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Lung function is highly dependent on the structure of the lung parenchyma. Remodeling of the alveolar compartment is a central part of the pathology of chronic lung disease such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). Pathological lung remodeling occurs as an interplay between cells and the extracellular matrix (ECM) which in addition to its structu
X-ray diffraction methods have been used to study the crystal structure of different compounds, both organic and inorganic. The inorganic compounds were all synthesized by solid state reactions. A new compound, Re4As6S3, was synthesized and its structure was solved by Rietveld methods. Re4As6S3 is a cluster compound described by a
As current silicon-based microelectronic devices and circuits are approaching their fundamental limits, the research field of nanoelectronics is emerging worldwide. With this background, the present thesis focuses on semiconductor nanoelectronic devices based on ballistic and quantum effects.
The main material studied was a modulation doped In0.75Ga0.25As/InP semiconductor two-dimensional el
This thesis focuses on collaboration in interorganizational implementation processes carried out in temporary organizations. Due to the increased level of collaboration in logistics, interorganizational implementation projects are becoming increasingly important. Consequently, for companies to stay competitive from a logistical point of view, interorganizational relationships need to be addressed.
Exposure to Ljungan virus (LV) is implicated in the risk of autoimmune (type 1) diabetes but possible contribution by other parechoviruses is not ruled out. The aim was to compare children diagnosed with type 1 diabetes in 2005-2011 (n = 69) with healthy controls (n = 294), all from the Jämtland County in Sweden, using an exploratory suspension multiplex immunoassay for IgM and IgG against 26 pept
The paper analyses the legal framework for the collection and distribution of remote sensing data, particularly in the field of sustainable development and environmental protection at the European level. The research firstly focuses on the historical evolution of space law at the international, European, and national levels, starting from the 1970s. In parallel, environmental law has rapidly devel
Background Long-term pathological breathlessness is a life-limiting symptom that risks taking control of the individual’s life. We aimed to evaluate how locus of control (LOC), an individual’s perceived control of present and past life events, relates to breathlessness in a middle-aged general population. Methods A population-based, cross-sectional analysis of people aged 50–64 years was conducted
OBJECTIVE Patients with latent autoimmune diabetes in adults (LADA) express autoantibodies against the 65-kDa isoform of GAD (GADA). Intervention with recombinant human GAD65 formulated with aluminium hydroxide (GAD-alum) given twice subcutaneously to LADA patients at intervals of 4 weeks was safe and did not compromise beta-cell function in a Phase II clinical trial. GADA affinity has been shown
Popular Abstract in Swedish Parkinsons sjukdom är en av våra mest förekommande neurologiska sjukdomar som drabbar den åldrande befolkningen. I åldersgruppen 50-60 år drabbas ca 1 procent av sjukdomen, som karakteriseras av de motoriska symptomen stelhet, långsamma rörelser och skakningar. Symptomen beror på en gradvis förlust av nervceller i en djup del av hjärnan vid namn substantia nigra (den svL-DOPA pharmacotherapy in Parkinson’s disease (PD) is associated with adverse effects occurring after a few years of treatment. Among these, dyskinesia (abnormal involuntary movements) is particularly common and potentially disabling. The causes behind dyskinesia are not completely understood, but intense research has identified a number of neuronal alterations associated with L-DOPA-induced dyski
This dissertation deals with the morphological development in written L2 French by Swedish learners. The thesis presents a detailed analysis of number marking and agreement in NPs and VPs, focusing mainly on the production of the morphemes –s (in NP) and the third person plural –nt (in VP). These agreements are particularly interesting in French where number morphology is often silent in the oral
Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. Its aetiology may involve dietary antioxidant micronutrients such as carotenoids and tocopherols. The objective of this study was to determine the association of plasma levels of seven common carotenoids, their total plasma concentration, retinol and alpha- and gamma-tocopherol, with the risk of gastric ade
In an attempt to identify novel susceptibility genes predisposing to early-onset diabetes (EOD), we performed a genome-wide scan using 433 markers in 222 individuals (119 with diabetes) from 29 Scandinavian families with ≥2 members with onset of diabetes ≤45 years. The highest nonparametric linkage (NPL) score, 2.7 (P < 0.01), was observed on chromosome 1p (D1S473/D1S438). Six other regions on chr
Breeding Ospreys were studied in southern Sweden and 13 birds were tracked by satellite telemetry on autumn migration to the African wintering grounds. This was supplemented with studies of migrating birds at Falsterbo and radar trackings From southern Sweden. Females generally left the nest site 2-3 weeks ahead of males and juveniles. Among males, failed bleeders migrated significantly earlier th
Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32 lipid-associated single-nucleotide polym
Background Although childbearing is known to protect against breast cancer, whether or not breastfeeding contributes to this protective effect is unclear. Methods Individual data from 47 epidemiological studies in 30 countries that included information on breastfeeding patterns and other aspects of childbearing were collected, checked, and analysed centrally, for 50 302 women with invasive breas
BACKGROUND/PURPOSE: There is a lack of large contemporary studies on the management of congenital diaphragmatic hernia (CDH), and the prediction of mortality remains difficult. The aim of this study was to investigate the influence of perinatal factors on mortality rate in a contemporary multicenter study. METHODS: The authors conducted a retrospective multicenter cohort study. Twelve of 13 Scandi
Energi och klimatpåverkan är ständigt aktuellt i dagens samhälle. För att motverka den globala uppvärmningen har EU tagit fram klimatmål där bland annat energianvändningen ska minska med 20 % mot 1990 års nivåer år 2020. En stor andel av energianvändningen orsakas i Sverige idag av bygg- och fastighetsbranschen där byggnadsbeståndet står för ca 30 % av energianvändningen. För att klara EU:s klimEnergy use and climate impact are important topics in today’s society. To combat global warming, the EU has set a goal framework with a 20 % reduction target until 2020 for domestic energy use compared to 1990. Today, the building sector in Sweden accounts for 30 % of the domestic energy use. To achieve the goals for energy and climate set by the EU, changes are required. The Swedish parliament ha
I en bransch som i allt större utsträckning präglas av hållbarhet och miljö, blir det allt viktigare att hitta sätt att återvinna och återanvända snarare än att nyproducera. Ett exempel på detta är när det kommer till de obundna lagren, bär- och förstärkningslager i vägöverbyggnaden. Till dessa används traditionellt bergkross och naturgrus, som bryts från bergtäkter. Dessa material är inte oändligIn an industry that is increasingly affected by sustainability and environmental matters, it is becoming more and more important to find ways to recycle and reuse materials rather than producing new materials. An example of this is when it comes to unbound pavement materials, such as the base and subbase layers. For these layers, mineral aggregate and natural gravel is traditionally used, which ar
The decision of when to exchange habitats represents a significant moment for organisms that utilize migration as a strategy to access growth and feeding opportunities surpassing those available in their natal habitat. For juvenile anadromous salmonids, the initial transition from freshwater to the marine environment marks a critical point in the life cycle characterized by high mortality with mig
High Tech security solutions refer to advanced and innovative technologies designed to protect assets, data and individuals from various threats. These systems offer benefits that traditional security measures cannot match. Examples of high Technology security solutions include Biometric Access Control that uses fingerprints, iris and facial recognition, Surveillance drones with cameras for monito
