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The importance of carbohydrates in biological systems has become evident during the last fifty years. It is well known that pathogenic bacteria and viruses attach to glycoconjugates present at mammalian cell surfaces, and that this attachment is a prerequisite for the later stages of infection. Obviously, this interaction is interesting as a target for the development of novel ways to treat bacter
Purpose: To estimate inter-observer agreement with regard to describing adnexal masses using the International Ovarian Tumor Analysis (IOTA) terminology and the risk of malignancy calculated using IOTA logistic regression models LR1 and LR2, and to elucidate what explained the largest inter-observer differences in calculated risk of malignancy. Experimental Design: 117 women with adnexal masses we
Abstract Determination of the respiratory tract deposition of airborne particles is critical for risk assessment of air pollution, inhaled drug delivery, and understanding of respiratory disease. With the advent of nanotechnology, there has been an increasing interest in the measurement of pulmonary deposition of nanoparticles because of their unique properties in inhalation toxicology and medicin
During embryonic development and adult life a wide range of cell behaviors such as differentiation, proliferation and migration are in effect to maintain tissue integrity and function. An integral part of these dynamic processes is the interplay between the cells and their environment, i.e. the extracellular space. Complex polysaccharides, such as dermatan sulfate play a key role in these processe
Objective The purpose of this study was to evaluate the effect of wet clothing removal or the addition of a vapor barrier in shivering subjects exposed to a cold environment with only limited insulation available. Methods Volunteer subjects (n = 8) wearing wet clothing were positioned on a spineboard in a climatic chamber (–18.5°C) and subjected to an initial 20 minutes of cooling followed by 3
BACKGROUND: Female sex pheromones attracting mating partners over long distances are a major determinant of reproductive isolation and speciation in Lepidoptera. Males can also produce sex pheromones but their study, particularly in butterflies, has received little attention. A detailed comparison of sex pheromones in male butterflies with those of female moths would reveal patterns of conservatio
OBJECTIVE: To compare the reliability of quantitative measurement of minimum hip joint space with a qualitative global assessment of radiological features for estimating the prevalence of primary osteoarthritis (OA) of the hip in colon radiographs.METHODS: All colon radiographs from patients aged 35 or older, taken at three different radiographic departments in Iceland during the years 1990-96, we
Background: Levodopa–carbidopa intestinal gel (LCIG) is available in several countries for the treatment of advanced levodopa-responsive Parkinson’s disease (PD) with severe motor fluctuations and dyskinesia when other treatments have not given satisfactory results. Objective: Our objective was to summarize the present evidence base for LCIG therapy through a systematic review of the literature. M
Background: Concomitant Alzheimer's disease (AD) pathology is observed in Lewy body diseases (LBD), but the clinical impact is unknown. Only a few biomarker studies in LBD exist and have included small cohorts from single centers. Objective: We aimed to evaluate the prevalence of abnormal cerebrospinal fluid (CSF) AD biomarkers across the spectrum of LBD in a large multicenter cohort and to assess
OBJECTIVE: Patients with non-muscle-invasive bladder cancer are traditionally followed by repeat cystoscopy and urine cytology. A fluorescence in situ hybridisation technique called UroVysion((R)) (UV) is now available for clinical diagnosis of urothelial cancer cells. The aim of the present study was to compare UV analysis with routine follow-up methods. METHODS: We studied an unselected cohort o
Analysis of in situ and satellite data shows evidence of different regional snow cover responses to the widespread warming and increasing winter precipitation that has characterized the Arctic climate for the past 40-50 years. The largest and most rapid decreases in snow water equivalent (SWE) and snow cover duration (SCD) are observed over maritime regions of the Arctic with the highest precipita
I ett aktiebolag eller motsvarande bolagsform med begränsat ansvar för aktieägarna står aktiekapitalet i centrum. Lagstadgat krav på aktiekapital har förekommit i somliga rättsordningar. I vissa länder har kapitalkravet eftergetts. I detta arbete kommer att göras en komparativ jämförelse mellan Tysklands, Storbritanniens, Sveriges och EU:s aktiebolagsformer med avseende på minsta kapitalkravet i bIn a limited liability company or similar corporate form with limited liability for the shareholders the legal capital plays an important role. The minimum capital requirements have appeared in some jurisdictions. In some countries, the minimum capital requirement have been abolished. This work will be a comparative comparison between German, British and Swedish companies rules with focus on the m
Recently the question of agriculture development has been emphasised as an important part of balanced sustainable growth in China. My paper accounts for different growth trajectories and development pace between coastal regions and inland provinces. My interest is more convergence-divergence between agriculture development in different regions than convergence-divergence between rural and urban ar
For the Geneva motor show 2006 I created a special Trim and Colour for Pininfarina’s three production cars. Trim and Colour means the complete design of materials and colours used in the car exterior and interior. In my diploma work I explored the possibility to unite the image of three different cars by the use of material and colours. I analysed the exhibition environment in which they were to
Abstract Since the late 1970’s, China has rapidly increased its exports of industrial products and inflow of foreign direct investment (FDI) through the use of special economic areas (SEA), which offer special benefits to foreign investors and export producers. Common criticism against these SEAs, usually states that these areas show persistent low-standard working conditions and wages to remain c
Kristianstadsslätten breder ut sig i nordöstra Skåne och in i sydvästra Blekinge med sin komplicerade och varierade geologi. De komplexa förhållandena leder till att det finns ett flertal akvifärer i både jordlager och berggrund, där den mest vattenförande formationen är den av glaukonitsand. Syftet med arbetet har varit att undersöka vilket infiltrerat vattenflöde, vid vilket pumptryck, en brunn Kristianstad plain stretches from the northeast of Scania to the southwest of Blekinge with a complicated and varying geology. The complexity has resulted in multiple aquifers in both soil and bedrock, where the highest amount of withdrawable groundwater is in the formation of glauconite sand. The aim of this paper has been to investigate which infiltrated water flow at a certain pumping pressure,
Summary: Chronic critical lower limb ischemia (CLI) has been defined as ischemia that endangers the leg. An attempt was made to give a precise definition of CLI, based on clinical and hemodynamic data (Second European Consensus). CLI may be easily defined from a clinical point of view as rest pain of the distal foot or gangrene or ulceration. It is probably useful to add leg ulcers of other origin
X-ray crystallography is the main source of atomistic information on the structure of proteins. Normal crystal structures are obtained as a compromise between the X-ray scattering data and a set of empirical restraints that ensure chemically reasonable bond lengths and angles. However, such restraints are not always available or accurate for nonstandard parts of the structure, for example substrat
Healthcare workers (HCWs) were the first population group offered coronavirus disease 2019 (COVID-19) vaccines in South Africa because they were considered to be at higher risk of infection and required protecting as they were a critical resource to the health system. In some contexts, vaccine uptake among HCWs has been slow, with several studies citing persistent concerns about vaccine safety and
Prostate-specific antigen (PSA) has been the main drive for early detection of prostate cancer (PCa), including in population-based screening as in the European Randomised Study for Screening of Prostate Cancer (ERSPC). The specificity of PSA to indicate men with biopsy detectable prostate cancer can be improved by adding information obtained by new biomarkers, such as PSA isoforms. This improveme
