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The outcome of management of diabetic foot ulcers is poor and there is uncertainty concerning optimal approaches to management. We have undertaken a systematic review to identify interventions for which there is evidence of effectiveness. A search was made for reports of the effectiveness of interventions assessed in terms of healing, ulcer area or amputation in controlled clinical studies publish
OBJECTIVE: To assess the risk of over-diagnosing and over-treating prostate cancer if population-based screening with serum prostate-specific antigen (PSA) is instituted. PATIENTS AND METHODS: From a serum bank stored in 1980, PSA was analysed in 658 men with no previously known prostate cancer from a well-defined cohort from Goteborg, Sweden (men born in 1913); the incidence of clinical prostate
Popular Abstract in Swedish Avhandlingen består av tre separata papper. De är alla empiriska studier som undersöker hur fragmentering av produktionsprocesser och globala utbudskedjor har påverkat internationell handel. Den första studien fokuserar på hur privata standarder i den alltmer globaliserade livsmedelsindustrin påverkar företags importbeteende. Genom att ge en kvalitetsförsäkran kan cerThis thesis consists of three separate papers. They are all empirical papers that examine how fragmentation of production processes and global value chains have affected international trade patterns. The first paper focuses on how private standards in the increasingly geographically fragmented food sector affect firm-import behaviour. By providing a quality insurance for the imported good, certi
In order to reduce parasite-induced mortality, hosts may be involved in mutualistic interactions in which the partner contributes to resistance against the parasite. The pea aphid, Acyrthosiphon pisum Harris (Hemiptera: Aphididae), harbours secondary bacterial endosymbionts, some of which have been reported to confer resistance against aphid parasitoids. Although this resistance often results in d
The structure, biosynthesis, and metabolism of proteoglycans in the HL-60 human promyelocytes were studied by metabolic labeling in culture with [35S]sulfate, [3H]glucosamine, [3H]serine, and [3H]leucine. These cells synthesize a single predominant species of intracellular proteoglycan with an approximate molecular weight of 100,000. The cells contain about 1 μg of proteoglycan/million cells. The
Background and Purpose: Although reirradiation of glioblastoma has a long history of clinical practice, guidance on how to perform it in the context of recent technological advances, modern imaging modalities or systemic therapy is scarce. This joint ESTRO/EANO guideline aims to collect the existing evidence to produce recommendations for safe reirradiation of glioblastoma. Methods: The basis of t
Low-dimensional topological states have transformed our understanding of charge transportation through quantum materials. Many relevant observations have been connected to bismuth (Bi) containing materials or ultrathin Bi films. Here, we studied sub-monolayer amounts of Bi deposition on the In-terminated InSb(111)A surface using various complementary surface science techniques. Bi deposition at el
First Infant Formula Type and Risk of Islet Autoimmunity in The Environmental Determinants of Diabetes in the Young (TEDDY) Study First Infant Formula Type and Risk of Islet Autoimmunity in The Environmental Determinants of Diabetes in the Young (TEDDY) Study DOI: 10.2337/dc16-1624 OBJECTIVE Studies on the introduction of infant formulas and its effect on the risk of islet autoimmunity and type 1
https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/63%2001252019_679_063_MP102_HummelS_Diab%20Care_2017.pdf - 2026-07-17
Att säkra tillgång till patentskyddade medicinska produkter, särskilt livsnödvändiga läkemedel rörande HIV/AIDS och andra epidemiska sjukdomar, har varit i fokus för en global juridisk debatt under många år. Denna debatt intensifierades ytterligare efter tillkomsten av TRIPS-avtalet och den globala verkställigheten av immaterialrätter såsom patent genom Världshandelsorganisationen (WTO). Många NThe issue of securing access to patented pharmaceutical products, especially essential medicines in the field of HIV/AIDS and other epidemic diseases, has been in the forefront of global legal debate for many years. This debate intensified further following the enactment of the TRIPS agreement and the global enforcement of Intellectual Property Rights such as patents through the World Trade Organi
Political analyses of the reform period China are plentiful, and for each analysis, there seems to be another version of a “China Model” or “Beijing Consensus” for economic and social development. This paper argues that these vague conceptualizations need to be rooted in empirical observations; they need to be products of induction rather than deductive processes that reiterate the preconceptions
The production of TMP (Trimethylolpropane) is important for many applications, and is used as alkyds in paint and lubricants among others. The reactions producing TMP consist of two major reaction chains, Aldol condensation and Cannizzaro reaction. To get a deeper understanding and improve the running conditions the kinetic expressions for the reactions were examined. The aim of this paper was to
The traditional art market is currently experiencing a digital transformation and multi-sided platforms (MSPs) for trading art are a major part of this. Much research has been done in the area of MSPs, however, there is a lack of studies in the field of starting such platforms for art. Therefore, this study aims to determine the critical success factors (CSFs) for starting an online art platform (
Iron is a micronutrient that a lot of people all over the world lack to some extent. Researching new ways to enrich food may be a part of the future food industry. One way is to enrich the crops we grow. Hence, with the help of ascorbic acid as a pH adjustor and ironcitrate, tries have been made to enrich alfalfa sprouts. Sprouting as a method is also a good way to break down antinutrients in seed
I mogna industrier prioriteras ofta verkningsgrad och processen snarare än själva produkten. Detta innebär att dessa industrier anpassar sig långsamt när de externa förhållandena skiftar. Exempel på sådan industri är Sveriges köttindustri. Denna präglas av stor klimatpåverkan, även stora mängder matsvinn. Nya teknologier undersökes i nuläget för att skärpa detta svinn; exempel på sådan teknologi äThe competitive landscape mature industries find themselves in tends to make them enforce practices that ruthlessly focus on efficiency and process. This narrow focus makes them slow to adapt to changes in the external environment in which they operate. One such case is the Swedish meat industry. Like many industries, there are downsides involved with meat production and for meat a significant one
Microbial decomposition of soil organic matter (SOM) is the source of most of the terrestrial carbon dioxide emission. Consequently, our ability to predict how climate warming will affect the global carbon (C) budget relies on our understanding of the temperature relationship and adaptability of microbial processes. We exposed soil microcosms to temperatures between 0 and 54 degrees C for 2 months
Environmental change may affect predator-prey interactions in lakes through deterioration of visual conditions affecting foraging success of visually oriented predators. Environmental change in lakes includes an increase in humic matter causing browner water and reduced visibility, affecting the behavioural performance of both piscivores and prey. We studied diurnal patterns of prey selection in p
Software failures in medical devices can lead to catastrophic situations. Therefore, it is crucial to handle software-related risks when developing medical devices, and there is a need for further analysis of how this type of risk management should be conducted. The objective of this paper is to collect and summarise experiences from conducting risk management with an organisation developing medic
OBJECTIVE: To evaluate the outcome of patients with suspected normal pressure hydrocephalus at 6 months and 5 years after shunt Surgery. METHODS: Seventy-five patients (mean age, 72.5 +/- 9 yr), with normal pressure hydrocephalus symptoms were included. Fifty-four patients with positive lumbar infusion and/or cerebrospinal fluid tap tests received a cerebrospinal fluid shunt, whereas 21 patients w
Concrete is the most widely used construction material worldwide, with an annual global consumption of approximately 30 billion tons and 14–15 million tons in Sweden in 2022. Its popularity stems from its durability, robustness, formability, and resistance to moisture, mold,fire, and sound. However, concrete production has a significant environmental impact, largely due to cement manufacturing, wh
