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Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,
AIMS: In the era of genome-wide association studies, familial risks are used to estimate disease heritability and success in gene identification. We wanted to estimate associations of 42 autoimmune diseases with attention-deficit hyperactivity disorder (ADHD) between individuals and family members.PARTICIPANTS AND METHODS: The availability of a Multigeneration Register in Sweden provides reliable
Two studies were conducted to investigate the role of meat and arachidonic acid in colonie signal transduction, particularly protein kinase C (PKC) activation. In Study 1, 26 male Wistar rats were fed a casein‐ or a beef‐based diet for four weeks. PKC activity was measured from the proximal and distal colonie mucosa and diacylglycerol concentration from fecal samples. The beef diet significantly i
Exopolysaccharides (EPSs) produced by the lactic acid bacteria (LAB) Lactococcus lactis and Streptococcus thermophilus are important for the rheological behaviour and texture of a variety of fermented food products. Furthermore, EPSs from food-grade LAB have potential as food additives and functional food ingredients with both health and economic benefits. However, the production lev
This paper looks at the place of heritage in city branding in China and the different discourses and narratives found in city promotional films and independent documentary films. A city’s character is shaped by its history. All the different cultural, social and historical events that have taken place in the city inform its identity and urban form, as manifested in monuments and buildings from di
Chapter 2 analyses the relationship between capital structure and industry classification of Swedish firms. This study also analyses the determinants of the capital structure at the industry level. Since the assumption required for a parametric analysis of variances are not satisfied, a nonparametric method is applied to test for cross-industry differences in capital structure. The results show th
We examined the association between self-reported consumption of fruits and vegetables and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Data on food consumption and complete follow-up for cancer incidence were available for 130,544 men in 7 countries recruited into EPIC between 1993 and 1999. After an average of 4.8 years of follow-up, there were
Homografts have long been used for right ventricular outflow tract (RVOT) reconstruction. Tissue banks struggle to meet the clinical demand of tissue, with insufficient donor availability and strict recommendations on tissue quality with high proportions of discards. This study analyzes the long-term outcome of patients receiving a homograft with small fenestrations of the cusps or other structura
Background: Uncomplicated cystitis is one of the most common reasons for antibiotic treatment in otherwise healthy women. Nationwide studies on antibiotic treatment for this infection and in relation to factors beyond the infection itself have hitherto not been available. Methods: This was a nationwide open cohort study consisting of 352,507 women aged 15–50 years with uncomplicated cystitis (2006
The accurate evaluation of shifts in vegetation phenology is essential for understanding of vegetation responses to climate change. Remote-sensing vegetation index (VI) products with multi-day scales have been widely used for phenology trend estimation. VI composites should be interpolated into a daily scale for extracting phenological metrics, which may not fully capture daily vegetation growth,
Ceramic biomaterials are promising alternatives to bone autografts. However, limited bioactivity affects their performance. Therefore, bioactive molecules and cells are often added to enhance their performance. Exosomes have emerged as cell-secreted vesicles, delivering proteins, lipids, and nucleic acids in a paracrine/endocrine fashion. We studied two complementary aspects required for exosome a
The energy balance at most surface-atmosphere flux research sites remains unclosed. The mechanisms underlying the discrepancy between measured energy inputs and outputs across the global FLUXNET tower network are still under debate. Recent reviews have identified exchange processes and turbulent motions at large spatial and temporal scales in heterogeneous landscapes as the primary cause of the la
We report the clinical feasibility of fluoroscopic Roentgen stereophotogrammetric analysis (FRSA), a validated method to quantify, real time three-dimensional (3D) dynamic motion of stent grafts and the first clinical results after abdominal and thoracic endovascular repair (EVAR). Stent graft motion was measured at 30 (stereo) frames per second, during the cardiac cycle and in the patient after a
Both high-mountain rivers and wet-based mountain glaciers are considered effective erosion agents. They acted alternatively or simultaneously during the late Quaternary in the Tatra Mountains (West Carpathians) thus producing a vast amount of clastic material that was subject to deposition, reworking and transportation downstream. A small fraction of that amount of the material is still preserved
Den här rapporten redovisar det arbete som utförts av Andreas Byström och Josefin Salomonsson inom ramen för civilingenjörsprogrammets examensarbete. Arbetet har utförts på Scania, avdelningen för specialfordon från november 2009 till april 2010. Scania har en lång bakgrund som leverantör av militära fordon till försvarsmakter världen över. Scanias militära lastbilar är uppbyggda av samma grundstThis report is a result of a Master Thesis project in mechanical engineering by Andreas Byström and Josefin Salomonsson. The thesis was carried out at Scania CV AB at the department for Special Vehicles and the Division of Machine Design at the Department of Design Science at LTH from November 2009 to April 2010. Scania has a long tradition of designing and deliver vehicles to national defence fo
Inborn errors of metabolism are genetic disorders that need to be recognized as early as possible because treatment may be available. In late-onset forms, core symptoms are movement disorders, psychiatric symptoms, and cognitive impairment. Eye movement disorders are considered to be frequent too, although specific knowledge is lacking. We describe and analyze eye movements in patients with an inb
Ongoing and future climate change will affect our built environment. It will have an impact on how we should design our structures to withstand the future environment. One important load when designing buildings in high latitudes and high elevations is the snow load, which in many countries is the governing load for roofs and other structural parts. A warmer climate may lead to a reduction in snow
The technological evolution and widespread availability of wearables and handheld ECG devices capable of screening for atrial fibrillation (AF), and their promotion directly to consumers, has focused attention of health care professionals and patient organizations on consumer-led AF screening. In this Frontiers review, members of the AF-SCREEN International Collaboration provide a critical apprais
Doctoral education in the technical fields has several distinct features, such as, the research is often projectbased, interdisciplinary, dependent on external funding, and affiliated with an industry. In other words, the epitome of a “modern doctorate” (Fillery-Travis, 2017; Lee, 2018). While literature on doctoral supervision in general is abundant (see e.g. Gatfield, 2005; Gurr, 2001; Ives &
