objective: It was shown

What does maintenance of infrastructure mean for pedestrians and cyclists – A knowledge summary

This report summarises knowledge concerning the impact of the maintenance of bicycle and pedestrianinfrastructure. The aim of the literature review was to compile existing knowledge on operation andmaintenance of the transport infrastructure for pedestrians and cyclists, the highlight how operation andmaintenance affect pedestrians and cyclists, in terms of accessibility, safety and security. The

MDC Neck Shoulder - Social Insurance Agency

2023-09-29ContentsData from the Social Insurance Agency (Försäkringskassan) on disability pension (DP), number of sick-leave days and periods, sick-leave diagnoses. The individuals were followed from the MDC baseline screening date until they got disability pension or long-term sick-leave, emigrated, died, turned 65 years of age, or until December 31 2005 when the study ended.Lines: 7 086Variables

https://www.malmo-kohorter.lu.se/malmo-kost-cancer-mkc/datainsamling-mkc/mdc-neck-shoulder-social-insurance-agency - 2026-05-05

Attitudes and beliefs regarding umbilical cord clamping among midwives, obstetricians, and neonatologists in Sweden: A national cross-sectional survey

ObjectiveThe study aimed to explore attitudes and beliefs among midwives, obstetricians, and neonatologists regarding umbilical cord clamping practices, including scenarios involving neonatal compromise. The study was conducted in the context of exploring the potential for implementing intact cord resuscitation.Study designA national cross-sectional survey was administered electronically, using an

Closed-Loop Combustion Control for a 6-Cylinder Port-Injected Natural-gas Engine

High EGR rates combined with turbocharging has been identified as a promising way to increase the maximum load and efficiency of heavy-duty spark ignition engines. With stoichiometric conditions a three-way catalyst can be used which means that regulated emissions can be kept at very low levels. Obtaining reliable spark ignition is difficult however with high pressure and dilution. There will be a

Bayesian Formulation of Image Patch Matching Using Cross-correlation

A classical solution for matching two image patches is to use the cross-correlation coefficient. This works well if there is a lot of structure within the patches, but not so well if the patches are close to uniform. This means that some patches are matched with more confidence than others. By estimating this uncertainty, more weight can be put on the confident matches than those that are more unc

A place to play - Children's design threaded in the urban fabric of Rosengård.

In urban areas, the battle of space is more important than ever. The spaces and environments we grow up in are shown to be crucial for the identity we develop throughout our childhood. Therefore, the way our cities are designed and developed can largely impact who we become. The whole perception of society starts with children’s play, yet we tend to deprioritize their playing environments. For dec