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The process of population ageing that has been occurring in Sweden can be expected to continue during the coming decades, the population pyramid will become increasingly rectangular, and possibly even demonstrating a shrinking base. This will lead to increasing challenges in terms of financing pensions, elderly care and healtcare. These problems will continue for at least 30 years with no demograp
Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic predisposition to the disease may be different in lean (BMI<25 Kg/m(2)) compared to obese cases (BMI >= 30 Kg/m(2)). We performed two case-control genome-wide studies using two accepted cut-o
Acquired chromosome abnormalities in tumours often reflect pathogenetic events at the gene level. Multicolour fluorescence in situ hybridisation (FISH) with single-copy probes offers extensive possibilities to characterise chromosome breakpoints in relation to the physical map of the human genome. This approach is based on the construction of comprehensive EST- based maps, combinatorial labelling
The presence of a functional glpT gene in Haemophilus influenzae could be questioned, since there is only what appears to be a truncated glpT (HI0686, 143 nt in the 5'-end) available in the H. influenzae Rd genome database (Fleischmann et al. , 1995). For cloning of the glpT gene from H. influenzae type b strain Eagan, an isogenic glpT, rec-1 double mutant and a selective medium for detection of t
Popular Abstract in Swedish Polycykliska aromatiska kolväten (PAH) är en grupp organiska ämnen som kan vara giftiga men även starkt cancerframkallande. De bildas vid förbränning av organiskt material vid låg syretillförsel och återfinns i olika produkter som tjära och fossila bränslen. De källor som tillför störst mängd till miljön idag är bostadsuppvärmning med ved, kol och olja (i Sverige ca 2/3Polycyclic aromatic hydrocarbons (PAHs) are a group of organic pollutants of great environmental concern, due to their toxicity, carcinogenicity and long persistence in the environment. To determine the potential risk associated with PAHs released from contaminated soil or waste materials, knowledge is required on the leachable concentrations of PAHs and the amounts available for release. The obj
There is an ongoing trend towards higher automation level in process control systems. The purpose of a plant is to manufacture some product at a high production rate with a consistent quality, while minimizing the use of resources in terms of energy consumption, raw material and labor. With a higher degree of autonomy in the control system, it is possible to improve all these aspects, thus increas
PURPOSE Cardiovascular disease (CVD) is a potential adverse effect of endocrine treatment (ET) for prostate cancer (PC). We investigated absolute and relative CVD risk in 76,600 patients with PC undergoing ET, curative treatment, or surveillance. METHODS PCBaSe Sweden is based on the National Prostate Cancer Register, which covers more than 96% of PC cases. Standardized incidence ratios (SIRs) and
I investigated the bacterial utilization of terrestrially derived dissolved organic nitrogen (DON) in aquatic ecosystems, and assessed the potential role of river-born DON in marine eutrophication. To determine the bioavailability of DON, I developed a bioassay employing N-limited bacterial regrowth cultures, which were calibrated with additions of inorganic nitrogen. I found that between 2 and 72
Context: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are cleaved by dipeptidyl peptidase-4 (DPP-4); plasma activity of DPP-4 may be increased in obesity. The impact of this increase on incretin hormone secretion and metabolism is not known. Objective: The aim of the study was to assess incretin hormone secretion and degradation in lean and obese nondiabet
ObjectiveSputum cultures can guide antibiotic therapy, particularly in severe pneumonia or when resistant pathogens are suspected. However, data on how prior and ongoing antibiotic exposure affects microbial detection are limited. This study aimed to evaluate this impact, stratified by timing and route of administration.MethodsIn- and outpatients from nine hospitals in Skåne, Sweden, who submitted
Commercial bean products were studied in terms of chemical composition and starch digestibility. In general, commercial cooked flours did not show differences in protein and ash contents. Canned beans also did not show statistical differences (α=0.05) in protein, but they were different in ash, perhaps due to botanical variety. Lipid content varied in the different flours, due to the formulation u
INTRODUCTION: Differences in treatment and outcome have been reported for persons with haemophilia (PWH) on intermediate-dose (Dutch) and high-dose (Swedish) prophylaxis, but the potential influence of sports participation has not been considered.AIM: To compare sports participation and clinical outcome between adult Dutch and Swedish PWH.METHODS: Self-reported sports participation (type and frequ
2017%20LUMES%20THESIS%20SCHEDULE%2029-31%20May%20to%20discussants%20%20examiners%20%20students%20May%2017.pdf LUMES 2015-2017 Thesis Seminar Schedule Monday 29, Tuesday 30, and Wednesday 31May 2017 MONDAY 29 May 2017 in Wrangel Time 29/5 Venue Examiner Respondent Thesis Title Discussant Supervisor 8.15 - 9.15 Library Lennart Olsson Louis Eberstål We cannot love nature to death. An evaluation of th
https://www.lumes.lu.se/sites/lumes.lu.se/files/thesis_defenses_schedule_2017.pdf - 2026-05-30
This thesis reports the work done in the development of a modified Lean Premix Prevaporised (LPP) burner for the use in Alstom Power Sweden’s industrial gas turbines. Incentive for the development of the modified burner have been the need to increase the flame stability over the operating range for the burner, especially for the liquid fuel but also the gaseous fuel operation. Foundation for modif
AIMS/HYPOTHESIS: The aim of this work was to explore molecular amino acids (AAs) and related structures of HLA-DQA1-DQB1 that underlie its contribution to the progression from stages 1 or 2 to stage 3 type 1 diabetes.METHODS: Using high-resolution DQA1 and DQB1 genotypes from 1216 participants in the Diabetes Prevention Trial-Type 1 and the Diabetes Prevention Trial, we applied hierarchically orga
Para Alpine skiing is one of the largest sports at the Paralympic Winter Games. Recent studies report high injury rates in this sport. However, limited evidence exists regarding sport-specific injury characteristics, which is essential for targeted prevention. The aim of this study was to describe the overall incidence proportion and incidence of injuries reported by athletes participating in Alpi
In Sweden, the adoption of membrane technology for drinking water production is increasing, prompting many water producers to consider substantial investments in new membrane facilities. Ensuring the sustainability of membrane operation in terms of cost,environmental impact, and long-term performance is a top priority. This descriptive study aims to identify common operational trends or practices
Den torkdrabbade Östra provinsen i Rwanda upplever återkommande vattenbrist som begränsar befolkningens försörjningsmöjligheter. Denna studie undersöker säsongsvariationer i vattenanvändning, tillgång och effekter av vattenbrist i Lower Akagera-området genom en kombination av hushållsintervjuer, grundvattenövervakning och fjärranalys av dammar. Ett Normaliserat Vattenanvändningsindex utvecklThe drought-prone Eastern Province of Rwanda faces recurring water scarcity that constrains rural livelihoods. This thesis investigates seasonal water use, availability, and impacts in the Lower Akagera catchment by combining household interviews, groundwater monitoring, and remote sensing of dams. A Normalised Water Use Index (NWUI) was developed to capture seasonal groundwater abstraction and l
Moisture plays a central role in the performance of wood products because it affects important material properties such as the resistance to decomposition, the mechanical properties, and the dimensions. To improve wood performance, a wide range of wood modification techniques that alter the wood chemistry in various ways have been described in the literature. Typically, these modifications aim to
Arsenic (As) is one of the most important dangerous elements as more than 100 million of people are exposed to risk, globally. The permissible threshold of As for drinking water is 10 μg/L according to both the WHO’s drinking water guidelines and the Iranian national standard. However, several studies have indicated that As concentrations exceed this threshold value in several regions of Iran. Thi
