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C-Kit as an Oncogenic Tyrosine Kinase - Regulation and Dysregulation of Signaling Pathways

It is well known that increased growth and survival of cancer cells often is a result of dysregulated kinase activity and aberrant kinase signaling. The receptor tyrosine kinase c-Kit and its ligand SCF are contributors to this phenomenon in a variety of human cancers, for example hematological malignancies, germ cell tumors and gastrointestinal stromal tumors. In this thesis I have investigated

Engångs- eller returtransportförpackningar i livsmedelsbutiker

Master thesis for Mechanical engineering, at the University of Lund. Incorporated in project Pondora. The purpose of this master thesis is to compare the existing one way packaging system with a proposed return crate system not yet available in Sweden. The comparison is focused on packaging handling in the grocery store. The purpose is also to investigate how operating return crate systems in No

Clinical course of early onset prostate cancer with special reference to family history as a prognostic factor

OBJECTIVE: The aim of this study was to describe the clinical characteristics of early onset prostate cancer, with special reference to family history as a possible prognostic factor.MATERIAL AND METHODS: We identified all cases of prostate cancer diagnosed before the age of 51 in the Southern health care region in Sweden between 1958 and 1994. Clinical data were collected retrospectively from med

Manganese concentrations in drinking water from villages near banana plantations with aerial mancozeb spraying in Costa Rica : Results from the Infants' Environmental Health Study (ISA)

Elevated manganese (Mn) in drinking water has been reported worldwide. While, naturally occurring Mn in groundwater is generally the major source, anthropogenic contamination by Mn-containing fungicides such as mancozeb may also occur. The main objective of this study was to examine factors associated with Mn and ethylenethiourea (ETU), a degradation product of mancozeb, in drinking water samples

Comparing thermal performance curves across traits : how consistent are they?

Thermal performance curves (TPCs) are intended to approximate the relationship between temperature and fitness, and are commonly integrated into species distributional models for understanding climate change responses. However, TPCs may vary across traits because selection and environmental sensitivity (plasticity) differ across traits or because the timing and duration of the temperature exposure

The Russia-Ukraine conflict : its implications for the global food supply chains

Food is one of the most traded goods, and the conflict in Ukraine, one of the European breadbaskets, has triggered a significant additional disruption in the global food supply chains after the COVID-19 impact. The disruption to food output, supply chains, availability, and affordability could have a long-standing impact. As a result, the availability and supply of a wide range of food raw materia

Simplified environmental analysis of the long-term performance of wood cladding and decking

The performance of timber in exposed environments is affected by several biotic and abiotic factors. For timber cladding and decking, two important aspects include reduced structural performance due to fungal decay and aesthetical changes resulting from superficial effects such as photodegradation and moulds. Predicting the long-term performance of timber is important because it enables rational m

Soil Microbial Responses to 28 Years of Nutrient Fertilization in a Subarctic Heath

Arctic and subarctic soils are typically characterized by low nitrogen (N) availability, suggesting N-limitation of plants and soil microorganisms. Climate warming will stimulate the decomposition of organic matter, resulting in an increase in soil nutrient availability. However, it remains unclear how soil microorganisms in N-limited soils will respond, as the direct effect of inorganic N additio

P2Y12 receptor inhibitors in patients with non-STelevation acute coronary syndrome in the real world : Use, patient selection, and outcomes from contemporary European registries

Aims Non-ST-elevation acute coronary syndrome (NSTE-ACS) is present in about 60-70% of patients admitted with acute coronary syndromes in clinical practice. This study provides a 'real-life' overview of NSTE-ACS patient characteristics, dual antiplatelet therapy clinical practice, and outcomes at both the time of discharge from hospital and up to 1-year post-discharge. Methods and results A total

Outlining recent updates on influenza therapeutics and vaccines : A comprehensive review

Influenza virus has presented a considerable healthcare challenge during the past years, particularly in vulnerable groups with compromised immune systems. Therapeutics and vaccination have always been in research annals since the spread of influenza. Efforts have been going on to develop an antiviral therapeutic approach that could assist in better disease management and reduce the overall diseas

Descriptive Analysis of Sensory Properties of Wet-Boiled Peanut Sauce : The Effect of Boiling Time and the Presence of Kernel Coating

