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Background Although childbearing is known to protect against breast cancer, whether or not breastfeeding contributes to this protective effect is unclear. Methods Individual data from 47 epidemiological studies in 30 countries that included information on breastfeeding patterns and other aspects of childbearing were collected, checked, and analysed centrally, for 50 302 women with invasive breas
In this thesis a simulation model is presented that enables a comparison of different hybrid topologies, with respect to fuel consumption, emissions and performance. The obtained results stress the properties of the different topologies and form a foundation for the choice of hybrid topology. The simulation models included in this thesis are the result of collaboration with Petter Strandh at the D
Background & Aims: Human milk is believed to contain biological factors involved in the regulation of newborn growth, including brain development. Recently, it has also been shown to contain the calcium-binding S100B protein, regarded as a neurotrophic factor. The present study investigates the concentrations of this protein in colostrum, human milk at different levels of maturation and in mil
Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32 lipid-associated single-nucleotide polym
Despite a variety of testing approaches, it is often difficult to make an accurate diagnosis of Alzheimer's disease (AD), especially at an early stage of the disease. Diagnosis is based on clinical criteria as well as exclusion of other causes of dementia but a definitive diagnosis can only be made at autopsy. We have investigated the diagnostic value of a 96-gene expression array for detection of
Recent research does not show an association between fruit and vegetable consumption and bladder cancer risk. None of these studies investigated variety in fruit and vegetable consumption, which may capture different aspects of consumption. We investigated whether a varied consumption of vegetables and fruits is associated with bladder cancer risk in the European Prospective Investigation into Can
X-ray diffraction methods have been used to study the crystal structure of different compounds, both organic and inorganic. The inorganic compounds were all synthesized by solid state reactions. A new compound, Re4As6S3, was synthesized and its structure was solved by Rietveld methods. Re4As6S3 is a cluster compound described by a
Objective: To report the outcome after ruptured abdominal aortic aneurysm (rAAA) repair in octo- and nonagenarians from the Swedish Vascular Registry 1994-2014. Material and methods: 2335 intact AAA (iAAA) and 1538 rAAA were identified in patients aged 80 years and older. Crude, long-term, and relative survival data were analysed using the Kaplan-Meier method. Crude survival was calculated includi
Flexible Polyvinyl chloride (PVC) is a plastic material commonly used in today’s society and a fundamental material for a lot of sectors. It has advantages over other polymers such as energy-efficient production, flame retardancy, durability and cost-effective. The one important component in flexible PVC that gives it is flexible properties is the plasticizer. The most common plasticizers used are
Popular Abstract in Swedish Parkinsons sjukdom är en av våra mest förekommande neurologiska sjukdomar som drabbar den åldrande befolkningen. I åldersgruppen 50-60 år drabbas ca 1 procent av sjukdomen, som karakteriseras av de motoriska symptomen stelhet, långsamma rörelser och skakningar. Symptomen beror på en gradvis förlust av nervceller i en djup del av hjärnan vid namn substantia nigra (den svL-DOPA pharmacotherapy in Parkinson’s disease (PD) is associated with adverse effects occurring after a few years of treatment. Among these, dyskinesia (abnormal involuntary movements) is particularly common and potentially disabling. The causes behind dyskinesia are not completely understood, but intense research has identified a number of neuronal alterations associated with L-DOPA-induced dyski
Med sin ökade tillgänglighet på den kommersiella marknaden har eye-tracking blivit ett allmänt tillgängligt system för att analysera ögonrörelser. Detta har öppnat upp för nya möjligheter för utvärdering av usability inom humancomputer interaction, som tidigare har varit dyrt, tidskrävande och ofta utfört baserat på dåligt dokumenterade standarder och mål. Tidigare forskning har visat att eye-tracWith its increased availability on the commercial market, eye-tracking has become a widely accessible system for analysing eye-movements. This has opened up new possibilities in evaluation of usability in human-computer interaction, which has had a history of being expensive, time-consuming and often performed based on poorly documented standards and objectives. Previous research has indicated the
