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CD40 plays a central regulatory role in the immune system and antibodies able to modulate CD40 signalling may consequently have a potential in immunotherapy, in particular for treatment of lymphomas and autoimmune disease like multiple sclerosis. As a first step to achieve this goal, we describe the selection and characterization of a novel set of fully human anti-CD40 antibody fragments (scFv) fr
Abstract in UndeterminedWhite layer formation is considered as a part of minimum array of parameters characterizing surface integrity of the machined product. The paper is aimed on identification and characterization of white layer generated when finish turning aged Inconel 718 with Al2O3-SiCw ceramic tools under different cutting conditions, tool wear and coolant application. As expected intensit
Populärvetenskaplig sammanfattning Evolution av stabilitet i ett rovdjur-bytessystem För att göra en matematisk modell av hur rovdjur och byten växelverkar med varandra ställer man upp varsin ekvation för populationernas tillväxthastighet. Dessa beskriver hur rovdjuren och bytena beror av varandra och tiden. Eftersom rovdjuren är beroende av att äta byten för att överleva påverkar de bytespopulaAbstract This master's thesis aim to see if fluctuations in the environment can make a stable predator-prey system naturally evolve into an unstable system. In the paper “Prey adaptation as a cause of predator-prey cycles” (Evolution, 1997), Abrams and Matsuda uses numerical methods to investigate the stability properties of a predator-prey system and looks at the effect that the unstable pop
Today, people are interested in health and environmental issues as well as variety when it comes to food. The project aimed to introduce Japanese food culture in Sweden as a healthy and sustainable choice. Many cooking experiments and food tastings were made and investigated topics such as which character of the food can be liked and disliked, how different ways of serving/ presenting food could i
This bachelor thesis is based on a fear of a growing consumption behavior where short lived life cycles of products are causing negative affects on our attempts of building long and healthy relationships to products. The work is also based on a hope of designing products that people are able to appreciate over long period of time. What is it that makes people value and appreciate desig
The EC provisions on fiscal State aid have since 1997 become an important part of the work against harmful tax competition. The application of the State aid rules to harmful measures is a reversal of the common direction of aid (i.e. leading to preferential tax treatment). This creates several interest-ing legal problems, for example if these rules provide a suitable method to tackle harmful tax c
I det svenska straffsystemet åtnjuter alla brottsliga gärningar ett straffvärde. Så även narkotikabrott. För snart ett år sedan, i juni 2011, avkunnade HD en dom som tydligt syftade till att ändra praxis avseende hur straffvärdet ska fastställas i narkotikamål. De två tilltalade som åtalet huvudsakligen avsåg dömdes av HovR till 14 års fängelse vardera. HD sänkte straffen till fyra års fängelse. EAccording to Swedish penal law all criminal offenses deserves a penal val-ue. So while drug offenses. Nearly a year ago, in June 2011, the Supreme Court gave a judgment that was clearly aimed at changing practices in the assessment of the penal value of drug offenses. The two defendants in the indictment were each mainly sentenced by the Court of Appeals for 14 years in prison. The Supreme Court r
The global impact of LRRK2 mutations is yet to be realized with a lack of studies in specific ethnic groups, including those of Asian and African descent. Herein, we investigated the frequency of common LRRK2 variants by complete exon sequencing in a series of publicly available African American Parkinson's disease patients. Our study identified three novel synonymous exonic variants and 13 known
The orchid family is the largest in the angiosperms, but little is known about the molecular basis of the significant variation they exhibit. We investigate here the transcriptomic divergence between two European terrestrial orchids, Dactylorhiza incarnata and Dactylorhiza fuchsii, and integrate these results in the context of their distinct ecologies that we also document. Clear signals of lineag
Stress corrosion experiments were performed on unidirectional ECR-glass/polymer composites with the modified polyester, epoxy and vinyl ester resins for the use in high voltage composite insulator applications. Two types of ECR-glass fibers were investigated with low and high counts of gaseous inclusions (seeds) within the glass. The stress corrosion tests were performed in nitric acid under four
Aim: Analysis of age at time of detection and surgery of dense unilateral cataract and investigation of best-corrected visual acuity (BCVA) in a nationwide register-based cohort study, based on the routine of maternity ward eye screening. Methods: Data were derived from the Paediatric Cataract Register (PECARE). All children (n = 54) diagnosed with dense congenital unilateral cataract between Janu
The healthy cornea is transparent, however, disease can affect its structure, rendering it more or less opaque. The ability to assess the clarity of the cornea objectively could thus be of considerable interest for keratoconus patients. It has previously been suggested that densitometry can be used to diagnose early keratoconus, and that the values of densitometry variables increase with increasin
In both the US and EU, policymakers and government agencies are acknowledging theimportance of having access to repair options, particularly for vulnerable product users who depend on their products. As such, repair can play an important role as a resource for resilience, but research is missing. We propose that repair can act as a resource for resilience. A comprehensive, structured way to unders
This collection gathers the more important instruments dealing with the relationships of business with a range of topics such as labor rights, security issues, environmental protection, anti-corruption, good governance, poverty alleviation and development, which all have important human rights dimensions. The premise for this selection is that business has both responsibilities and opportunities t
In addition to its well-known hematopoietic effects, erythropoietin (EPO) also has neuroprotective properties. However, hematopoietic side effects are unwanted for neuroprotection, underlining the need for EPO-like compounds with selective neuroprotective actions. One such compound, devoid of hematopoietic bioactivity, is the chemically modified, EPO-derivative carbamylerythropoietin (CEPO). For c
Background: SARS-CoV-2 mRNA vaccination has been associated with both side effects and a reduction in COVID-related complaints due to the decrease in COVID-19 incidence. We aimed to investigate if individuals who received three doses of SARS-CoV-2 mRNA vaccines had a lower incidence of (a) medical complaints and (b) COVID-19-related medical complaints, both as seen in primary care, when compared t