Descriptive sensory analysis was used to characterize the flavor changes of peanuts during boiling. The attributes investigated were rawness, astringency, and bitterness. Samples of peanut sauce prepared with seed coating and without seed coating and taken at different cooking times (1, 15, 30, 60, 90, and 120 min) were compared. A descriptive panel (N = 16 peanuts with coating and N = 17 peanu

The Versatile Touchpoint : User-Generated Content Reshaping the Customer Journey

The Versatile Touchpoint: User-Generated Content Reshaping theCustomer JourneyAUTHORS1, Affiliation; 2, Affiliation; 3, Affiliation; 4. AffiliationKeywordsIntroductionCustomer Journey; User Generated Content; Social Media; Touchpoint; Brand PublicsIn this study we seek to unravel the emergence of a touchpoint that has become ubiquitousthroughout the customer journey due to social media. We are esp

Cross-generational transmission of genetic risk for alcohol and drug use disorders : the impact of substance availability on the specificity of genetic risk

Background Among individuals with alcohol use disorder (AUD) and drug use disorder (DUD), is their genetic liability and its specificity moderated by substance availability? Methods Offspring (born 1960-1995) and their biological parents from three family types [not-lived-with (NLW) biological father, mother and adoptive] and their AUD and DUD diagnoses were ascertained from Swedish national regis

Pharmaceutical Manufacturer Strategies to Parallel Importation in the EU: A Strategic Update in Light of European Court of Justice Rulings

Problem: Parallel trade occurs when a product is released on one market, and an importer purchases the product in question on a lower priced market, and subsequently imports the product to a higher priced market, and sells it there. Parallel trade of pharmaceuticals in the European Union is prevalent since the legal, business and political environment makes the trade relatively easy and legal. Thi

Investigating the business opportunities and impact of cloud technology a case study on maritime industry

Background: New technologies and innovations have the power to swiftly disrupt complete industries across the globe. This puts pressure on companies to understand how new technologies could change future product offerings and impact the business model. Purpose: The purpose of this study is to provide an example of how new technology will generate new business models. This study is done as a case s

On the reporting of production performance in a global operation

As companies compete on the global market with an increasing amount of competitors trying to win market shares the need for an increasingly effective production becomes apparent. By utilizing the correct indicators the company can identify and improve their weaknesses to becoming more effective. The project is performed at five of Alfa Laval’s production sites, 1, 2, 3, 4 and 5. The study is also

Shopping for a better world - whether supply chain transparency can assure clarity within the pursuit of goods untainted by intolerable practices

As legislators in recent years have adopted regulations demanding companies to disclose information on their supply chains, a new chapter of corporate transparency has been opened. However, what power such regulations have to initiate a change of corporate behaviour is questionable. In this thesis the most topical of the recently adopted supply chain transparency and due diligence regulations, are

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Course analysis – Analysis in one variable, MATA21 / ÄMAD01 HT21 Lecturer: Jan-Fredrik Olsen (first half), Eskil Rydhe (second half). Seminar teachers: Alex Bergman, Frej Weiström Dahlin (second half), Joakim Cronvall (first half), Jonathan Holmquist (second half). Summary: The ongoing pandemic has required large adaptations of the practical aspects of teaching and examination. Students rank sta

https://www.maths.lu.se/fileadmin/maths/Matematik_NF/Kursutvaerderingar/HT2021/MATA21AEMAD01HT21.pdf - 2026-05-21

Masterutbildning i livsmedelssystemanalys utbildningsplan

Masterutbildning i livsmedelssystemanalys utbildningsplan Sida 1 av 8 Utbildningsplan Masterutbildning i livsmedelssystemanalys - Programkod: TALSA - Omfattning: 120 högskolepoäng - Tillträdesnivå: Avancerad nivå - Beslutsfattare: Carl Grey - Utbildningsplanens giltighet: 2025/2026 - Utbildningsplanen fastställd: 2025-02-13 1 Syfte och mål 1.1 Syfte Målet med MFS-programmet är att förbereda studen

https://www.student.lth.se/fileadmin/lth/student/Utbildningsplaner_2023_och_fram/Master_svenska/25_26/Utbildningsplan_Masterutbildning_i_livsmedelssystemanalys_25-26.pdf - 2026-05-21