Since its inception, Estonia has been at the forefront of innovation in terms of e-governance and applications of online systems into various aspects of Estonians’ lives. In 2014 Estonia opened up it’s digital borders and launched a digital economic citizenship - e-Residency - available to anyone in the world for using Estonian e-services to register and manage a company online. In May 2018, 5000
I det här arbetet har två parallella marina sedimentkärnar från Inre Egedesminde Dyb i Diskobukten, västra Grönland, undersökts. Diskobukten är den nordligaste delen längs den Grönländska västkusten var det förhållandevis varma vattnet från Atlanten transporteras med den västra Grönlandströmmen. Båda kärnorna scannades med hjälp av fluorescencespectrometry (XRF) för att erhålla den elementära sammTwo parallel sediment cores were retrieved from the Inner Egedesminde Dyb marine trench at Disko Bugt, West Greenland. Disko Bugt is the most northern point along the Western Greenland coast where relatively warm Atlantic water penetrates through the West Greenland Current. Both cores were subjected to Xray fluorescence spectrometry (XRF) scanning to obtain the elemental composition of the sedimen
Cellular signalling and potential agents to combat prostate cancer Prostate cancer (PCa) arises as a result of uncontrolled proliferation of the cells in the male prostate gland. The male androgenic hormone, testosterone fuels prostate cancer cells. In the cells of the prostate, the androgen receptor (AR) acts as the signal receiver and effector of androgen, ultimately leading to the growth and s
Glulam is almost exclusively the chosen material of timber frame structures. Of those, three-hinged (three-pin) portal frames are incomparably the most common type. Being both statically determinate and stable against horizontal forces in its own plane offer both practical (basic constructive details) and economical benefits. The design of the haunch allows for various solutions: it can be curved
Exposure to Ljungan virus (LV) is implicated in the risk of autoimmune (type 1) diabetes but possible contribution by other parechoviruses is not ruled out. The aim was to compare children diagnosed with type 1 diabetes in 2005-2011 (n = 69) with healthy controls (n = 294), all from the Jämtland County in Sweden, using an exploratory suspension multiplex immunoassay for IgM and IgG against 26 pept
BACKGROUND/PURPOSE: There is a lack of large contemporary studies on the management of congenital diaphragmatic hernia (CDH), and the prediction of mortality remains difficult. The aim of this study was to investigate the influence of perinatal factors on mortality rate in a contemporary multicenter study. METHODS: The authors conducted a retrospective multicenter cohort study. Twelve of 13 Scandi
I en bransch som i allt större utsträckning präglas av hållbarhet och miljö, blir det allt viktigare att hitta sätt att återvinna och återanvända snarare än att nyproducera. Ett exempel på detta är när det kommer till de obundna lagren, bär- och förstärkningslager i vägöverbyggnaden. Till dessa används traditionellt bergkross och naturgrus, som bryts från bergtäkter. Dessa material är inte oändligIn an industry that is increasingly affected by sustainability and environmental matters, it is becoming more and more important to find ways to recycle and reuse materials rather than producing new materials. An example of this is when it comes to unbound pavement materials, such as the base and subbase layers. For these layers, mineral aggregate and natural gravel is traditionally used, which ar
Energi och klimatpåverkan är ständigt aktuellt i dagens samhälle. För att motverka den globala uppvärmningen har EU tagit fram klimatmål där bland annat energianvändningen ska minska med 20 % mot 1990 års nivåer år 2020. En stor andel av energianvändningen orsakas i Sverige idag av bygg- och fastighetsbranschen där byggnadsbeståndet står för ca 30 % av energianvändningen. För att klara EU:s klimEnergy use and climate impact are important topics in today’s society. To combat global warming, the EU has set a goal framework with a 20 % reduction target until 2020 for domestic energy use compared to 1990. Today, the building sector in Sweden accounts for 30 % of the domestic energy use. To achieve the goals for energy and climate set by the EU, changes are required. The Swedish parliament ha
PURPOSE:: To describe riboflavin and ultraviolet light (UV) collagen crosslinking as an effective treatment for infectious keratitis. METHODS:: A 25-year-old previously healthy female contact lens user was diagnosed with unilateral severe keratitis with unclear pathogenesis, although the clinical presentation suggested acanthamoeba as the infectious agent. A 4-mm diameter, annular, semi-opaque inf
